1,721,158 research outputs found
[Heart-gut interactions]
No full textThe known interactions between the heart and the digestive system, concerning the semeiotic and the pathophysiology of coronary and non-coronary pain and the possible causal relationship between reflux pathology and the onset of atrial fibrillation, have been implemented by the most recent acquisitions on the role of intestinal microbiota in the development of atherosclerosis, hypertension and heart failure; this brief review also addresses these more innovative aspects
Trattamento anti-ipertensivo in rapporto al genere ed all'età.
No full textSpecificità relative al trattamento dell'ipertensione in funzione dell'età o del sesso, con particolare riferimento a condizioni particolari delle pazienti di sesso femminile o della possibilità di effetti indesiderati diversi fra i due sessi come quelli che interessano la sfera sessuale
β-Blocking Properties of Propafenone in Extensive Oxidisers: A Study on Heart Rate Behaviour during Holter Monitoring
No full textThe aims of this study were to evaluate whether the beta-blocking effect during propafenone treatment is clinically significant even in extensive metabolisers of debrisoquine (> 90% of Caucasians), and to identify the kinetic determinants of such an effect. 11 patients, classified as extensive oxidisers of debrisoquine, with stable ventricular contractions (> 100/hour) were studied by Holter monitoring in basal condition and after 14 days of treatment with propafenone 300mg 3 times daily. A complete pharmacokinetic assessment, with serial plasma samples for propafenone and 5-hydroxy propafenone determination, was performed during washout. A mean reduction in either maximum heart rate (HR max) [-7.1%] or mean heart rate (HR mean) [-4.2%] was observed during treatment with propafenone, but its extent varied within the patient population from 0 to 17%. The degree of HR slowing was related to the area under the concentration-time curve of propafenone (r = 0.725, p < 0.02 for HR max; r = 0.715, p < 0.02 for HR mean) as well as to propafenone minimum concentrations at steady-state (r = 0.809, p < 0.005 for HR max; r = 0.752, p < 0.01 for HR mean) without significant relationships to 5-hydroxy propafenone levels or to age. HR max percentage reduction during therapy was significant compared with basal values only during daytime hours (-8.1%, p < 0.005), suggesting a beta-blocking effect, and was again related to the area under the concentration-time curve of propafenone (r = 0.704, p < 0.02) and to propafenone minimum steady-state concentrations (r = 0.786, p < 0.005). A strict relationship between oxidative metabolism, evaluated by debrisoquine hydroxylation and propafenone metabolism, was observed (r = 0.982, p < 0.001). In conclusion, a beta-blocking effect during treatment with propafenone 300mg 3 times daily can be detected even by Holter monitoring performed during daily activity. However, the extent of such an effect varies widely between individuals, depending on propafenone plasma levels. The degree of oxidative metabolism is thus a major determinant of the clinical beta-blocking effect of propafenone
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Metabolic alterations and hearing acuity: lack of a significant clinical correlation
No full textObjective: To contribute to assessing the extent of the clinical significance of metabolic alterations in terms of hearing deterioration. Study design: The design enabled comparison of the serum level of cholesterol, apolipoproteins, glucose and uric acid in a homogeneous, controlled population of subjects with normal hearing and with symmetrical sensorineural hearing loss, respectively. All subjects were enrolled within the Brisighella Heart Study (BHS), a prospective, population based longitudinal epidemiological investigation involving almost 3000 randomly selected Caucasian subjects living in Brisighella, a small town in northern Italy. Results: No statistical difference was identified in the metabolic assessment of the two groups (normal hearing vs. impaired hearing). In particular, alteration of the serum lipids, glucose and uric acid parameters is not significantly associated with hearing loss (p > 0.01). Conclusions: The findings, apparently in disagreement with common opinion, seem to imply that the role of metabolic disorders is not pre-eminent in the genesis of non-acute hearing loss. It is possible to hypothesize that all mechanisms regulating the microcirculation of the inner ear can constitute a ‘buffer’ against the related cellular damage. It is likely that if a convenient and sufficiently stable degree of oxygenation is maintained, this might be enough to preserve hearing function even under unfavourable metabolic conditions
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