322,968 research outputs found
Aproximación al estudio de la lengua poética de Tommaso Stigliani
No full textIn this study, we have attempted to make inroads into the study of the poetic language of the Italian author, Tommaso Stigliani, analysing his principal work, Il Mondo Nuovo (1628), an epic poem on the discovery of America. We have examined the main phenomena of orthography, phonetics, morphology, syntax and lexicon that appear in the text, taking into account the linguistic norms of the 17th century, as well as the opinions and theories of the major linguistic experts of that period. Our study, therefore, gives an insight into Tommaso Stigliani¿s conception of poetic language, which, through his poem and his theoretical writings, he maintained for the duration of his literary careerEn este estudio hemos querido trazar un primer acercamiento al estudio de la lengua poética del autor italiano Tommaso Stigliani y lo hemos hecho analizando su mayor obra, Il Mondo Nuovo (1628), poema épico sobre el descubrimiento de América. Hemos analizado los principales fenómenos de la ortografía, la fonética, la morfología, la sintaxis y el léxico que aparecen en el texto, teniendo en cuenta la norma lingüística del siglo XVII y las opiniones y teorías de los principales lingüistas de la época. Con este estudio, por tanto, ofrecemos un acercamiento a la concepción de lengua poética que Tommaso Stigliani, a través de su poema y de sus escritos teóricos, puso de manifiesto a lo largo de su carrera literaria
Successful design management in small and medium businesses
No full textReports from research on conditions that facilitate or hamper collaboration between design and busines
Transformations by Design Thinking: Exploring the Value of Design Thinking in Consulting Projects
No full textThe sensisivity of catecholamine release to botulinum toxin C 1 and E suggests selective targeting of vesicles set into the readily releasable pool
No full textThe impact of syntaxin and SNAP‐25 cleavage on [3H]noradrenaline ([3H]NA) and [3H]dopamine ([3H]DA) exocytotic release evoked by different stimuli was studied in superfused rat synaptosomes. The external Ca2+‐dependent K+‐induced [3H]catecholamine overflows were almost totally abolished by botulinum toxin C1 (BoNT/C1), which hydrolyses syntaxin and SNAP‐25, or by botulinum toxin E (BoNT/E), selective for SNAP‐25. BoNT/C1 cleaved 25% of total syntaxin and 40% of SNAP‐25; BoNT/E cleaved 40% of SNAP‐25 but left syntaxin intact. The GABA uptake‐induced releases of [3H]NA and [3H]DA were differentially affected: both toxins blocked the former, dependent on external Ca2+, but not the latter, internal Ca2+‐dependent. BoNT/C1 or BoNT/E only slightly reduced the ionomycin‐evoked [3H]catecholamine release. More precisely, [3H]NA exocytosis induced by ionomycin was sensitive to toxins in the early phase of release but not later. The Ca2+‐independent [3H]NA exocytosis evoked by hypertonic sucrose, thought to release from the readily releasable pool (RRP) of vesicles, was significantly reduced by BoNT/C1. Pre‐treating synaptosomes with phorbol‐12‐myristate‐13‐acetate, to increase the RRP, enhanced the sensitivity to BoNT/C1 of [3H]NA release elicited by sucrose or ionomycin. Accordingly, cleavage of syntaxin was augmented by the phorbol‐ester. To conclude, our results suggest that clostridial toxins selectively target exocytosis involving vesicles set into the RRP
Multiple mechanisms of transmitter release evoked by 'pathologically' elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calcium
No full textRe: Safety and efficacy concerns of long-acting GnRH agonist trigger for ovulation induction in oncological patients undergoing oocyte cryopreservation: a call for caution and further investigation
No full textMitochondrial DNA content in embryo culture medium is significantly associated with human embryo fragmentation
No full textHow Should we Perform a Preoperative Multidimensional Assessment of Elderly Patients with Advanced Ovarian Cancer?
No full textBorderline ovarian tumours: Management in the era of fertility-sparing surgery
No full textBorderline ovarian tumours (BOTs) are ovarian neoplasms characterised by epithelial proliferation, variable nuclear atypia and no evidence of destructive stromal invasion. BOTs account for approximately 15% of all epithelial ovarian cancers. Due to the fact that the majority of BOTs occur in women under 40 years of age, their surgical management often has to consider fertility-sparing approaches. The aim of this mini-review is to discuss the state of the art of fertility-sparing surgery for BOTs with a specific focus on the extent of surgery, post-operative management and fertility
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