1,720,975 research outputs found
ELEVATED RISK OF THROMBOTIC MANIFESTATIONS OF SARS-COV-2 INFECTION IN CANCER PATIENTS: A LITERATURE REVIEW
No full textCoronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena
Un modello di malattia da poliglutammine: clinica e diagnosi della Corea di Huntington
No full textLa corea di Huntington (Corea major) è una grave patologia degenerativa su base genetica del Sistema Nervoso, descritta nel 1872 da George Huntington, che porta inevitabilmente alla perdita delle funzioni motorie, a ritardo mentale e a morte precoce. Tale malattia insorge in età adulta, generalmente intorno ai 35 anni. Sono stati tuttavia descritti casi ad insorgenza precoce, intorno ai 15-16 anni. Solo all’inizio del XX secolo si riconobbe l’esistenza di un processo atrofico-degenerativo interessante il neo-striato e la corteccia cerebrale, quale responsabile del quadro sintomatologico. Di seguito descriviamo sia alcuni aspetti clinici che molecolari di questa malattia, quale modello di malattia neurodegenerativa su base genetica
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Pathophysiological Roles of Transglutaminase - Catalyzed Reactions in the Pathogenesis of Human Diseases
No full text""Transglutaminases (TGs, E.C. 2.3.2.13) are related and ubiquitous enzymes which catalyze the cross linking of. a glutaminyl residue of a protein\\\/peptide substrate to a lysyl residue of a protein\\\/peptide co-substrate. These enzymes are. also capable of catalyzing other reactions which are important for cell life. To date, at least eight different human TGs. have been identified. The distribution and the physiological roles of human TGs have been widely studied in numerous. cell types and tissues and recently their roles in several diseases have begun to be identified. It has been hypothesized that. transglutaminase activity is directly involved in the patho-genetic mechanisms responsible for several human diseases. In. particular, TG2, a member of the TG enzyme family, has been shown to be involved in the molecular mechanisms. responsible for a very widespread human pathology, Celiac Disease (CD), one of the most common food intolerances. described in the western population. The main food agent that provokes the strong and diffuse clinical symptoms has been. known for several years to be gliadin, a protein present in a very large number of human foods derived from vegetables.. The aim of this review is to summarize the most recent findings concerning the relationships between the biochemical. properties of the transglutaminase activity and the basic molecular mechanisms responsible for CD. In addition, we. present some clinical associations of CD with other human diseases, with particular reference to neuropsychiatric. disorders. Possible molecular links between biochemical activities of transglutaminase enzymes, CD and neuropsychiatric disorders are discussed."
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