166,190 research outputs found
Dynamics of mononuclear phagocytes in sarcoidosis and other granulomatous disorders
No full textOort, J. [Promotor]Stam, J. [Copromotor
J. Stam-Dresselhuys ex librise
No full texthttp://www.lib.unideb.huDebreceni Egyetem Egyetemi és Nemzeti KönyvtárElhúzott függönyű ablak előtt csukott könyv és virágcsokros váza asztalon. Az ablakban a csillagos-újholdas éjszakai ég látszik. Jobbra és lent felirat: Ex libris J. Stam Dresselhuys. A szerző/tulajdonos neve az ex libris hátlapjára felvezetve.metsze
J. Stam. Prudentius Hamartigenia. With Introduction, Translation and Commentary
No full textHélin M. J. Stam. Prudentius Hamartigenia. With Introduction, Translation and Commentary. In: L'antiquité classique, Tome 11, fasc. 1, 1942. pp. 128-129
J. Stam. Prudentius Hamartigenia. With Introduction, Translation and Commentary
No full textHélin M. J. Stam. Prudentius Hamartigenia. With Introduction, Translation and Commentary. In: L'antiquité classique, Tome 11, fasc. 1, 1942. pp. 128-129
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Functional mapping of the sensorimotor cortex: Clinical studies with MEG and fMRI
No full textVandertop, W.P. [Promotor]Stam, C.J. [Promotor
Central Station and issues of identity in film form and critical debates
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2009O presente trabalho trata de questões relacionadas à construção de uma identidade cultural brasileira no filme Central do Brasil, dirigido por Walter Salles, a partir da perspectiva fílmica e também relacionada aos debates críticos que o filme gerou em resenhas americanas e brasileiras. Argumenta-se que o filme é uma metáfora da busca por identidade, argumento usado pelo próprio diretor. Esta busca se dá no nível pessoal, no caso das personagens principais, Dora e Josué, e nacional, já que o filme encoraja a associação da jornada das personagens a uma busca pela identidade nacional brasileira. A pesquisa buscou encontrar os elementos fílmicos que remetem a essa hipótese de que o filme é uma metáfora da busca por identidade, bem como de que forma (e se) os debates críticos gerados a partir do filme identificaram essa questão da busca. Para teorias de identidade, autores como Stuart Hall, Zygmunt Bauman e Robert Stam foram usados. Para teoria fílmica foram usados trabalhos de David Bordwell e Marcel Martin. Para estudos em cinema brasileiro, leituras de trabalhos de Luiz Zanin Oricchio, Robert Stam e Sidney Ferreira Leite foram realizadas. A análise mostrou que o filme, de fato, traz elementos que podem ser relacionados à metáfora da busca por identidade.This research addresses questions related to the construction of a Brazilian cultural identity in the film Central Station, directed by Walter Salles, from the perspective of film form, and concerning the critical debates prompted by the film in Brazilian and American reviews. The film is argued to be, by the director himself, a metaphor for the search for identity, both personal, in the case on the main characters, Dora and Josué, and national, since the film encourages the association of the characters' journey to a search for a Brazilian identity. What this research sought to find were the elements in film form that relate to this hypothesis of the film as a metaphor for the search of identity, and how and if the critical debates prompted by the film identified the issue of identity. For the issue of identity, critics such as Stuart Hall, Robert Stam, and Zygmunt Bauman were invoked. For Film Studies, theorists such as Bordwell and Marcel Martin were used. For readings in Brazilian Cinema, the works of Luiz Zanin Oricchio, Robert Stam and Sidney Ferreira Leite were used. The analysis showed that the film, indeed, brings elements that can be related to a metaphor for the search for identity
The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation
No full textIn chapter 2 a number of the mechanisms are discussed through which genetic polymorphisms can be maintained in natural populations: overdominance, frequency dependent selection and neutral alleles with associative overdominance. The overdominance model is emphasized because overdominance is also the basic feature of the associative overdominance model. Different theoretical relationships between number of heterozygous loci and fitness are explored, including their implications with regard to mean population fitness and selection coefficients at individual loci in an ideal population. From these, King's threshold model for multiple gene action on fitness proved to be the most satisfactory in all respects: it accomodates fairly high selection coefficients at individual loci without implying too heavy a load; it further explains different inbreeding depressions for different organisms and for different environments, as well as genotype by environment interaction. The model of associative overdominance, with the incorporation of King's threshold model for multiple gene action, has been chosen as an operational hypothesis for explanation of my experimental results (chapter 3) and as a basis for the simulation study (chapter 4).Chapter 2 further discusses the implications of associative overdominance (which is a result of overall linkage disequilibrium in finite populations) when linkage disequilibrium is generated artificially by using a small sample to found a new population. In this situation pseudo-frequency dependent selection is expected to occur at selectively neutral loci. An experimental design is proposed which distinguishes between apparent and real frequency dependent selection.Chapter 3 presents the experiments: individuals from two laboratory stocks of Tribolium castaneum HERBST, together with their F 1 , were used to initiate a set of polymorphic populations (for the black locus) with different frequencies of the marker allele. These experiments, jointly taken, indicate that the black locus itself is selectively neutral under the current experimental conditions and rule out the possibility of real frequency dependent selection. There was however apparent selection against the mutant allele due to initial linkage disequilibrium. This linkage disequilibrium is described in terms of the different genotypic backgrounds of the components (wild type and mutant stock and F 1 ) of the founder population: in the mutant stock there is an excess of homozygosity which may be randomly distributed over the chromosomes or may be partially or wholly concentrated in a chromosome region near the marker locus. This confirms the expectation formulated in the Introduction (chapter 1). The initial linkage disequilibrium, in these experiments is not so much due to small samples from the founder stocks as to the different genotypic backgrounds of the founder stocks, and, with respect to neutral loci, implies associative dominance rather than associative overdominance. The apparent decrease in selection against the b allele is a result of the approach to linkage equilibrium.A comparison of the fitness differences among the original marker genotypes (wild type, mutant black and F 1 ) on the one hand and the marker genotypes of an F 2 population on the other band, showed that the fitness loci closely linked to the marker locus and the joint non-linked fitness loci made approximately equal contributions to the fitness contrast between the two founder stocks (i.c. a lower fitness of the mutant stock). It also showed that, under the current experimental conditions, differential viability only played a minor role, if any, in the gene frequency changes of the b allele in the pooled populations.Chapter 4 presents a computer model for (stochastic) simulation of the population experiments. This model is based on the hypothesis of overdominance at the chromosomal level and on the assumption that only the marker chromosome contributes to the fitness difference between the founder stocks. For this purpose FRASER'S technique of binary representation of genotypes was adopted.After correction for some discrepancies between the simulation model and the experiments (in the simulation only the marker chromosome is considered and selection acts through differential viability), the results of simulation proved to be in fairly good agreement with the experimentally obtained results. The simulation model can readily be adapted to other situations, e.g. both founder stocks being 'inbred', tracking the gene frequencies at more than one neutral locus, and any arbitrary function relating the number of heterozygous loci to fitness.The final conclusion from both the experiments and the simulation study is, that after introducing the relatively 'inbred' mutant stock into the wild type population, a great deal of the genetic material of the mutant stock is lost by natural selection. For practical breeding this implies a risk of losing part of the genetic material, as a result of natural selection, from small samples of (relatively) inbred populations which are introduced into a breeding stock. Of course, the breeder may artificially select in favour of a fitness-neutral character introduced by the 'fresh' genetic material; however, the effect of artificial selection may be greatly reduced when (in the initial generations) natural selection outweighs artificial selection, since natural selection 'acts' against the desired character through linkage disequilibrium with fitness loci
<i>hrs</i> and <i>stam</i> mutants display enlarged early endosomes in <i>Drosophila</i>.
No full text<p>A–D. Close-up pictures of <i>wild type</i>, <i>stam</i>, <i>hrs</i> and <i>hrs, stam</i> mutant cells induced with the MARCM system in the dorsal ASP. Scale bar: 15 µm. Mutant clones are visualised by the expression of Rab5-GFP to detect early endosomes. Note the large size of early endosomes in <i>stam</i> (B), <i>hrs</i> (C) and <i>hrs, stam</i> (D) mutant cells compared to <i>FRT40A</i> cells used as a wild type control (A). The tracheal cells were labeled with RFP-moesin (red). Arrows indicate early endosomes stained with GFP. Pictures shown are single scan sections. E–H. MARCM clones mutant for <i>hr</i>s, <i>stam</i> and <i>hrs, stam</i> in the wing imaginal disc of third instar larvae. Scale bar: 15 µm. Mutant cells express the Rab5-GFP fusion protein. As in the ASP, early endosomes are enlarged in <i>stam</i> (F), <i>hrs</i> (G) and <i>hrs, stam</i> (H) mutant cells compared to <i>FRT40A</i> cells used as a control (E). The cells were detected with phalloidin to follow F-actin and the shape of the cells. Arrows indicate early endosomes stained with GFP. Pictures shown are single scan sections. I–L. HRP uptake experiment in Garland cells of <i>wild-type</i>, <i>stam, hrs</i> and <i>hrs, stam</i> larvae. I. In wild-type Garland cells, many small endosomes are observed (highlighted in light red). Scale bar equals 460 nm. Endosomes from <i>stam</i> and <i>hr</i>s mutant larvae are dramatically enlarged (J–L), especially in <i>stam</i> mutants (J), compared to <i>FRT40A</i> larvae (I).</p
- …
