16,703 research outputs found
Hormonal regulation of human adipocytes at the cross-roads between obesity and hypertension
status: Publishe
Tight BP control reduced left ventricular hypertrophy in nondiabetic patients with hypertension
Compared with whom? Addressing the prognostic value of ambulatory blood pressure categories
status: Publishe
Should high-normal blood pressure be treated?
Letter about the importance of high-normal BP in determining cardiovascular risk
Blood pressure and hypertension in relation to lead exposure updated according to present-day blood lead levels
Lead is an environmental hazard that should be addressed worldwide. Over time, human exposure to lead in the Western world has fallen drastically to the levels comparable to those in humans living in the pre-industrial era, who were mainly exposed to natural sources of lead. To re-evaluate the health risks possibly associated with present-day lead exposure, a three-pronged approach was applied. First, we critically assessed the recently published population metrics describing the adverse health effects associated with lead exposure at the population level. Next, we summarized the key results of the Study for Promotion of Health in Recycling Lead (SPHERL; NCT02243904) and analyzed these results in the context of the published population metrics. Last but not least, we performed a brief literature review on the present-day lead exposure level in Poland. To our best knowledge, SPHERL is the first prospective study that accounted for interindividual variation in vulnerability to the toxic effects of lead exposure by assessing the participants' health status before and after occupational lead exposure, with blood pressure and hypertension as the primary outcomes. The overall conclusion of this comprehensive review on blood pressure and hypertension is that mainstream ideas about the public and occupational health risks related to lead exposure need to be urgently updated because a large part of the available literature has become obsolete given present-day exposure levels that sharply declined over the past 40 years.Funding:
The International Lead Association (www.ila-lead.org) provided an unrestricted grant to the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, partially supporting data collection and management and statistical analysis of the SPHERL project. The Non-Profit Research Association Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium (URL, www.appremed.org) received a nonbinding grant from OMRON Healthcare Co Ltd, Kyoto, Japan. These funders played no role in the decision to submit this review article
Cardiovascular effects of tight versus usual blood-pressure control. Authors' reply
status: Publishe
Community based trial of home blood pressure monitoring with nurse-led telephone support in patients with stroke or transient ischaemic attack recently discharged from hospital.
BACKGROUND: High blood pressure in patients with stroke increases the risk of recurrence but management in the community is often inadequate. Home blood pressure monitoring may increase patients' involvement in their care, increase compliance, and reduce the need for patients to attend their General Practitioner if blood pressure is adequately controlled. However the value of home monitoring to improve blood pressure control is unclear. In particular its use has not been evaluated in stroke patients in whom neurological and cognitive ability may present unique challenges.
DESIGN: Community based randomised trial with follow up after 12 months.
PARTICIPANTS: 360 patients admitted to three South London Stroke units with stroke or transient ischaemic attack within the past 9 months will be recruited from the wards or outpatients and randomly allocated into two groups. All patients will be visited by the specialist nurse at home at baseline when she will measure their blood pressure and administer a questionnaire. These procedures will be repeated at 12 months follow up by another researcher blind as to whether the patient is in intervention or control group.
INTERVENTION: INTERVENTION patients will be given a validated home blood pressure monitor and support from the specialist nurse. Control patients will continue with usual care (blood pressure monitoring by their practice). Main outcome measures in both groups after 12 months: 1. Change in systolic blood pressure.2.
Cost effectiveness: Incremental cost of the intervention to the National Health Service and incremental cost per quality adjusted life year gained
Kasvatus, toimijuus ja voimaantuminen : kasvatusantropologinen tutkimus andalusialaisten naisten arjesta
Tiedostavaan lähestymistapaan ja kasvatusantropologiseen tutkimusotteeseen tukeutumalla voidaan rakentaa kulttuurisensitiivistä tietoa, joka avaa tutkittavan ilmiön merkityskenttiä sen toimijoiden näkökulmasta. Tutkimuksessa tarkastellaan, miten kasvatusantropologista utkimusotetta voidaan hyödyntää kasvatuksen ja koulutuksen tutkimuksessa huomioimalla sen vaihtuvat tarkastelukulmat ja epistemologiselta taustaltaan erilaiset käsitykset tutkittavasta ilmiöstä.
Tutkimus paikantuu Etelä-Espanjaan, andalusialaiseen urbaaniin kylään. Tutkimusaineisto tuotettiin kolme vuotta kestäneen etnografisen kenttätyön aikana. Tutkimusprosessi tukeutui refleksiiviseen ja dialogiseen tiedon tuottamisen tapaan sekä menetelmä-,aineisto- ja teoriatriangulaatioon. Tutkimusaineisto analysoitiin hyödyntäen etnografista lukutapaa sekä sisällön erittelyn ja temaattisen koodauksen keinoja. Tekstissä rakennetaan vuoropuhelua kulttuurin sisäisen ja teoreettisen viitekehyksen välille. Tutkimus koostuu avainkäsitteiden erittelystä sekä etnografisesta kontekstin, ilmiön ja tutkimusprosessin kuvauksesta.
Kontekstin aikuisikäisten naisten toimijuudet näyttäytyivät moninaisina ja jatkuvan neuvottelun kohteina. Kontekstissa vaikuttivat rinnakkain vahvat, historialliskulttuuriset naisten toimijuutta määrittävät perinteet sekä yhteiskunnalliset muutokset ja yksilölähtöiset muutostarpeet. Näistä edeltävät tukivat tapaistunutta, kodin ja perheen ympärille kietoutunutta toimijuutta. Kontekstissa vallalla olleet reunaehdot loivat kokemusta rajoittuneesta toimijuudesta. Muutokset ja muutostarpeet puolestaan tukivat neuvotteluja ammatillisesta ja aktiivisesta toimijuudesta.
Yhteisöllisellä tasolla muutostarpeisiin oli vastattu erilaisilla, aikuisille naisille suunnatuilla non-formaaleilla ja formaaleilla kasvatus- ja koulutustapahtumilla. Tekstissä lähestytään toteutettuja koulutuksellisia kokonaisuuksia voimaantumisen näkökulmasta. Kontekstin tarpeet ja haasteet huomioivat koulutukselliset tapahtumat edistivät naisten kriittistä ja tiedostavaa oman paikan, tarpeiden, mahdollisuuksien ja rajojen hahmottamista. Ne antoivat välineitä ja tukea vaikuttamiseen sekä muutoksen toteuttamiseen.
Tutkimusprosessin osallistuva, osallistava ja tiedostava tutkimusote aktivoi tutkimukseen osallistuneita naisia. Omista kokemuksista ja näkemyksistä puhuminen vahvisti tunnetta oman elämän merkityksellisyydestä.With a conscious, educational-anthropological research approach one can produceculturally sensitive information of the research phenomenon and its various meanings from the viewpoint of subjects in the field. In this study, it is evaluated how the anthropologicalapproach can be utilized in educational research by examining various analytical viewpoints and epistemologically diverse understandings about the research phenomenon.
The research was done in Southern Spain, in an urban Andalusian village. The research data were obtained during three years of ethnographic field work. The research process was based on reflective and dialogic ways of producing knowledge as well as on method, data, and theory triangulations. The data were analyzed by using ethnographic interpretation and thematic coding. The research report includes a dialogue between the culture-specific nd theoretical frameworks. The study consists of an analysis of key concepts, descriptions of the ethnographic context, phenomenon, and research process.
The adult women’s agency within the research context seemed manifold and target of constant negotiations. Strong historical-cultural traditions defining women’s agency appeared side by side with societal changes and individual-based needs for changes. The former supported routine based agency intertwined around home and family. Prevailing conditions provided women with a sense of limited agency. Changes and needs for change supported negotiations about professional and active agency.
At the communal level, needs for change were met with various non-formal and formal educational events aimed at adult women. The educational entities are analyzed from the point of view of empowerment. Events which took contextual needs and challenges into account enhanced women’s ability to conceive their place, needs, and opportunities critically and consciously. These events also provided women with the means and support to influence and realize change.
The participatory, participating, and conscious research approaches activated the research participants. Discussing their own experiences and opinions strengthened women’s sense of the meaningfulness of their lives.ei tietoa saavutettavuudest
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