1,721,134 research outputs found
Per un nuovo patto fra il giornalismo e i suoi pubblici
No full textIl panorama mediatico ha subito negli ultimi anni importanti modificazioni. La comunicazione digitale e la massiccia diffusione dei social network hanno generato una crescente richiesta di interconnessione, rafforzando ulteriormente il carattere individuale dei processi di comunicazione nella società contemporanea
State of the art CRISPR-based strategies for cancer diagnostics and treatment
No full textClustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology is a groundbreaking and dynamic molecular tool for DNA and RNA “surgery”. CRISPR/Cas9 is the most widely applied system in oncology research. It is a major advancement in genome manipulation due to its precision, efficiency, scalability and versatility compared to previous gene editing methods. It has shown great potential not only in the targeting of oncogenes or genes coding for immune checkpoint molecules, and in engineering T cells, but also in targeting epigenomic disturbances, which contribute to cancer development and progression. It has proven useful for detecting genetic mutations, enabling the large-scale screening of genes involved in tumor onset, progression and drug resistance, and in speeding up the development of highly targeted therapies tailored to the genetic and immunological profiles of the patient’s tumor. Furthermore, the recently discovered Cas12 and Cas13 systems have expanded Cas9-based editing applications, providing new opportunities in the diagnosis and treatment of cancer. In addition to traditional cis-cleavage, they exhibit trans-cleavage activity, which enables their use as sensitive and specific diagnostic tools. Diagnostic platforms like DETECTR, which employs the Cas12 enzyme, that cuts single-stranded DNA reporters, and SHERLOCK, which uses Cas12, or Cas13, that specifically target and cleave single-stranded RNA, can be exploited to speed up and advance oncological diagnostics. Overall, CRISPR platform has the great potential to improve molecular diagnostics and the functionality and safety of engineered cellular medicines. Here, we will emphasize the potentially transformative impact of CRISPR technology in the field of oncology compared to traditional treatments, diagnostic and prognostic approaches, and highlight the opportunities and challenges raised by using the newly introduced CRISPR-based systems for cancer diagnosis and therapy
Insegnanti con disabilità o DSA e colleghi: un’analisi delle esperienze dal percorso universitario a quello scolastico
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Embodied cognition e pause attive: un approccio didattico integrato per il curricolo matematico nella scuola primaria
Full text linkIl contributo propone un modello teorico e metodologico per l’integrazione delle pause attive nel curricolo matematico della scuola primaria, all’interno del paradigma dell’Embodied Cognition e della didattica inclusiva. A partire dalla cornice dell’Embodied Mathematics e dai principi dell’Universal Design for Learning, l’articolo illustra la progetta-zione e l’articolazione del programma ABMOVE!, sviluppato nell’ambito del PRIN PNRR 2022 “Inclusive didactic for enhancing math learning and reducing math anxiety: efficacy of active breaks in the classroom”, finanziato dall’Unione europea – Next Generation EU, (Cod. P20223RHM, CUP B53D23029710001). Le pause attive sono concepite come artefatti di-dattici embodied, progettati per promuovere la concettualizzazione matematica mediante l’integrazione intenzionale tra movimento corporeo e strutture matematiche. Particolare at-tenzione è dedicata all’integrazione concettuale, alla dimensione multimodale e alla proget-tazione inclusiva delle attività, supportata da materiali cartacei, video e tecnologie didattiche. Il modello proposto mira a valorizzare il ruolo del corpo come soggetto epistemico nel processo di apprendimento matematico, offrendo una prospettiva innovativa per una didattica più accessibile, motivante e significativa
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Variabilità dell’attitudine rizogena ed effetto di trattamenti di stimolo alla radicazione di talee di cultivar campane di olivo
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
