1,654 research outputs found
The eight human “canonical” ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins
No full textHuman ribonucleases (RNases) are members of a large superfamily of rapidly evolving homologous
proteins. Upon completion of the human genome, eight catalytically active RNases (numbered 1–8)
were identified. These structurally distinct RNases, characterized by their various catalytic differences
on different RNA substrates, constitute a gene family that appears to be the sole vertebratespecific
enzyme family. Apart from digestion of dietary RNA, a wide variety of biological actions,
including neurotoxicity, angiogenesis, immunosuppressivity, and anti-pathogen activity, have been
recently reported for almost all members of the family. Recent evolutionary studies suggest that
RNases started off in vertebrates as host defence or angiogenic proteins.
_ 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved
Enzymatic degradation of double-stranded RNA: Action of dimers and higher aggregates of RNase A in comparison with that of other pancreatic type RNases
No full textEnzymatic degradation of double-stranded RNA: Action of dimers and higher aggregates of RNase A in comparison with that of other pancreatic type RNases
No full text
Revisiting the action of bovine ribonuclease A and pancreatic-type ribonucleases on double-stranded RNA.
No full textRevisiting the action of bovine ribonuclease A and pancreatic-type ribonucleases on double-stranded RNA.
No full text
Human pancreatic-type and nonpancreatic-type ribonucleases: a direct side-by-side comparison of their catalytic properties.
No full textHuman pancreatic-type and nonpancreatic-type ribonucleases: a direct side-by-side comparison of their catalytic properties.
No full textAn interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer
No full textProfessor Alfredo Falcone and Dr Lisa Salvatore speak to Roshaine Gunawardana, Managing Commissioning Editor: Professor Alfredo Falcone is the Director of the Department of Oncology and the Specialization School at the University Hospital of Pisa, Italy. He trained in Pisa and Genoa, Italy, and has held major positions in Italian oncology since 2000. He currently has more than 300 publications, including papers in peer-reviewed international and national journals, book chapters, and more than 600 abstracts of presentations to international and national conferences. The majority of his papers regard clinical and translational research, with a particular focus on metastatic colorectal cancer. Dr Lisa Salvatore is a medical oncologist in the Department of Translational Research and New Technologies in Medicine and Surgery at the University of Pisa. She has been an author on about 40 publications in major peer-reviewed publications and has made numerous presentations in national and international conferences. Her main interest is focused on clinical and translational research in metastatic colorectal cancer
- …
