1,721,017 research outputs found
OPEN FIXATION OF DISTAL RADIUS FRACTURES: OUR EXPERIENCE
No full textDistal radius fractures are the most frequent lesions encountered during clinical practice. They have been treated with close reduction and plaster cast immobilization for long time. Actually, many authors emphasized the importance of anatomical reduction and surgical stabilization of the fracture. Internal fixation with plates is the gold standard for displaced extra-articular and intra-articular distal radial fractures. Stable internal fixation permits early motion of the wrist and of the surrounding joints and allows better functional rehabilitation of the wrist-hand complex. Between April 2006 and June 2010 we treated 77 distal radius fractures by open reduction and internal fixation using titanium low-profile angular stability volar plate. On the 15th day we started a gradual articular mobilization. The patients underwent follow-up at 1 and 3 months from the surgery and were examinated by radiographs. Functional outcomes were documented measuring the range of movement and the grip strength and by Gartland-Werley demerit point scoring system modified Sarmiento, the Disability of the Arm, Shoulder and Hand (DASH) and the Patient-Rated Wrist Evaluation (PRWE) questionnaire. Our results show a good recovery of range of movement and grip strength without pain. Open reduction and internal fixation with low profile angular stability volar plates represent an efficient and safe procedure to treat distal radius fractures. Stable reduction permits early mobilization strongly required for good functional outcome
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Analisi di linkage in famiglie con ricorrenza di displasia evolutiva dell’anca. Esclusione dei loci COL2A1 e VDR
No full textLa displasia evolutiva dell’anca (DDH) è una delle più comuni malformazioni congenite. Si presenta con ampio spettro di anormalità di collocazione della testa femorale nell’acetabolo, il cui grado di severità varia dalla semplice instabilità alla dislocazione completa. La DDH può manifestarsi nel contesto di condizioni sindromiche, ma più spesso si presenta come malformazione isolata, con una incidenza in Italia di circa 10 nuovi casi ogni 1000 nascite. Malgrado la rilevanza di questa condizione malformativa, ben poco si conosce riguardo alle sue cause.
La DDH isolata viene inquadrata come condizione multifattoriale, alla quale concorrono fattori di rischio ambientale e fattori genetici di suscettibilità. Le cause ambientali comprendono essenzialmente condizioni legate alla gravidanza (oligoidramnios, presentazione podalica, livelli di relaxina), mentre quelle genetiche sono pressoché sconosciute. In un recente studio caso-controllo in pazienti con osteoartite secondaria a DDH era stata dimostrata associazione con varianti nei geni COL2A1 e VDR, localizzati in 12q13.11
Allo scopo di esplorare il ruolo di COL2A1 e VDR nella DDH isolata, abbiamo analizzato 11 famiglie con ricorrenza di DDH utilizzando marcatori multiallelici che coprono la regione q12-q13.13 del cromosoma 12. L’analisi del lod-score multipoint è stata eseguita mediante genehunter. I profili di lod score ottenuti, sia nel modello dominante che in quello recessivo o nel modello non-parametrico, sono risultati ampiamente negativi, indicando che nelle famiglie studiate la regione cromosomica presa in esame non è in linkage con la DDH
Recurrent, spontaneous, postoperative small bowel perforations caused by invasive candidiasis.
No full textTRABECULAR TITANIUM INDUCES OSTEOBLASTIC BONE MARROW STEM CELLS DIFFERENTIATION
No full textPure titanium and titanium alloys are materials widely used in orthopedics and dental surgery because of their mechanical properties, chemical stability and biocompatibility. Although excellent clinical results have been shown, traditional porous metals have several inherent limitations (low volumetric porosity, relatively high modulus of elasticity and availability as a coating only). With the aim of going over these limits, improving the potentiality of osteointegration, a new highly porous titanium biomaterial (Trabecular TitaniumTM, TT) has been developed. Because the molecular events due to TT and able to alter osteoblast activity to promote bone formation are poorly understood, expression of osteoblastic related genes in mesenchymal stem cells exposed to TT was investigated. The expression levels of bone related genes like RUNX2, SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (CD105) were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. TT causes induction of bone related genes osteopontin (SPP1), osteocalcin (BGLAP) alkaline phosphatase (ALPL) and indicating the differentiation effect of this biomaterial on mesenchymal stem cells. The obtained results can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effect
AN IN VITRO STUDY ABOUT THE EFFECT OF ENGIPORE® ON DENTAL PULP STEM CELLS
No full textEngipore® is a porous hydroxyapatite (HA) biomaterial with a trabecular structure similar to natural bone.
We analyzed the quantitative expression of mRNA of specific genes, first in DPSCs and then in Human Osteoblasts (HOb), after 15 and 30 days of treatment with Engipore®, to detect if this biomaterial stimulates Dental Pulp Stem Cells (DPSCs) towards osteoblast differentiation.
The obtained results demonstrated that Engipore® induces osteoblast phenotype expression and extracellular matrix deposition and mineralization in DPSCs, by the activation of osteoblast related genes SPP1, RUNX2 and FOSL1
Genetic effect of zirconium oxide coating on osteoblast-like cells
No full textZirconium is widely used as material for prosthetic devices because its good mechanical and chemical properties. When exposed to oxygen, zirconium becomes zirconium oxide (ZrO(2)), which is biocompatible. ZrO(2) can be also prepared as a colloidal suspension and then used to coat surfaces. Zirconium oxide coating (ZrO(2)C) can potentially have specific biologic effects, and among them is bone formation related to implant osseointegration. How this biomaterial alters osteoblast activity to promote bone formation is poorly understood. We therefore attempted to address this question by using microarray techniques to identify genes that are differently regulated in osteoblasts exposed to ZrO(2)C. By using DNA microarrays containing 20,000 genes, we identified in osteoblast-like cell lines (MG-63) cultured with ZrO(2)C several genes whose expression was significantly upregulated or downregulated. The differentially expressed genes cover a broad range of functional activities: (a) cell cycle regulation, (b) signal transduction, (c) immunity, and (d) cytoskeleton component. The data reported are, to our knowledge, the first genetic portrait of ZrO(2)C effects. They can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects
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