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    Physiologic Changes in the Acute Asthmatic Attack

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    Dr Solbert Permutt, 1925–2012

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    Bronchial Hyperresponsiveness

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    Static pressure-volume characteristics of lungs in normal males

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    The static pressure-volume characteristics of the lungs were determined in 28 normal males between the ages of 21 and 76 years. Transpulmonary pressures were measured in relation to absolute lung volumes throughout the entire range of the vital capacity, both on inspiration and expiration. There was an increase in residual volume and a decrease in vital capacity, but no change in the slope or position of the pressure-volume curve with advancing age. It appeared that the older subjects were unable to change transpulmonary pressure between residual volume and total lung capacity to the same extent as the younger subjects. The results suggest that with advancing age there is little change in the intrinsic static pressure-volume characteristics of the lungs themselves, and that all of the significant changes with age are more likely due to changes in either the compliance or muscle power of the thorax. Submitted on December 24, 1959 </jats:p

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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