1,721,153 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck
No full textPurpose: Squamous cell carcinomas of theheadandneck(HNSCC) oftenharbor p53mutations,
but p53 protein degradation by the viral oncoprotein E6 may supercede p53 mutations in human
papillomavirus 16 (HPV16)^ positive tumors. The prevalence of p53 mutations in HPV-positive
HNSCCs is indeed lower, but in some tumors these alterations coexist.The purpose of this study
was to discernwhetherHNSCCs differ in the type ofp53 mutations as a function ofHPV16 status.
Experimental Design: The study was nested within a prospective multicenter study (ECOGE
4393/RTOGR9614) of patients with HNSCC treated surgically with curative intent.Tumors from
one study center were used to construct a tissue microarray.The tumors were well characterized
with respect to p53 mutational status. The tissue microarray was evaluated by HPV16 in situ
hybridization. HPV16 analysis was also done on a select group of tonsillar carcinomas known to
harbor disruptive p53 mutations defined as stop mutations or nonconservative mutations within
the DNA binding domain.
Results: HPV16 was detected in12 of 89 (13%) HNSCCs. By tumor site, HPV16 was detected in
12 of 21 (57%) tumors fromthe palatine/lingual tonsils, but in none of 68 tumors fromnontonsillar
sites (P < 0.00001). Both HPV16-positive and HPV16-negative HNSCCs harbored p53 mutations
(25% versus 52%), but disruptive mutations were only encountered in HPV16-negative
carcinomas. Of seven tonsillar carcinomas with disruptive p53 mutations, none were HPV16 positive,
in contrast to HPV16-positive tonsillar carcinomas without disruptive p53 mutations (0%
versus 57%; P = 0.008).
Conclusions: Although HPV16 and mutated p53 may coexist in a subset of HNSCCs, HPV16
and disruptive p53 mutations seem to be nonoverlapping events. A less calamitous genetic profile,
including the absence of disruptive p53 mutations, may underlie the emerging clinical profile
of HPV16-positive HNSCC such as improved patient outcome
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis
No full textDispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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