1,721,014 research outputs found
Pengaruh Pemberian Curcumin Terhadap Perubahan Klinis Efek Samping Pada Pasien Tuberkulosis Dalam Pengobatan Kategori 1 Fase Intensif.
No full textBackground and Aim: Patients with pulmonary tuberculosis often experience gastrointestinal complaints such as nausea, vomiting and drug-induced liver injury characterized by increased liver function tests due to the hepatotoxic effects of several anti-tuberculosis drugs, which are especially experienced in the first 2 months of treatment. Curcuma has long been known to have a hepatoprotector effect and improve liver function. This study aims to determine the effect of curcuma on improving liver value function tests and gastrointestinal side effects in pulmonary TB patients after 2 months of intensive phase.
Methods: This is an experimental study conducted from April to June 2019 in 100 pulmonary TB patients divided into two groups. The first group received Curcuma once a day for 2 months, and the second group as a control group. Liver function test and evaluation of gastrointestinal side effects were assesed before and after the intensive phase. Statistical analysis was carried out by Chi Square test using SPSS software.
Results: A total of 60 men and 40 women were enrolled in this study. After giving Curcuma for 2 months, there were no significant differences in the levels of Bilirubin, ALT and AST in both groups, which are 0.5 mg/dl, 25.6 mg/dl and 31.2 mg/dl respectively in groups 1 and 0.55 mg/dl, 26.9 mg/dl and 31.02 mg/dl respectively in the control group (p>0.05). There were significant differences in complaints of nausea and vomiting experienced by patients, where 75% in group 1 and 25% in the control group experienced improvement in symptoms (p = 0.02).
Conclusions: There was a significant relationship between curcuma administration and improvement of gastrointestinal symptoms such as nausea and vomit, but did not affect the value of liver function test such as Bilirubin, AST and ALT.Latar Belakang dan tujuan : Pasien dengan tuberkulosis paru sering mengalami keluhan gastrointestinal seperti mual, muntah dan drug-induced liver injury yang ditandai peningkatan nilai liver function test akibat efek hepatotoksik dari beberapa anti-tuberculosis drugs, yang terutama dialami dalam 2 bulan pertama pengobatan. Curcuma telah lama diketahui memiliki efek hepatoprotektor dan memperbaiki fungsi liver. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian curcuma terhadap perbaikan nilai liver function test dan efek samping gastrointestinal pada pasien TB paru setelah 2 bulan fase intensif.
Metode : Penelitian ini merupakan studi eksperimental yang dilakukan dari bulan April sampai Juni 2019 pada 100 pasien TB paru yang dibagi menjadi dua kelompok. Kelompok pertama mendapatkan Curcuma sekali sehari selama 2 bulan, dan kelompok kedua sebagai kelompok kontrol. Dilakukan penilaian liver function test dan evaluasi efek samping gastrointestinal sebelum dan sesudah fase intensif. Analisis statistik dilakukan dengan uji Chi Square menggunakan software SPSS.
Hasil : Sebanyak 60 orang laki-laki dan 40 orang perempuan enrolled in this study. Setelah pemberian Curcuma selama 2 bulan, tidak terdapat perbedaan yang signifikan kadar Bilirubin, ALT dan AST pada kedua kelompok, yaitu 0.5 mg/dl, 25.6 mg/dl dan 31.2 mg/dl respectively pada kelompok 1 dan 0.55 mg/dl, 26.9 mg/dl dan 31.02 mg/dl respectively pada kelompok kontrol (p>0.05). Terdapat perbedaan yang signifikan pada keluhan mual dan muntah yang dialami pasien, dimana 75% pada kelompok 1 dan 25% pada kelompok kontrol mengalami perbaikan gejala (p=0.02).
Kesimpulan : Terdapat hubungan yang signifikan antara pemberian curcuma dengan perbaikan gejala gastrointestinal yaitu mual dan muntah, tetapi tidak mempengaruhi nilai kadar fungsi hati yaitu Bilirubin, SGOT dan SGPT.99 HalamanTesis Magiste
Pengaruh Pemberian Curcumin Terhadap Konversi Sputum pada Pasien Tuberkulosis Dalam Pengobatan Kategori 1 Fase Intensif
No full textBackground and Aim: Patients with pulmonary tuberculosis often experience gastrointestinal complaints such as nausea, vomiting and drug-induced liver injury which results in impaired absorption and metabolism of anti-tuberculosis drugs, especially in the intensive phase. It will be feared that it will reduce the potential for drug work and result in delaying improvement of chest x-ray and sputum conversion. Curcumin has long been known to have a hepatoprotector effect and improve liver function in patients receiving anti-tuberculosis drugs so that it is expected to be able to increase the potential for drug work. The aim of this study is to evaluate the effect of Curcumin on sputum conversion in patients with pulmonary tuberculosis after the first 2-month treatment.
Methods: We conducted an experimental study in April to June 2019 in 100 pulmonary TB patients divided into two groups. The first group received Curcumin once daily for 2 months, and the second group as a control group. An assessment of AFB-smear sputum before and after the intensive phase. Statistical analysis was carried out by Chi Square test using SPSS software
Results: A total of 60 men and 40 women were enrolled in this study. After administration of Curcumin for 2 months, in terms of sputum conversion, there were significant differences between the two groups. 60% of group 1 experienced sputum conversion to negative AFB, compared to 40% of group 2 (p = 0.04; OR 2.2 95% CI 1.01 - 5.0).
Conclusions: There was a significant relationship between Curcumin administration and sputum conversion in intensive phase of pulmonary TB patients.Latar Belakang dan tujuan : Pasien dengan tuberkulosis paru sering mengalami keluhan gastrointestinal seperti mual, muntah dan drug-induced liver injury yang mengakibatkan gangguan absorbsi dan metabolisme anti-tuberculosis drugs, terutama pada fas eintensif. Hal ini akan dikhawatirkan akan mengurangi potensi kerja obat dan berakibat pada delay perbaikan chest x-ray dan konversi sputum. Curcumin telah lama diketahui memiliki efek hepatoprotektor dan memperbaiki fungsi liver pada pasien yang mendapat anti-tuberculosis drugs sehingga diharapkan mampu meningkatkan potensi kerja obat. Tujuan penelitian ini adlaah untuk mengevaluasi hubungan pemberian Curcumin terhadap konversi sputum pada pasien TB paru setelah 2 bulan fase intensif.
Metode : Penelitian ini merupakan studi eksperimental yang dilakukan dari bulan April sampai Juni 2019 pada 100 pasien TB paru yang dibagi menjadi dua kelompok. Kelompok pertama mendapatkan Curcumin sekali sehari selama 2 bulan, dan kelompok kedua sebagai kelompok kontrol. Dilakukan penilaian hapusan BTA sebelum dan sesudah fase intensif. Analisis statistik dilakukan dengan uji Chi Square menggunakan software SPSS.
Hasil : Sebanyak 60 orang laki-laki dan 40 orang perempuan. Setelah pemberian Curcumin selama 2 bulan, dalam hal konversi sputum, terjadi perbedaan yang signifikan antara kedua kelompok. Sebanyak 60% dari kelompok 1 mengalami konversi sputum menjadi AFB negatif, dibandingkan 40% dari kelompok 2 (p=0.04; OR 2.2 95%CI 1.01 – 5.0).
Kesimpulan : Terdapat hubungan yang signifikan antara pemberian Curcumin dengan konversi sputum penderita TB paru fase intensif.104 HalamanTesis Magiste
Kadar Prokalsitonin pada Pasien Tuberkulosis Paru yang BTA Positif dan BTA Negatif
No full textLatar Belakang
Tuberkulosis adalah suatu penyakit menular yang di sebabkan oleh Mycobacterium
tuberculosis yang masuk dalam bentuk droplet nuklei ke dalam mulut atau saluran
hidung, saluran pernafasan bagian atas, dan bronkus untuk mencapai alveoli paruparu.
Berdasarkan hasil pemeriksaan dahak BTA di bagi tuberkulosis paru BTA
positif dan BTA negatif. Diferensiasi penyebab infeksi paru menjadi sangat penting
guna membatasi penggunaan antibiotik. Diagnosis pasti untuk tuberkulosis harus
menunggu hasil kultur sputum yang lama. Oleh sebab itu, dibutuhkan suatu penanda
spesifik yang mampu mendeteksi infeksi bakteri dengan cepat. Prokalsitonin ( PCT )
terdiri dari 116 asam amino dengan berat molekul ±13 kDa, protein ini dikode oleh
gen CALC-1 yang terletak pada kromosom 11 dan diproduksi sel C kelenjar tiroid
sebagai prohormon kalsitonin dan merupakan suatu biomarker yang lebih spesifik
terhadap infeksi bakteri.
Metode
Penelitian ini di lakukan dengan metode cross sectional. Subyek penelitian ini adalah
semua pasien laki-laki dan perempuan yang berusia ≥ 18 tahun, yang secara klinis (
gejala, gambaran radiologi, pemeriksaan sputum BTA positif maupun negatif ),
dengan sampel berjumlah 40 pasien tuberkulosis paru, yang terdiri dari 20 BTA
positif dan 20 BTA negatif. Pemeriksaan prokalsitonin dengan mini VIDAS
BRAHMS dilakukan dengan prinsip Sandwich menggunakan metode ELFA ( Ezyme
Linked Flourescent Assay ). Pemeriksaan sputum dilakukan dengan pewarnaan BTA
cara Zhiel Neelsen.
Hasil
Kadar prokalsitonin pada pasien tuberkulosis paru dengan BTA positif ( 0,1550;
21,65 ) berbeda secara signifikan dengan kadar prokalsitonin pada pasien
tuberkulosis paru dengan BTA negatif ( 0,05; 3,14 ) dengan p = 0,0001. Nilai cut off
0,06 ng/mL di dapatkan dari hasil penelitian dengan nilai sensitivitas 80 % dan
spesifisitas 80 %.
Kesimpulan
Terdapat perbedan yang signifikan kadar prokalsitonin pada pasien tuberkulosis paru
yang BTA positif dan BTA negatif.Background
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis which
enters the droplet nuclei into the mouth or nasal passages, upper respiratory tract, and
bronchi to reach the pulmonary alveoli. Based on the results of sputum smear
examination for smear positive and negative smear pulmonary tuberculosis.
Differentiation of causes of pulmonary infection becomes very important in order to
limit the use of antibiotics. The exact diagnosis for tuberculosis must wait for the
results of the old sputum culture. Therefore, a specific marker is needed that is able to
detect bacterial infections quickly. Procalcitonin (PCT) consists of 116 amino acids
with a molecular weight of ± 13 kDa, this protein is encoded by the CALC-1 gene
located on chromosome 11 and produced C thyroid gland cells as a prohormone
calcitonin and is a biomarker that is more specific to bacterial infections.
Methods
This research was conducted with a cross sectional method. The subjects of this study
were all male and female patients aged ≥ 18 years, who were clinically (symptoms,
radiological features, positive and negative smear sputum examination), with a sample
of 40 pulmonary tuberculosis patients, consisting of 20 positive smear and 20
Negative smear. Procalcitonin examination with mini VIDAS BRAHMS was carried
out using the Sandwich principle using the ELFA method (Ezyme Linked Flourescent
Assay). Sputum examination was carried out by smear coloring by Zhiel Neelsen
method.
Results
Procalcitonin levels in pulmonary tuberculosis patients with positive smear (0.1550;
21.65) differ significantly from procalcitonin levels in patients with pulmonary
tuberculosis with negative smear (0.05; 3.14) with p = 0.0001. The cut off value of
0.06 ng / mL was obtained from the results of the study with a sensitivity value of
80% and specificity of 80%.
Conclusion
There was a significant difference in the level of procalcitonin in patients with
pulmonary tuberculosis who were smear positive and smear negative.123 HalamanTesis Magiste
Pengaruh Pemberian Curcumin Terhadap Perubahan Klinis Efek Samping Pada Pasien Tuberkulosis Dalam Pengobatan Kategori 1 Fase Intensif.
No full textBackground and Aim: Patients with pulmonary tuberculosis often experience gastrointestinal complaints such as nausea, vomiting and drug-induced liver injury characterized by increased liver function tests due to the hepatotoxic effects of several anti-tuberculosis drugs, which are especially experienced in the first 2 months of treatment. Curcuma has long been known to have a hepatoprotector effect and improve liver function. This study aims to determine the effect of curcuma on improving liver value function tests and gastrointestinal side effects in pulmonary TB patients after 2 months of intensive phase.
Methods: This is an experimental study conducted from April to June 2019 in 100 pulmonary TB patients divided into two groups. The first group received Curcuma once a day for 2 months, and the second group as a control group. Liver function test and evaluation of gastrointestinal side effects were assesed before and after the intensive phase. Statistical analysis was carried out by Chi Square test using SPSS software.
Results: A total of 60 men and 40 women were enrolled in this study. After giving Curcuma for 2 months, there were no significant differences in the levels of Bilirubin, ALT and AST in both groups, which are 0.5 mg/dl, 25.6 mg/dl and 31.2 mg/dl respectively in groups 1 and 0.55 mg/dl, 26.9 mg/dl and 31.02 mg/dl respectively in the control group (p>0.05). There were significant differences in complaints of nausea and vomiting experienced by patients, where 75% in group 1 and 25% in the control group experienced improvement in symptoms (p = 0.02).
Conclusions: There was a significant relationship between curcuma administration and improvement of gastrointestinal symptoms such as nausea and vomit, but did not affect the value of liver function test such as Bilirubin, AST and ALT.Latar Belakang dan tujuan : Pasien dengan tuberkulosis paru sering mengalami keluhan gastrointestinal seperti mual, muntah dan drug-induced liver injury yang ditandai peningkatan nilai liver function test akibat efek hepatotoksik dari beberapa anti-tuberculosis drugs, yang terutama dialami dalam 2 bulan pertama pengobatan. Curcuma telah lama diketahui memiliki efek hepatoprotektor dan memperbaiki fungsi liver. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian curcuma terhadap perbaikan nilai liver function test dan efek samping gastrointestinal pada pasien TB paru setelah 2 bulan fase intensif.
Metode : Penelitian ini merupakan studi eksperimental yang dilakukan dari bulan April sampai Juni 2019 pada 100 pasien TB paru yang dibagi menjadi dua kelompok. Kelompok pertama mendapatkan Curcuma sekali sehari selama 2 bulan, dan kelompok kedua sebagai kelompok kontrol. Dilakukan penilaian liver function test dan evaluasi efek samping gastrointestinal sebelum dan sesudah fase intensif. Analisis statistik dilakukan dengan uji Chi Square menggunakan software SPSS.
Hasil : Sebanyak 60 orang laki-laki dan 40 orang perempuan enrolled in this study. Setelah pemberian Curcuma selama 2 bulan, tidak terdapat perbedaan yang signifikan kadar Bilirubin, ALT dan AST pada kedua kelompok, yaitu 0.5 mg/dl, 25.6 mg/dl dan 31.2 mg/dl respectively pada kelompok 1 dan 0.55 mg/dl, 26.9 mg/dl dan 31.02 mg/dl respectively pada kelompok kontrol (p>0.05). Terdapat perbedaan yang signifikan pada keluhan mual dan muntah yang dialami pasien, dimana 75% pada kelompok 1 dan 25% pada kelompok kontrol mengalami perbaikan gejala (p=0.02).
Kesimpulan : Terdapat hubungan yang signifikan antara pemberian curcuma dengan perbaikan gejala gastrointestinal yaitu mual dan muntah, tetapi tidak mempengaruhi nilai kadar fungsi hati yaitu Bilirubin, SGOT dan SGPT.99 HalamanTesis Magiste
Uji Diagnostik Genexpert MTB/RIF di Rumah Sakit Umum Pusat Haji Adam Malik Medan
No full textCases of multidrug resistant tuberculosis (MDR TB) is increasing in number in the world and requires early detection to prevent further transmission. GeneXpert MTB/RIF is a tool that can be used for detection of rifampicin resistance, as a surrogate marker for multidrug-resistant tuberculosis. This study aims to assess the sensitivity and specificity of the GeneXpert MTB/RIF in the diagnosis of MDR TB. The study was conducted at a poly MDR TB General Hospital Haji Adam Malik Medan. The subjects were all suspected MDR TB who had results positive GeneXpert MTB/RIF with sensitive rifampin or resistant rifampin and had a drug sensitivity test results with the proportion method Lowenstein Jensen medium. Data retrieved from the medical records of the period of January to December 2013, founded 64 samples that had results of GeneXpert MTB/RIF test positive and had the results of drug sensitivity, 87.5% of rifampin-resistant samples were also resistant to isoniazid. The GeneXpert MTB/RIF examination showed sensitivity of 92.86% and specificity of 59.09%. The Conclusion: GeneXpert MTB/RIF has a high sensitivity for diagnosing MDR TB against the gold standard drug sensitivity testing proportion method on Lowenstein Jensen medium. This study recommends the GeneXpert MTB/RIF be used for MDR TB screening tool.Kasus multidrug resistant tuberculosis (MDR TB/TB MDR) semakin meningkat jumlahnya di dunia dan memerlukan deteksi dini untuk mencegah penyebaran yang lebih lanjut. GeneXpert MTB/RIF adalah alat yang dapat digunakan untuk mendeteksi resistensi rifampisin, sebagai tanda pengganti untuk TB MDR. Penelitian ini merupakan uji diagnostik yang bertujuan untuk menilai sensitivitas dan spesifisitas GeneXpert MTB/RIF dalam mendiagnosa TB MDR. Penelitian dilakukan di poli TB MDR Rumah Sakit Umum Pusat Haji Adam Malik Medan. Subjek penelitian adalah semua suspek penderita TB MDR yang mempunyai hasil GeneXpert MTB/RIF positif baik resisten rifampisin maupun sensitif rifampisin dan mempunyai hasil uji kepekaan obat metode proporsi dengan media Lowenstein Jensen. Data diambil dari rekam medik periode Januari sampai dengan Desember 2013, didapatkan 64 sampel yang mempunyai hasil GeneXpert MTB/RIF positif dan mempunyai hasil uji kepekaan obat, 87,5% sampel yang resisten rifampisin juga resisten terhadap isoniazid. Pemeriksaan GeneXpert MTB/RIF menunjukkan sensitivitas 92,86% dan spesifisitas 59,09%. Kesimpulan: GeneXpert MTB/RIF mempunyai sensitivitas tinggi untuk mendiagnosa TB MDR terhadap baku emas uji kepekaan obat metode proporsi pada media Lowenstein Jensen. Penelitian ini menganjurkan GeneXpert MTB/RIF digunakan sebagai alat skrining TB MDR.87 HalamanTesis Magiste
Hubungan Faal Paru terhadap Derajat Keparahan Covid-19 pada Penyintas Covid-19 yang Bekerja di Rumah Sakit Advent Medan
Full text linkBackground: The high recovery rate for patients who are high after being infected with COVID-19 still leaves problems with the post-COVID-19 syndrome which is a new problem. Persistent shortness of breath and fatigue are symptoms that often appear in patients with post-COVID-19 syndrome, which indicates involvement of the pulmonary and respiratory organ systems. Of course ,this requires a more objective examination in determining the state of lung function.
Methods: This research is a descriptive cross-sectional study, in which data were collected through interviews using questionnaires and pulmonary function examination. Research participants are COVID-19 survivors who work at Medan Adventist Hospital
Result: Of the 89 samples that met the inclusion criteria, 13 people (14.6%) had post-COVID-19 syndrome symptoms, with the most complaints being fatigue, as many as 10 people (11.2%). 21 samples with restrictive interference. 16 people who have a restrictive disorder with a mild degree of COVID-19. 5 people who experience restrictive disorders with moderate-severe degrees of COVID-19.
Conclusion: There was no significant relationship between lung function disorders and the severity of COVID-19 in this study (p = 0.333).111 HalamanTesis Magiste
Identifikasi Mutasi Gen rpoB, katG dan embB Penyebab Multidrug Resistance Tuberkulosis di Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik
No full textCase of resistance has long been a challenge in the preventive program Tuberculosis (TB) and Multidrug Resistance Tuberculosis (MDR-TB). Microbial resistance to antibiotics is an innate characteristic of Mycobacterium tuberculosis (M. tuberculosis). It is associated with a genetic mutation that occurs naturally in a large population of wild-type M. tuberculosis that antibiotics have never been used and does not cause clinical symptoms. The purpose of the study were to assess gene mutations in M. tuberculosis causes resistance to rifampicin, isoniazid and ethambutol in MDR-TB patients in the Haji Adam Malik Hospital, to determine how the mutated of codon in the rpoB, katG, and embB genes, determine the suitability of the general pattern of mutations that occur in patients with MDR-TB in the hospital with global mutation pattern.
This observational study was performed prospectively in patients with MDR-TB who had data medical records results of GeneXpert MTB / RIF positive for resistant to rifampicin period August to November 2016 in the hospital by taking sputum from patients, then detected using Polymerase Chain Reaction (PCR) in the Integrated Laboratory of Faculty of Medicine, University of Sumatera Utara. The PCR products were analyzed using gel electrophoresis and visualized using Gel Documentation. DNA bands formed, and their size were determined by molecular size marker expressed by base pair.
The highest percentage of 81 bp rpoB gene mutation M. tuberculosis called as rifampicin-resistance determining region (RRDR) which was located at codon 516 (100%) then at codon 531 (96.77%), and codon 526 (90.32%); while the smallest percentage was 81 bp rpoB gene mutation at codon 533 M. tuberculosis (12.90%). A total of 83.87% of the sample experienced M. tuberculosis katG gene mutation at codon 315 resulting in resistance to INH and these samples as well as resistance to rifampicin. A total of 29.03% of the samples had mutations in the gene embB M. tuberculosis codon 306A that caused resistance to ethambutol.Kasus resistensi merupakan kasus yang sejak lama menjadi tantangan dalam program penanggulangan Tuberkulosis (TB) dan pencegahan peningkatan kasus TB resisten obat menjadi prioritas utama. Resistensi mikroba terhadap antibiotik merupakan karakteristik bawaan (innate) Mycobacterium tuberculosis. Hal ini berhubungan dengan mutasi genetik yang terjadi secara alamiah pada sebagian besar populasi M. tuberculosis wild type yaitu antibiotik belum pernah digunakan dan tidak menimbulkan gejala klinis. Adapun tujuan penelitian adalah untuk mengetahui mutasi pada gen M. tuberculosis penyebab resistensi terhadap rifampicin, isoniazid, dan etambutol pada pasien Multidrug Resistance Tuberkulosis (MDR-TB) di Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik Medan, menentukan kodon mana yang bermutasi pada gen rpoB, gen katG, dan gen embB, menentukan kesesuaian pola mutasi umum yang terjadi pada pasien MDR-TB di RSUP Haji Adam Malik Medan dengan pola mutasi global.
Penelitian ini merupakan penelitian observasional dan dilakukan secara prospektif pada pasien MDR-TB yang mempunyai data catatan medik hasil dari GeneXpert MTB/RIF positif resisten terhadap rifampisin periode Agustus sampai November 2016 di RSUP Haji Adam Malik Medan dengan pengambilan sputum dari pasien, kemudian dideteksi menggunakan metode molekuler Polymerase Chain Reaction (PCR) di Laboratorium Terpadu Fakultas Kedokteran Universitas Sumatera Utara. Produk PCR dianalisis menggunakan elektroforesis gel dan divisualisasi menggunakan Gel Documentation. Pita DNA terbentuk dan ukurannya dapat diketahui berdasarkan penanda ukuran molekul yang dinyatakan dengan base pair.
Persentase tertinggi mutasi gen 81 bp rpoB M. tuberculosis atau pada daerah rifampicin resistance-determining region (RRDR) yaitu terdapat pada kodon 516 (100%) kemudian pada kodon 531 (96,77%), dan kodon 526 (90,32%); sedangkan persentase terkecil yaitu mutasi gen 81 bp rpoB M. tuberculosis pada kodon 533 (12,90%). Sebanyak 83,87% sampel mengalami mutasi gen katG M. tuberculosis pada kodon 315 yang mengakibatkan resistensi terhadap INH dan sampel tersebut juga resistensi terhadap rifampisin. Sebanyak 29,03% sampel mengalami mutasi gen embB M. tuberculosis di kodon 306A yang menimbulkan resistensi terhadap etambutol.113 HalamanTesis Magiste
Kadar Interleukin 17 Sebagai Biomarker dalam Perbaikan Pengobatan Tb Paru Sebelum Pengobatan dan Setelah 2 Bulan Pengobatan OAT
No full textBackground
Tuberculosis (TB) is an important public health problem in the world. Indonesia ranks third in the world after China and India. The cause of TB is Mikrobakterium tuberculosis.
This disease is the result of chronic interactions between intracellular microorganisms and the immune system response. Interleukin 17 (IL-17) is a cytokine that plays an important role in the pathogenesis of TB. These cytokines are able to regulate the antibacterial activity and inflammatory processes to fight further infections from Mycobacterium Tuberculosis.
The success of TB control is highly dependent on the diagnosis and appropriate treatment and evaluating its treatment. Many TB sufferers who are undergoing further treatment of OAT have difficulty sputum removal for acid-resistant bacillus smear examination, so that the therapeutic monitor is not optimal
Aim
Analyzing changes in IL-17 levels in smear positive pulmonary TB patients before treatment and after 2 months of receiving anti-tuberculosis drug treatment (OAT).
Method
Observational research with a cohort - prospective data collection method. Thirty subjects with positive smear pulmonary TB were taken blood samples, before treatment and after 2 months of OAT treatment to assess changes in IL-17 levels
Results
Of 30 patients with positive smear pulmonary TB disease, the IL value of 17 before receiving OAT treatment was 75.2 (11.3 - 281.0) and after 2 months of treatment decreased to 35.1 (4.7 - 141.2) with P <0.05. By using the Spearman correlation obtained a significant correlation between IL-17 levels before and after treatment (p <0.05) and r = 0.72,
Conclusion
From the results of the study concluded that there were significant differences in IL-17 levels before and after two months of intensive phase treatment.Latar Belakang
Tuberkulosis (TB) merupakan masalah kesehatan masyarakat yang penting di dunia. Indonesia menempati urutan ke-3 terbanyak di dunia setelah Cina dan India. Penyebab TB adalah Mikrobakterium tuberculosis. Penyakit ini merupakan hasil dari interaksi kronis antara mikroorganisme intraseluler dan respon sistem imun. Interleukin 17 (IL-17) adalah sitokin yang berperan penting dalam patogenesis TB. Sitokin ini mampu mengatur aktivitas antibakteri dan proses inflamasi untuk melawan infeksi lebih lanjut dari kuman Mycobacterium Tuberculosis. Keberhasilan pengendalian penyakit TB sangat tergantung pada diagnosis dan pengobatan yang tepat dan mengevaluasi pengobatannya. Banyak penderita TB yang sedang menjalani pengobatan lanjutan OAT mengalami kesulitan mengeluarkan sputum untuk pemeriksaan hapusan basil tahan asam (BTA) , sehingga monitor terapi menjadi tidak maksimal. Oleh karena itu, pada penelitian ini dilakukan pemeriksaan kadar IL-17 serum sebelum pengobatan dan sesudah 2 bulan pengobata OAT untuk mengetahui hubungannya dengan konversi BTA sputum dan keberhasilan terapi.
Tujuan
Menganalisis perubahan kadar IL – 17 pada penderita TB paru BTA positif sebelum pengobatan dan setelah2 bulan mendapat pengobatan obat anti tuberkulosis ( OAT ).
Metode
Penelitian observasional dengan metode pengumpulan data secara kohort – prospective. Sebanyak 30 orang subjek dengan penyakit TB paru BTA positif diambil sampel darahnya, sebelum pengobatan dan setelah 2 bulan pengobatan OAT untuk menilai perubahan kadar IL-17
Hasil
Dari 30 orang pasien dengan penyakit TB paru BTA positif didapat kan nilai IL 17 sebelum mendapatkan pengobatan OAT adalah 75.2 ( 11.3 - 281.0) dan setelah 2 bulan pengobatan menurun menjadi 35.1 (4.7 - 141.2) dengan P< 0.05. Dengan menggunakan menggunakan korelasi Spearman didapatkan korelasi yang signifikan antara kadar IL-17 sebelum dan sesudah pengobatan (p<0.05) dan r=0.72,
Kesimpulan
Dari hasil penelitian maka disimpulkan bahwa Terdapat perbedaan yang signifikan kadar IL-17 sebelum dan sesudah dua bulan pengobatan fase intensif.102 HalamanTesis Magiste
Kejadian TB Resistansi Primer pada Fasilitas Pelayanan Kesehatan di Kota Medan Tahun 2015
No full textResistansi terhadap obat anti tuberkulosis merupakan tantangan bagi program pencegahan dan pengendalian tuberkulosis (TB) di dunia.Kasus resistansi yang dirujuk ke rumah sakit sebagian besar berasal dari fasilitas pelayanan kesehatan. Belum banyak data kejadian TB resistansi primer di fasilitas pelayanan kesehatan. Tujuan penelitian ini adalah untuk mengetahui proporsi kejadian TB resistansi primer pada fasilitas pelayanan kesehatan di Kota Medan.Penelitian ini merupakan penelitian deskriptif. Penelitian ini dilakukan di fasilitas pelayanan kesehatan (puskesmas dan dokter praktik swasta) mulai Februari sampai Agustus 2015. Subyek penelitian ini adalah penderita TB paru yang tidak memiliki riwayat pengobatan obat anti tuberkulosis (OAT) atau pernah mendapat pengobatan OAT kurang dari satu bulan. Subyek penelitian dikumpulkan data demografi, keluhan utama kemudian dilakukan pemeriksaan sputum (mikroskopis), radiologis, kultur dan uji kepekaan obat sebelum mendapat terapi OAT.Dari 31 subyek penelitian yang diteliti didapat resistansi primer sebesar 3 orang (9,68%). Monoresistan primer sebanyak 2 orang (6,45%) pada jenis obat isoniazid. TB MDR primer sebanyak 1 orang (3,23%) dengan kombinasi resistansi obat rifampisin, isoniazid dan etambutol.Kesimpulan: Didapatkan angka resistansi primer yang tinggi pada penderita TB paru pada fasilitas pelayanan kesehatan di Kota Medan sehingga perlu kewaspadaan dan berbagai upaya untuk mengatasi kasus resistansi primer.Cases ofresistancebecomesa problem for thepreventionandcontrol of tuberculosis(TB) inthe world.Cases admittedtohospitalscomes mostly fromhealth care facilitiesYet the incidence of primary resistance data at health care facilities.This study aims to find out the proportion ofprimary TBresistanceto thehealth care facilitiesin Medan.This descriptive study was conductedinhealth care facilities(primary health centers andprivatephysicianpractice) fromFebruary to August2015.The subjects werepulmonary tuberculosis patientswho have nohistory ofanti-tuberculosisdrugtreatmentorhad receivedtreatmentfor less thanone month. Demographic data, chief complaint, microscopicsputum examined, radiological, cultureand data on drug sensitivitytestingbeforetherapy were collected.Out of the 31research subjectsstudiedprimary resistance were found in 3 subject (9.68%).Primary monoresistance found in 2subjects (6.45%) for isoniazid. PrimaryMDRTB foundin 1 subject (3.23%) with a combination ofdrug resistancerifampicin, isoniazidandethambutol.Conclusion:A highnumberof primaryresistancein patients withpulmonary tuberculosis inhealth care facilities in Medan. Suggest thatnecessaryprecautionsandmeasures toaddress thecases ofprimary resistance.82 HalamanTesis Magiste
The Relationship of Lung Function to The Severity of COVID-19 and Quality of Life in COVID-19 Survivors who Work at Advent Hospital Medan
No full textBackground: The high recovery rate of patients after COVID-19 infection still leaves the problem of post-COVID-19 syndrome to be addressed. Long-term negative effects on lung function and health-related quality of life have been reported after other coronavirus outbreaks, such as severe acute respiratory syndrome (SARS).
Objectives: This study aims to determine the relationship of lung function with the severity of COVID-19 and Quality of Life in COVID-19 survivors who work at Advent Hospital Medan.
Methods: This study is a cross-sectional descriptive study, where data were collected through interviews using questionnaires, quality of life questionnaires with WHOQOL-Breef and pulmonary function examinations. The study participants were COVID-19 survivors who work at Advent Hospital Medan.
Results: Of the 89 samples who met the inclusion criteria, 13 people (14.6%) experienced symptoms after COVID-19 syndrome, with the most common complaint being fatigue, as many as 10 people (11.2%). There were 21 samples with restrictive disorders, of which 16 samples (76.19%) with a mild history of COVID-19 and 5 samples (23.8%) with a history of moderate - severe COVID-19. All samples' quality of life was good.
Conclusion: There is no significant relationship between impaired lung function and the severity of COVID-19 in this study (p=0.333). There is no significant relationship between impaired quality of life and lung faeces in this study (p = 0.766).117 PagesTesis Magiste
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