1,721,230 research outputs found
Graphical chain models for the analysis of complex genetic diseases: an application to hypertension
No full textA crucial task in modern genetic medicine is the understanding of complex genetic diseases. The
main complicating features are that a combination of genetic and environmental risk factors is involved,
and the phenotype of interest may be complex. Traditional statistical techniques based on lod-scores fail
when the disease is no longer monogenic and the underlying disease transmission model is not defined.
Different kinds of association tests have been proved to be an appropriate and powerful statistical tool to detect a ‘candidate gene’ for a complex disorder. However, statistical techniques able to nvestigate direct and indirect influences among phenotypes, genotypes and environmental risk factors, are required to
analyse the association structure of complex diseases. In this paper, we propose graphical models as a
natural tool to analyse the multifactorial structure of complex genetic diseases. An application of this
model to primary hypertension data set is illustrated
Locomotory Adaptations in 3D Humerus Geometry of Xenarthra: Testing for Convergence
Full text linkThree-dimensional (3D) models of fossil bones are increasingly available, thus opening a novel frontier in the study of organismal size and shape evolution. We provide an example of how photogrammetry can be combined with Geometric Morphometrics (GMM) techniques to study patterns of morphological convergence in the mammalian group of Xenarthra. Xenarthrans are currently represented by armadillos, sloths, and anteaters. However, this clade shows an incredibly diverse array of species and ecomorphotypes in the fossil record, including gigantic ground sloths and glyptodonts. Since the humerus is a weight-bearing bone in quadrupedal mammals and its morphology correlates with locomotor behavior, it provides an ideal bone to gain insight into adaptations of fossil species. A 3D sample of humerii belonging to extant and fossil Xenarthra allowed us to identify a significant phylogenetic signal and a strong allometric component in the humerus shape. Although no rate shift in the evolution of the humerus shape was recorded for any clade, fossorial and arboreal species humerii did evolve at significantly slower and faster paces, respectively, than the rest of the Xenarthran species. Significant evidence for morphological convergence found among the fossorial species and between the two tree sloth genera explains these patterns. These results suggest that the highly specialized morphologies of digging taxa and tree sloths represent major deviations from the plesiomorphic Xenarthran body plan, evolved several times during the history of the group
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A seasonal measurements campaign of ground-based aerosol optical depth for correlation with TOMS aerosol index.
No full textA neural network to retrieve atmospheric parameters from infrared high resolution sensor spectra
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Il profilo di comunità a Palermo.
No full textIl ragionamento intorno al tema della partecipazione che qui proponiamo si intreccia con la riflessione su un particolare ambito d'azione del vivere comunitario, quello delle pratiche decisionali e di intervento partecipate, ispirate dal principio della governance. Si tratta di processi in cui attori istituzionali, insieme a cittadini e portatori d'interesse cooperano per l'individuazione e la risoluzione di problemi condivisi, all'interno di un setting di concertazione predefinito. Tali pratiche, tra cui annoveriamo il profilo di comunità, si fondano sulla possibilità e la capacità dei singoli e della comunità di reperire, attivare e mettere in circolo risorse (formali e informali) per concorrere al benessere collettivo
Processi d'interculturalità: famiglie e figli della migrazione.
No full textL'incontro tra persone di culture diverse non è certamente un fenomeno sociale nuovo; nuova piuttosto ne risulta l'entità. Le società occidentali contemporanee, infatti, ciascuna con un diverso livello di esposizione al contatto, con modalità differenti anche per natura dell'esperienza relazionale inter-gruppi, sembrerebbero procedere, seppur lentamente, verso una composizione plurietnica e multiculturale da un punto di vista pratico e simbolico-valoriale. Tra le nozioni che intervengono nell'acceso dibattito attorno all'attuale fenomeno migratorio, il tema dei processi d'interculturalità ha assunto negli ultimi decenni un peso crescente per le determinanti e la fenomenologia delle migrazioni internazionali e di pari passo con i cambiamenti socio-economici dei Paesi di accoglienza, affermandosi con insistenza negli ambiti della ricerca sociale e delle politiche pubbliche
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