1,720,986 research outputs found
Re: A Prospective Head-to-Head Comparison of 18F-Fluciclovine with 68Ga-PSMA-11 in Biochemical Recurrence of Prostate Cancer in PET/CT
No full textPET/CT And The Response To Immunotherapy In Lung Cancer
No full textIn the recent years, the introduction of immune checkpoint inhibitors has significantly changed the outcome of patients affected by lung cancer and cutaneous melanoma. Although the clinical advantages, the selection of patients and the evaluation of response to immunotherapy remain unclear. The immune-related Response Evaluation Criteria in Solid Tumor (irRECIST) was proposed as an update of the RECIST criteria for the assessment of response to immunotherapy. However, morphological images cannot predict the early response to therapy that represents a challenge in clinical practice. 18F-FDG PET/CT before and after immunotherapy has an indeterminate role, demonstrating ambiguous results due to inflammatory effects secondary to the activation of immune system. The aim of the present review was to analyze the role of PET/CT as a guide for immunotherapy, by analyzing the current status and future perspectives
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Electrochemotherapy for Superficially Metastatic Melanoma
No full textCutaneous metastases are not unusual in the clinical course of malignant melanoma, occurring in 2–20 % of patients, depending on primary tumor features and disease stage. Patients with superficially metastatic melanoma comprise a heterogeneous group as to prognosis, including those with local recurrences, satellite nodules, and in-transit metastases (stages IIIB and IIIC), as well as those with distant skin, subcutaneous, and soft tissue metastases (stage IV-M1a disease). Patients with superficially metastatic melanoma have peculiar supportive care needs due to increased psychosocial distress and wound care. Local treatment with electrochemotherapy (ECT) has been introduced in the management of melanoma since the 1990s. In these early clinical experiences, ECT showed sustained antitumor activity and favorable toxicity profile. In 2006, the procedure was standardized, and the European Standard Operating Procedure of electrochemotherapy (ESOPE) entered the routine practice of dermato-oncology. More recent experiences confirm ECT as a valuable tool that ensures prolonged local control (2-year local progression-free survival estimated 74–87 %), particularly in patients with locoregional disease and few, small tumor nodules. Unfortunately, the majority of patients require further ECT cycles due to disease progression outside treatment field. As a consequence, treatment intent can range from curative to merely palliative. To overcome this hurdle, researchers are actively investigating the way to implement electroporation technology as well as to rationally combine local ECT treatment with newly available immune (anti-CTLA4 [cytotoxic T-lymphocyte-associated antigen 4], anti-PD1 [programmed death-1]), or targeted (BRAF and MEK inhibitors) therapies, which have greatly improved patient survival during the past few years. In the meantime, it is advisable that clinicians recognize that the occurrence of skin metastases represents a troubling circumstance that requires immediate and focused attention. Before undergoing ECT, each patient should be managed by a multidisciplinary team, and its members should take into consideration the disparity in clinical course between patients with locoregional (in whom ECT intent can be curative) and distant metastases (in whom treatment intent is mainly palliative). Quality trial evidence is needed to clarify the impact of this innovative treatment for melanoma patients
Role of radiomic analysis of [18F]fluoromethylcholine PET/CT in predicting biochemical recurrence in a cohort of intermediate and high risk prostate cancer patients at initial staging
Full text linkAimTo study the feasibility of radiomic analysis of baseline [F-18]fluoromethylcholine positron emission tomography/computed tomography (PET/CT) for the prediction of biochemical recurrence (BCR) in a cohort of intermediate and high-risk prostate cancer (PCa) patients.Material and methodsSeventy-four patients were prospectively collected. We analyzed three prostate gland (PG) segmentations (i.e., PG(whole): whole PG; PG(41%): prostate having standardized uptake value - SUV > 0.41*SUVmax; PG(2.5): prostate having SUV > 2.5) together with three SUV discretization steps (i.e., 0.2, 0.4, and 0.6). For each segmentation/discretization step, we trained a logistic regression model to predict BCR using radiomic and/or clinical features.ResultsThe median baseline prostate-specific antigen was 11 ng/mL, the Gleason score was > 7 for 54% of patients, and the clinical stage was T1/T2 for 89% and T3 for 9% of patients. The baseline clinical model achieved an area under the receiver operating characteristic curve (AUC) of 0.73. Performances improved when clinical data were combined with radiomic features, in particular for PG(2.5) and 0.4 discretization, for which the median test AUC was 0.78.ConclusionRadiomics reinforces clinical parameters in predicting BCR in intermediate and high-risk PCa patients. These first data strongly encourage further investigations on the use of radiomic analysis to identify patients at risk of BCR
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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