1,721,035 research outputs found
Method for synthesis and screening of large groups of molecular imprinted polymers
No full textA technique for the synthesis of molecularly imprinted polymers (MIPs) in small scale (∼55 mg) coupled with direct in situ processing and batch rebinding evaluation is reported. The primary assessment is based on quantification by HPLC or UV absorbance measurement of the amount of template released from the polymer in a given solvent. This method allows a rapid screening of the parameters of importance to reach a desired level of binding affinity capacity and selectivity for a given target molecule. This was demonstrated for the triazine herbicide terbutylazine, where an initial screening was performed for the type of functional monomer used in the MIP preparation. Thus among the six functional monomers tested, methyl methacrylate, 4-vinylpyridine, and N-vinyl-α-pyrrolidone led to rapid and quantitative extraction whereas methacrylic acid and (trifluoromethyl)acrylic acid led to polymers that retained the template the most. After having established useful functional monomers, a secondary screening for selectivity was performed. In this, nonimprinted blank polymers were prepared and a normal batch rebinding evaluation was performed. The polymer showing the highest selectivity was the one prepared using methacrylic acid as functional monomer. This polymer was shown to strongly retain chlorotriazines including atrazine when a normal-scale batch of the polymer was evaluated in chromatography
Approaches to imprinted stationary phases for affinity capillary electrochromatography. REVIEW ARTICLE
No full textThis review article describes different techniques to prepare MIP-based chiral stationary phases specifically designed for capillary electrochromatography, to separate drug enantiomers (e.g. propranolol).
In questa review si passano in rassegna le diverse tecniche di sintesi e di impaccamento per coniugare l’impiego dei MIPs come fasi stazionarie, spesso chirali, e l’ elettrocromatografia capillare (CEC), con l’intento di valutare limiti e benefici di una tecnica recente e ancora in via di sviluppo. I diversi formati vengono descritti unitamente ad alcuni esempi di riconoscimento, soprattutto enantioselettivo, di principi attivi di interesse farmaceutico
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A Substructure Approach Towards Polymeric Receptors Targeting Dihydrofolate Reductase Inhibitors. II : Molecularly Imprinted Polymers against Z-L-Glutamic Acid Showing Affinity for Larger Molecules
No full textSynthesis and characterisation of a new MIP for the selective HPLC analysis of model oxyanions and methotrexate. Innovative approach of substructure and stoichiometric imprinting.
Sintesi di un nuovo polimero specifico e applicazione quale fase stazionaria cromatografica per l’ analisi qualitativa cromatografica (riconoscimento altamente specifico) di ossianioni modello e di metotrexato. Metodo innovativo del substructure imprinting e dello stoichiometric imprinting
Novel molecularly imprinted polymers targeting dihydrofolate reductase inhibitors: a substructure approach
No full textSurface initiated molecularly imprinted polymer films: a new approach in chiral capillary electrochromatography
No full textThis pioneering work presents for the first time the design and characterisation of novel “composite particles” based on silica and molecularly imprinted polymers, to be used as selective stationary phases in capillary electrochromatography. Efficiency, enantioselectivity and analysis times are by far superior to the HPLC counterpart. This material constitutes a new generation of MIPs for the enantioselective recognition of chiral drugs.
Questo lavoro pionieristico presenta per la prima volta la realizzazione e la caratterizzazione di nuove “particelle composite” silice-MIP come fasi stazionarie in elettrocromatografia capillare. Il sistema così messo a punto è superiore alla cromatografia classica in termini di efficienza, enantioselettività, e tempi di analisi. Questo materiale costituisce una nuova generazione di MIPs, preparati per l’analisi di molecole chirali di interesse farmaceutico
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