1,721,118 research outputs found
Polimorfismo recettoriale KIR e HHV8 nelle lesioni angioproliferative cutanee: studio osservazionale di prevalenza.
No full textGli angiomi rubino sono neoformazioni benigne, legate ad un fenomeno
di proliferazione cutanea vascolare. Nello sviluppo di tali lesioni sembra
essere coinvolto HHV8 (Human Herpes Virus 8), capace di indurre neoangiogenesi
nelle cellule endoteliali. Un ruolo importante nella suscettibilità
a tale infezione, tuttavia, è anche svolto dalla competenza immunitaria del
soggetto. La funzione di difesa è mediata dalle cellule natural killer (NK),
attraverso un sistema di segnalazione cellulare, modulato da un particolare
tipo di recettore, il KIR (killer-cell immunoglobulin-like receptor). Un
determinato aplotipo recettoriale potrebbe alterare la risposta immunitaria
promossa dalle cellule NK favorendo l’infezione di natura herpetica ed il
conseguente sviluppo di angiomi rubino. Col presente studio osservazionale,
effettuato su 60 soggetti, si è cercato di mettere in luce un possibile
legame tra aplotipo KIR, HHV8 e lesioni angioproliferative
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Patch test reactions through the lens of dermoscopy: Further insights, particularly on weak allergic reactions
No full textBackground: Distinguishing weak allergic reactions from irritant patch test reactions may be difficult. Objectives: To describe the dermoscopic features of allergic reactions (especially weak allergic ones) and irritant patch test reactions, and to assess the suitability of dermoscopy in supporting differential diagnosis. Methods: Eligible participants for this observational, cross-sectional study included consecutive adult outpatients patch tested during a 12-month period, who developed any skin reaction. Healthy volunteers were patch tested with sodium lauryl sulfate as irritant controls. At the 72-hour reading, patch test reactions were recorded both with a digital camera and a digital dermoscopic system. For each reaction, clinical and dermoscopic variables were separately assessed, scored, and then compared. Results: Erythema, vessels, and vesiculation were constant dermoscopic features of allergic reactions (n = 173). In 46 weak (+) allergic reactions, dermoscopy showed (a) erythema (100%), (b) dense polymorphic vessels (100%), and (c) whitish vesicles (78.3%). Scores for vesicles and dotted vessels were significantly higher in weak allergic than in irritant reactions. Vesicles were identified as the chief dermoscopic parameter for correctly distinguishing weak allergic from irritant reactions. Conclusions: Dermoscopy can improve accuracy in the differential diagnosis between weak allergic and irritant patch test reactions
Socioeconomic status and skin cancer incidence: a population-based, cohort study in the province of Ferrara, northern Italy
No full textTo assess the impact of socioeconomic status (SES) on the occurrence of skin cancer in the population living in the province of Ferrara, Italy, a retrospective cohort of patients with squamous cell carcinoma (SCC), basal cell carcinoma (BCC) or malignant melanoma (MM), provided by the local cancer registry, was investigated. The SES was expressed through an ecological-based deprivation index. During the 8-year study period (2006–2013, total person-years 2 859 137), 6051 carcinomas (1535 SCCs, 4365 BCCs) and 459 MMs were diagnosed. Both crude and standardized (on the European population) rates and the standardized incidence ratio showed a direct correlation between BCC and SES. Multivariate analysis confirmed these results for BCC and also for MM, while it showed an excess of SCC incidence in the lowest SES subgroup. This study shows, for the first time, to our knowledge, opposite effects of SES on SCC and BCC occurrence. A role of environmental factors conditioned by SES may be hypothesized
Pioderma gangrenoso paradosso da Abatacept.
No full textIl pioderma gangrenoso è una rara dermatosi neutrofilica non infettiva
che colpisce solitamente gli arti inferiori. Si presenta più comunemente
con pustole sterili che evolvono in ulcerazioni dolorose con bordi sottominati
eritemato-violacei. È spesso associato a malattie autoimmuni e
può insorgere secondariamente all’utilizzo di farmaci. Una donna di 68
anni affetta da artrite reumatoide long standing (non responsiva a molteplici
terapie convenzionali e biologiche) sviluppava, in corso di terapia
con Abatacept, elementi eritemato-nodulari a livello delle gambe che
andavano incontro a rapida ulcerazione; la diagnosi istologica deponeva
per pioderma gangrenoso. Si instaurava, pertanto, terapia steroidea sistemica
con progressivo miglioramento del quadro cutaneo e si sospendeva
Abatacept, sospettando suo eventuale ruolo eziologico. Abatacept è una
proteina di fusione costituita dalla porzione Fc modificata di IgG1 e dal
dominio extracellulare di CTLA-4; si lega a CD80/86, espresse su APC,
inattivando la via di costimolazione mediata dell’interazione tra il recettore
CD28 (espresso sui linfociti T) e le molecole CD80/86. L’insorgenza
del pioderma gangrenoso (ritenuta patologia autoinfiammatoria), durante
terapia con Abatacept, si configura come effetto paradosso in considerazione
dell’azione immunoregolatrice del farmaco. La patogenesi di tale
nesso causale resta ignota; non sono ancora noti i pathway immunologici
coinvolti
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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