1,720,991 research outputs found
Association between up-regulated expression proteins and circulating steroidal hormones in leiomyoma
No full textSeveral studies have shown that both ovarian hormones estrogen and progesterone and various proteins are involved in uterine leiomyoma growth. We hereby describe a study carried out to investigate the possible relation between progesterone, estrone, 17β-estradiol and the seven dysregulated proteins in the leiomyoma. Statistical analyses showed a significant inverse rank correlation between desmin expressed in leiomyoma and progesterone (ρ = −0.9276; p = 0.0077) and between alpha-1-antitrypsin expressed in leiomyoma and 17β-estradiol (ρ = −0.8571; p = 0.0137). Our data suggest that decreased levels of 17-β-estradiol involve an increasing of the inflammation response stimulating alpha-1-antitrypsin expression in leiomyoma and that lower levels of progesterone associated with increasing of desmin expression may be related to increase of inflammation response, and to the role played by desmin in signal transduction inducing leiomyoma growth
Re: Management of women with low-grade cytology: How reassuring is a normal colposcopy examination?
Full text linkThe debate over best management of low-grade smear results is still open. The Italian Society of Colposcopy and Cervico-Vaginal Pathology, in the Guidelines on the Management of Women with Abnormal Cervical Cytology stated that women with low-grade cytological abnormalities should be immediately referred for colposcopic examination in an outpatient clinic.This option was criticised because it may lead to overtreatment, complications and later adverse effects in young women, without clear psychological benefit. One suggestion that we could make is to restrict the use of a see-and-treat approach since the two-step approach, requiring a colposcopically obtained direct biopsy, as recently recommended by the Society of Obstetricians and Gynecologists of Canada, is, in our opinion, preferable and favours a better training for colposcopist
Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration
No full textUterine leiomyomas are monoclonal tumors. Several factors are involved in the neoplastic transformation of the myometrium. In our study we focused on dysregulated cytoskeletal proteins in the leiomyoma as compared to the myometrium. Paired tissue samples of ten leiomyomas and adjacent myometria were obtained and analyzed by two‐dimensional gel electrophoresis (2-DE). Mass spectrometry was used for protein identification, and western blotting for 2-DE data validation. The values of ten cytoskeletal proteins were found to be significantly different: eight proteins were upregulated in the leiomyoma and two proteins were downregulated. Three of the upregulated proteins (myosin regulatory light polypeptide 9, four and a half LIM domains protein 1 and LIM and SH3 domain protein 1) are involved in cell migration, while downregulated protein transgelin is involved in replicative senescence. Myosin regulatory light polypeptide 9 (MYL9) was further validated by western blotting because it is considered to be a cell migration marker in several cancers and could play a key role in leiomyoma development. Our data demonstrate significant alterations in the expression of cytoskeletal proteins involved in leiomyoma growth. A better understanding of the involvement of cytoskeletal proteins in leiomyoma pathogenesis may contribute to the identification of new therapeutic targets and the development of new pharmacological approaches
Violence and Women's Psychological Distress After Birth: An Exploratory Study in Italy
No full textOur aim in conducting this study was to analyze the relationships between violence and maternal psychological distress 8 months after a birth, taking into account other important psychosocial factors, known to be associated both with violence and with new mothers' mental health. A total of 352 women responded to a questionnaire after the birth at a maternity hospital in northern Italy, and 292 also participated in a telephone interview 8 months later. We evaluated psychological distress with the General Health Questionnaire (GHQ), and partner and family violence with a 28-item scale. Eight months postpartum, 5% of women showed high psychological distress; 10% were currently experiencing violence from the partner or another family member. After adjustment for covariates, the odds ratio for depressive symptoms was 13.74 for women experiencing violence. We believe that these results provide support for the important role of violence in postpartum maternal psychological distress
Hysteroscopic chasing for endometrial cancer in a low-risk population: risks of overinvestigation
No full textPURPOSE:To evaluate the appropriateness of the indications for hysteroscopy done, in fertile and postmenopausal women, for the detection of endometrial cancer.
METHODS: A retrospective analysis of 2673 consecutive women who underwent office hysteroscopy chasing for endometrial cancer between January 2012 and June 2014. According to their medical history only low-risk women entered the study.
RESULTS: A total of 1070 patients entered the study. The main outcome measure was the appropriateness of the indications for hysteroscopy. Appropriateness was assessed on the basis of guidelines of scientific societies and histologic report. According to the algorithm developed for appropriateness, 44 % of procedures resulted in being inappropriate. In reproductive-aged women 57 % of hysteroscopies were inappropriate. In postmenopausal women inappropriate hysteroscopies were 45 %. In reproductive-aged women, the reasons for inappropriateness were: absence of abnormal uterine bleeding (AUB) or AUB without a trial of progestin therapy. In postmenopausal women, the reasons for inappropriateness were: ultrasound report of endometrial thickening or polyp without bleeding.
CONCLUSIONS: Hysteroscopy is often recommended for inappropriate indications. More evidence is needed to identify the risks of overinvestigation, overdiagnosis, and related overtreatment and to better identify the threshold beyond which benefits are likely to outweigh harms
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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