1,721,003 research outputs found

    L’immagine è la realtà: tra spettri e morti viventi

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    Image is Reality: between Spectres and living Dead This paper investigates the concept of image and imagination. It starts with Bergson’s theories of image in “Matter and memory” that invoke a new epistemic idea according to which the image is not more a copy of reality, but reality itself. This “philosophy of image” allow rethinking the knowledge process as impersonal, released from the concept of subjectivity. Through the analysis of Blanchot we can observe how the image is similar to deads, or better, to living deads. The image, floating between what is alive and what is dead, makes trembling any separation between the effective and not-effective, being and not-being, the virtual and the actual. Lastly for these reasons we have to rethink it

    «VOIR PLUS QU’ON NE VOIT»: FILOSOFIA DELL’IMMAGINE O IMMAGINE DELLA FILOSOFIA?

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    This article investigates Maurice Merleau-Ponty’s concept of vision and his philosophical link with the painting of the artist Paul Cézanne. Through the works “Cézanne’s Doubt” and "Eye and Mind", this article shows that this link is not occasional, but it assumes an important philosophical role. Cézanne’s painting could be described using crucial concepts of both phenomenological project and method of Merleau-Ponty, this is the case, for instance of concepts like chiasme and expression. Along this article we could see the concept of vision switching into the meaning of "profondeur". A different meaning which emerges, according to the French philosopher, observing Cézanne works. The vision of both the artist and the philosopher is deeper than the vision that others could have. This is why the very vision is a remains of the invisibility which is to the heart of visibility. Therefore the art experience is a good example of the embodied experience, of the vision that could not be transparent but always chained

    Fare Terra. Istituzione ed espressione in Maurice Merleau-Ponty

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    In this article, we aim to focus on the notion of Earth in Merleau-Ponty’s reflections on the concept of nature and his reinterpretation of the Husserlian Umsturz. In doing so, we will use the expression “Earth-making” to describe a particular instituting dynamic, where by the term “institution” we wish to refer to the Husserlian concept of Stiftung and its original reworking by Merleau-Ponty during his 1954-55 course at the Collège de France: L’institution - La Passivité. We will therefore identify the concept of institution as a privileged way to describe our relationship with the Earth, understood as Boden [soil], envisaging in the instituting dynamic as something close to art. Finally, we will try to illustrate what Merleau-Ponty means by transcendental geology, namely the capacity to grasp the original relationship between space and time and a new way of conceptualizing the Earth as aIn this article, we aim to focus on the notion of Earth in Merleau-Ponty’s reflections on the concept of nature and his reinterpretation of the Husserlian Umsturz. In doing so, we will use the expression “Earth-making” to describe a particular instituting dynamic, where by the term “institution” we wish to refer to the Husserlian concept of Stiftung and its original reworking by Merleau-Ponty during his 1954-55 course at the Collège de France: L’institution - La Passivité. We will therefore identify the concept of institution as a privileged way to describe our relationship with the Earth, understood as Boden [soil], envisaging in the instituting dynamic as something close to art. Finally, we will try to illustrate what Merleau-Ponty means by transcendental geology, namely the capacity to grasp the original relationship between space and time and a new way of conceptualizing the Earth as

    Filosofare alla fine dei tempi. Riflessioni agambeniane

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    This work focuses on the apocalyptic nature of Giorgio Agamben's philosophical works. The dialogue with Agamben is full of references to St. Paul's letters, Kafka's literary works and Benjamin's messianism. This work tries to define the criteria of the kairological time, considered as a section of the chronological time which deactivates the discretionary mechanism, along the same lines as St. Paul's lessons, which reformulate the distinction between Jews / non-Jews. In this diacritic strategy lies the secret of any future philosophy, that is profanation, meant as the abolition of any sacred limit and the return to a human use

    QUEL CHE RESTA DELLA PSICANALISI. UNA LETTURA MERLEAU‐PONTIANA DI FREUD

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    This paper investigates Maurice Merleau‐Ponty’s interest about Freud’s philosophical works. It invokes the Freud’s recognition as “Master of the School of suspicion”, a famous definition made by Paul Ricœur. According to Ricœur, Freud’s theories take place within the philosophical stream that looks at “constituted cogito” with deep mistrust. Through the analysis of “Phenomenology of Perception” we can observe the accusation of “pansexuality” moved by Merleau‐Ponty. However, as Merleau‐ Ponty’s philosophy develops and his view changes from “existential” to “ontological”, the relation between Freud and Merleau‐Ponty changes accordingly, until the acknowledgment of the unconscious as a prediction of the “chair”

    SU FILOSOFIA E LETTERATURA. VARIAZIONI INTORNO A MERLEAU‐PONTY E L’AUTOFICTION

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    This paper sets out from a specific literary style, autofiction, which bounds autobiographical inputs to mere fiction. It will be focused the persistent ambiguity of this narrative form, aiming to an impossible sincerity. Indeed the problem of truth is precisely the spot where philosophy and literature meet each other’s destiny, as proved by Merlau‐Ponty’s theory of expression and the use of literary style.   Since when contemporary philosophy challenged rationalistic claims coming from traditional metaphysics, literature stops to be its “ugly twin”. Since when philosophy is not charged of explaining the world anymore, but creating a version of it, literature has become increasingly influent

    Progettazione, sintesi ed attività di inibitori del Proteasoma a base peptidica

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    The ubiquitin-proteasome pathway (UPP) influences essential cellular functions including cell growt, differetiation, apoptosis, signal transduction, antigen processind and inflammatory responses. Themain proteolytic component of the ubiquitin-proteasome pathway (UPP)is the 26S proteasome, responsible for the turnover of many cellular proteins and represents an attractive target for the treatment of pathologies such as cancer, as well as inflammatory, immune and neurodegenerative diseases.Natural and synthetic proteasome inhibitors having different chemical structures and potency have been discovered.In my PhD I worked on the design, synthesis and biological activity of molecules bearing pseudopeptidiche farmacoforiche different units at the C-terminus, as potential substrates for the interaction with the catalytic enzyme threonine, can inhibit specifically and selectively multicatalytic complex.Based on the data obtained from other series of inhibitors developed in our research group, which provided interesting biological results, I have designed and prepared based molecules peptides bearing new units farmacoforiche C-terminal, represented by groups isoxazolin vinyl-ester and dichloro- naftochinonici. Another series of derivatives instead, presents the methyl ester of trans-trans-muconic which pharmacophore linked to the side chain of a lysine residue common to all pseudo-tripeptides of the series.The new compounds were tested on the enzyme isolated based on their ability to inhibit three different catalytic activities of the proteasome: some of these, such as derivatives dichloro-naftochinonici, have shown a good ability of inhibition of the site post-acidic β1 and site chyme-tryptic β5
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