1,721,027 research outputs found
Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum in parasite-host cell interactions.
No full textThrombospondin related anonymous protein (TRAP) of Plasmodium falciparum is characterized by the presence of an amino acid motif based on the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG) that is found in a growing family of proteins. The sequence WSPCSVTCG is considered to confer sulpho-galactosyl-cerebroside (sulphatide) binding properties to antistasin, TSP, CS protein and properdin. The observation that TRAP is localized both on the micronemes and on the surface of P. falciparum sporozoites would suggest a role played by TRAP, and its putative sulphated glycoconjugates binding motif, in the recognition and/or entry of hepatocytes by the sporozoite. Our results indicated that TRAP constructs, expressed in E. coli, bind to sulpho-galactosyl-cerebrosides (sulphatides) and to the surface of HepG2 cells using the conserved amino acid motif WSPCSVTCG. Antisera raised against TRAP constructs inhibited sporozoite invasion of HepG2 cells thus suggesting, thus, that TRAP may be one of the parasite-encoded molecules implicated in the sporozoite invasion of hepatocytes. Moreover, the possibility that TRAP antibodies may be relevant in malaria immunity is supported by the results obtained in a prospective study conducted in a malaria endemic area. In adolescents, the presence of TRAP antibodies, before malaria transmission, correlated positively with the control of parasite density
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Wake-Up Radio Impact in Self-Sustainability of Sensor and Actuator Wireless Nodes in Smart Home Applications
Full text linkThis work discusses the impact of Wake-Up Radio
(WuR) technology to extend the battery life on sensor and
actuator nodes in a smart home scenario. The focus is on
nodes that harvest energy from light or a temperature gradient
and implement DASH7, an open-source low-power protocol
supporting both query-response and beaconing communication
models. A prototype WuR is used, with a quiescent current less
than 1 μA and a sensitivity of -38 dBm compatible with indoor
applications. Experimental data show that integrating WuR is
not convenient in nodes that need to send a message to the
network coordinator periodically, e.g. sensor nodes
implementing beaconing communication models. On the
contrary, in request-response mode, integrating the WuR, the
average actuator current consumption reduces from 35 μA
down to 6 μA during a reference period where no data or
commands are exchanged between the network coordinator
and the node. Thanks to the WuR, we find that an average
light intensity of 150 lux throughout daytime and less than 14
min of a temperature gradient of 10°C between the hot and
cold side of a thermoelectric generator are sufficient to turn
the actuator nodes for water flooding and smart heating
control into an energetically autonomous mode
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Designing Circuits for AiMC Based On Non-Volatile Memories: A Tutorial Brief On Trade-Offs and Strategies for ADCs and DACs Co-Design
Full text linkAnalog In-Memory Computing (AiMC) based on Non-Volatile Memories (NVM) is a promising candidate to reduce latency and power consumption of neural network (NN) inference in edge-computing applications. This kind of computational accelerators allows both storing weights and performing in-situ analog computation inside the array. This tutorial explores trade-offs and strategies in the design of DACs and ADCs for this kind of systems, highlighting the strong interdependence between the two converters. Starting from an analysis of input and weights encoding techniques this tutorial will then propose a discussion aiming at exploring critical aspects that constrain the design of D-A and A-D converters drawing some co-design considerations
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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