1,720,955 research outputs found
EFFICACIA DEL CARBOSSIMETILGLUCANO NELLA REGRESSIONE DELLE ALTERAZIONI CITOLOGICHE CERVICALI DI BASSO GRADO HPV CORRELATE
Get PDFLo studio si propone di valutare l’efficacia del carbossimetil?glucano (Colpofix®) in pazienti con citologia anormale includendo pazienti che allo screening presentano citologia deponente per ASCUS-LSIL, suddivise poi in pazienti con referto citologico di ASCUS o LSIL e colposcopia negativa e pazienti con citologia anormale, colposcopia positiva ed esame istologico deponente per HPV-CIN1, le quali, avendo prospettato loro la possibilità di scelta tra trattamento fisico distruttivo e follow-up, decidono per il follow-up. Metodi. Presso l’ambulatorio di Laserchirurgia e Patologia Cervico-Vaginale dell’ Istituto di Scienze Ginecologiche , Perinatologia e Puericultura dell’Università degli Studi “La Sapienza” di Roma, sede Policlinico Umberto I , nel periodo compreso tra settembre 2007 e dicembre 2008 sono state reclutate un totale di 60 pazienti che allo screening presentavano citologia deponente per ASCUS-LSIL suddivise in due sottogruppi: pazienti con referto citologico di ASCUS o LSIL e colposcopia negativa e pazienti con citologia anormale, colposcopia positiva ed esame istologico deponente per HPV-CIN1, le quali, avendo prospettato loro la possibilità di scelta tra trattamento fisico distruttivo e follow-up, hanno deciso per il follow-up. Il trattamento prevede la somministrazione di carbossimetil?glucano gel nebulizzante in ragione di una applicazione al giorno (5 erogazioni) per 20 giorni, seguiti da 10 giorni di pausa ed un ulteriore ciclo di 20 giorni. Le pazienti sono state valutate con controllo colpo-citologico a 3, 6 e 12 mesi dalla fine della terapia. Risultati. Nel gruppo di pazienti con citologia positiva e colposcopia negativa, su un totale di 30, 10 (33%) presentavano diagnosi di ASCUS, 20 (67%) di LSIL. Al primo controllo colpo-citologico a 3 mesi 8 su 10 pazienti (80%) con diagnosi iniziale di ASCUS sono risultate negative, 7 su 20 pazienti (35%) con diagnosi iniziale di LSIL sono risultate negative; al controllo colpo-citologico a 6 mesi 10 su10 pazienti (100%) con diagnosi iniziale di ASCUS sono risultate negative, 14 su 20 pazienti (70%) con diagnosi iniziale di LSIL sono risultate negative; al controllo a 12 mesi 17 su 20 pazienti (85%) con diagnosi iniziale di LSIL sono risultate negative mentre 3 pazienti (15%) sono andate perse al follow-up. Delle 30 pazienti che presentavano allo screening citologia anormale, colposcopia positiva ed esame istologico deponente per HPV-CIN1 al primo controllo colpo-citologico a 3 mesi 6 su 30 pazienti (20%) sono risultate negative, al controllo colpo-citologico a 6 mesi 18 su 30 pazienti (60%) sono risultate negative , al controllo colpo-citologico a 12 mesi 24 su 30 pazienti (80%) sono risultate negative. La persistenza di CIN1-HPV, confermata istologicamente, è stata riscontrata in 4 su 30 pazienti (13%), per le quali è stata scelta la terapia fisico distruttiva come trattamento finale, mentre 2 su 30 pazienti (6%) sono andate perse al follow-up. Conclusioni. Il nostro studio ha evidenziato, con un follow-up semestrale di 12 mesi, in donne che hanno fatto regolare uso secondo lo schema proposto del carbissimetilbetaglucano, la totale regressione delle lesioni citologiche di LSIL, con colposcopia negativa, dell’85%, e la totale regressione delle lesioni istologiche di CIN1-HPV dell’80%, rappresentando quindi una valida alternativa al trattamento fisico distruttivo immediato e al semplice “wait and see”, in quanto provvista di una buona tollerabilità al farmaco, basso costo, alta adesione delle pazienti e netto miglioramento dell’indice di regressione delle lesioni a 12 mesi
Laser vaporization in the management of CIN
No full textTo evaluate the effectiveness of laser CO2 vaporization in high-grade cervical intraepithelial neoplasias and to assess the diagnostic reliability of cytology, colposcopy, microbiology and HPV tests in predicting recurrence in a long-term outcome. Forty-four patients affectd by high-grade cervical intraepithelial neoplasia (HG-CIN) were submitted to laser CO2 vaporization and followed-up a minimum of five years. Vaginal smears for microbiological examination were detected. HPV testing was performed by polymerase chain reaction (PCR). The average age of the patients was 19.5 years (range 15-24). The cure rate after a single treatment was 95%. Two cases (5%) revealed HG-CIN persistence after three months. The five year follow-up of all cases submitted to a second laser procedure revealed negative cytologic and colposcopic findings. A higher degree of expertise and experience from the colposcopist and long-term follow-up proves the effectiveness of laser vaporization in the management of CIN in young women. It has been suggested that HPV infection alone may not be sufficient to promote carcinogenesis and that other cofactors could be involved. Microbiological tests are important to identify and treat any inflammation which might represent a cofactor of HPV infection in the pathogenesis of cervical dysplasia. Cytocolposcopic long-term follow-up, microbiological and HPV tests can improve regression of disease.Aims: To evaluate the effectiveness of laser CO(2) vaporization in high-grade cervical intraepithelial neoplasias and to assess the diagnostic reliability of cytology, colposcopy, microbiology and HPV tests in predicting recurrence in a long-term outcome. Methods: Forty-four patients affectd by high-grade cervical intraepithelial neoplasia (HG-CIN) were submitted to laser CO(2) vaporization and followed-up a minimum of five years. Vaginal smears for microbiological examination were detected. HPV testing was performed by polymerase chain reaction (PCR). Results: The average age of the patients was 19.5 years (range 15-24). The cure rate after a single treatment was 95%. Two cases (5%) revealed HG-CIN persistence after three months. The five year follow-up of all cases submitted to a second laser procedure revealed negative cytologic and colposcopic findings. Conclusions: A higher degree of expertise and experience from the colposcopist and long-term follow-up proves the effectiveness o
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Design and Integration of Automation Systems with Manual Operation: Small and Medium Enterprises Issues
No full textToday it is more and more mandatory for all commercial companies to comply with the principles and methodologies of Industry 4.0 and to achieve the related capabilities protecting their competitiveness and taking a leading-edge position on market as regards technologies. Specifically, the whole production and sale system must achieve the fundamental characteristics of Industry 4.0 approach, but specially the manufacturing companies must also change and update their management procedures, internal organization, resource training, assets and all production process to keep safe their current business capacities. This evolution process is even more critical for Small and Medium Enterprises (SME), that traditionally tend to be conservative and to protect their way of operation, usually characterized by a low level of automation. The work presented focuses on the design and integration of a semi-automatic welding cell of train bolster in a SME which is currently realizing a project aimed to the acquisition of Industry 4.0 capabilities, with special focus on manufacturing processes. Among them, one of the most important is the production of welded-steel critical structures, that the Company supplies to prime manufacturer of railway rolling stock systems. The experience gained during the activity, the criticalities due to the integration processes and the adopted design methodologies are here described. The work has been carried out consistently with the Systems Engineering principles, starting from the requirements elicitation and analysis to the systematic approach for the design and integration activities
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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