1,721,074 research outputs found
Different significance of hyperventilation-induced electrocardiographic changes in healthy subjects and patients with coronary artery disease
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Gli “sport estremi” nel cardiopatico: un inquadramento utile a consigliare i pazienti
No full textThe term “extreme sports” includes a range of sporting activities, predominantly individual, practised
outdoors in a wild and non-competitive environment, which have in common the critical role of environmental
variables, the importance of qualitative parameters in evaluating performance, the centrality of
technological elements and the high perceived risk which, together with the spectacularity, attracts the
attention of the media, favoring its popularity. Despite their diversity, these disciplines share specific risks
and physiological and pathophysiological aspects. The average age of participants is generally higher than
that of traditional and competitive sports, and the prevalence of male subjects implies a higher likelihood
of cardiological evaluation whose path has yet to be codified like that of traditional sports. The risk of
severe injuries in these sports is not higher than that of traditional sports and non-sporting activities. In
contrast, the risk of cardiovascular events is documented only for some sports practised in the mountains,
such as mountaineering, skiing and mountain biking, and it does not appear to be higher than that of
equivalent physical activities performed at low altitudes. The diagnostic and prognostic criteria for cardiological
counseling of enthusiasts are not defined. Environmental exposure to extremes of temperature,
altitude, wind and humidity, and dehydration are typical characteristics of these activities, which should
be addressed with adequate experience, preparation and equipment to minimize the potential impact on
health. Finally, many of these activities are often conducted in “remote areas” compared to the possibility
of emergency response, which should be considered in the risk assessment of an acute cardiovascular
event. The definition of cardiovascular risk constitutes an open area of research to allow the practice of
these sports to an increasing number of participants
How to explain the reduced cardiovascular mortality in the ticagrelor arm of the PLATO trial?
No full textAntianginal effect of transdermal nitroglycerin and oral nitrates given for 24 hours a day in 2,456 patients with stable angina pectoris. The Italian Multicenter Study.
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Antihypertensive activity and duration of action of dilevalol in hypertensive patients at rest and during exercise. A comparison with captopril
No full textThe aim of this study was to compare the effect of dilevalol and captopril on blood pressure and heart rate in hypertensive subjects, both at rest and during bicycle exercise. Thirty mild hypertensive patients (24 men, 6 women), aged 34-55, were studied in a randomized, double-blind, parallel group trial. After a 3-week placebo run-in, patients were randomized to receive either dilevalol (200 mg once daily) or captopril (50 mg twice daily) for 4 weeks. Dilevalol-treated patients whose diastolic blood pressure had not decreased by more than 8 mmHg from baseline (or to less than 95 mmHg) were given 400 mg once daily for a further 2 weeks. Treatment was stopped for all other patients. Blood pressure and heart rate were measured at rest and during bicycle exercise tests 4 ("peak") and 24 hours ("trough") after dosing in the dilevalol group and 4 ("peak") and 12 hours ("trough") after dosing in the captopril group. At the end of the placebo run-in, mean resting blood pressure was 156/102 mmHg in the dilevalol group and 157/103 in the captopril group. Six patients had blood pressure normalization with captopril and 9 with dilevalol 200 mg; a further 2 patients achieved normalized blood pressure levels with dilevalol 400 m
Treating acute coronary syndromes with new antiplatelet drugs: the mortality issue with prasugrel and ticagrelor.
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