1,721,072 research outputs found
Safely Improving the in Vivo Survival of Tumor Specific Cytotoxic T Lymphocytes by Co-Transfer of IL7 Receptor Alpha Chain and icaspase9
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Immunotherapy in the Treatment of Human Solid Tumors: Basic and Translational Aspects
Full text linkThe limited substantial therapeutic progresses observed in the treatment of solid tumors require concerted efforts to combine our thorough knowledge of the tumor biology with a broader comprehension of themainmechanisms regulating antitumor immune responses. In this context, in the last decade, in parallel to the changeless therapeutic quest for targeting molecules responsible for tumor progression, we have witnessed a growing consensus on the potential strong efficacy of combined immunotherapeutic approaches. Recently, these strategies, which include cancer vaccine developments, strenuously pursued for many years, have mainly focused on breaking critical inhibitory immune checkpoint pathways (i.e., PD1/PD-Ls axes), which limit the tumor aggression by different immune cells including natural killer (NK) and T lymphocytes. The strengthening of such endogenous cytolytic effectors, complemented by favoring their migration toward tumors, and/or the infusion of cells engineered with improved function (i.e., with chimeric antigen receptors) is widely considered in additional therapeutic protocols aimed at obtaining a more durable tumor growth control. This goal may also relate to the type of the hematopoietic stem cell transplantation (HSCT) utilized, if included in the treatment of the malignancy
Generation and expansion of PRAME-specific cytotoxic T-lymphocytes for adoptive T-cell therapy of hematological malignancies.
No full textTransgenic expression of inducible caspase9 suicide gene for in vivo elimination of antigen specific cytotoxic T cells (CTLs) engineered to produce cytokines.
No full textPolyclonal PRAME-Specific Cytotoxic T Lymphocytes Generated Using Protein-Spanning Pools of Overlapping Pentadecapeptides Target Chronic Myeloid Leukemia
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Preferentially expressed antigen of melanoma (PRAME)-specific cytotoxic T-Lymphocytes (CTLs) and transgenic T cells to target chronic myelogenous leukemia (CML)
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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