170,326 research outputs found
De Filippis D., Esposito G, Savani C, Scuderi C, D’Amico A, Di Marzo V, Steardo L, Teresa Iuvone.
No full text
Survival of Lactobacillus johnsonii La1 and influence of its addition in retail-manufactured ice cream produced with different sugar and fat concentrations
No full textAfter several studies have proved the benefits deriving from the ingestion of probiotic bacteria, various dairy products containing lactobacilli and bifidobacteria cultures have been formulated in recent years. A 2(4) full factorial experimental design was applied to verify the effects of Lactobacillus johnsonii La1 addition in retail-manufactured ice cream stored at two different freezing temperatures and containing two different levels of sugar and fat. Both fresh and frozen-thawed La1 cells underwent preliminary resistance tests to bile, antibiotics, SDS, and acidity. La1 strain proved to be highly resistant to most of stress factors, thus excluding the possibility to find evidence of cell sublethal injuries caused by freezing. When the microorganism was added to ice cream mixes in the quantity of 10(7) cfu g(-1), it did not modify the overrun and firmness of the finished product. Regardless of formulation, no count decay of La1 cells was observed in ice cream stored for up to 8 months
Cour de justice des Communautés Européennes (6e ch.), 25 juin 1997. Procédures pénales contre Euro Tombesi et Adino Tombesi (C-304/94), Roberto Santella (C-330/94), Giovanni Muzi e.a. (C-342/94) et Anselmo Savani (C-224/95). Déchets - Notion - Directives n°91/156/CEE et 91/689/CEE du Conseil - Règlement (CEE) n° 259/93 du Conseil
No full textCour de justice des Communautés Européennes (6e ch.), 25 juin 1997. Procédures pénales contre Euro Tombesi et Adino Tombesi (C-304/94), Roberto Santella (C-330/94), Giovanni Muzi e.a. (C-342/94) et Anselmo Savani (C-224/95). Déchets - Notion - Directives n°91/156/CEE et 91/689/CEE du Conseil - Règlement (CEE) n° 259/93 du Conseil. In: Revue Européenne de Droit de l'Environnement, n°1, 1998. pp. 69-77
Cour de justice des Communautés Européennes (6e ch.), 25 juin 1997. Procédures pénales contre Euro Tombesi et Adino Tombesi (C-304/94), Roberto Santella (C-330/94), Giovanni Muzi e.a. (C-342/94) et Anselmo Savani (C-224/95). Déchets - Notion - Directives n°91/156/CEE et 91/689/CEE du Conseil - Règlement (CEE) n° 259/93 du Conseil
No full textCour de justice des Communautés Européennes (6e ch.), 25 juin 1997. Procédures pénales contre Euro Tombesi et Adino Tombesi (C-304/94), Roberto Santella (C-330/94), Giovanni Muzi e.a. (C-342/94) et Anselmo Savani (C-224/95). Déchets - Notion - Directives n°91/156/CEE et 91/689/CEE du Conseil - Règlement (CEE) n° 259/93 du Conseil. In: Revue Européenne de Droit de l'Environnement, n°1, 1998. pp. 69-77
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
CB1 receptor selective activation inhibits β-amyloid-induced Inos protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons
No full textAmong the wide range of neuro-inflammatory signalling molecules released by beta-amyloid-stimulated astroglial cells, nitric oxide (NO) plays a fundamental role in AD aethiopathogenesis since it directly promotes neuronal tau protein hyperphosphorylation leading to neurofibrillary tangle formation. Synthetic cannabinoids (CBs), via a selective CBI receptor activation, negatively modulates both iNOS protein expression and NO production induced by pro-inflammatory stimuli. In this study we investigated the role of both the non-selective WIN 55,212-2 and the selective CB I receptor agonist, ACEA, on: (i) NO production, (ii) iNOS protein expression in (1-42) beta-amyloid peptide (A beta)-stimulated C6 rat glioma cells and (iii) tau protein hyperphosphorylation in co-cultured differentiated PC 12 neurons. Our results demonstrated that synthetic CBs, by a selective CB 1 effect, down-regulate iNOS protein expression and NO production in A beta-stimulated C6 cells. This effect leads, in turn, to a significant and concentration-dependent inhibition of NO-dependent tau protein hyperphosphorylation in co-cultured PC 12 neurons. The results of the present study extend our knowledge about the neuroprotective actions of synthetic CBs on A beta-dependent neurotoxicity in vitro. Furthermore, our study allows us to identify, in the CB 1-mediated inhibition of astroglial-derived NO, a new potential target to blunt tau hyperphosphorylation and the consequent related tauopathy in AD. (c) 2006 Elsevier Ireland Ltd. All rights reserved
CB1 RECEPTOR SELECTIVE ACTIVATION INHIBITS BETA AMYLOID-INDUCED INOS PROTEIN EXPRESSION IN C6 CELLS AND SUBSEQUENTLY BLUNTS TAU PROTEIN HYPERPHOSPHORYLATION IN CO-CULTURED NEURONS
No full textMitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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