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Epilepsy in definite multiple sclerosis (MS): comparison of two hospitalisation-based series in Sardinia
No full textEpilepsy in definite multiple sclerosis (MS): comparison of two hospitalisation-based series in Sardinia
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Reduced intravenous glutathione in the treatment of early Parkinson's disease
No full text1. Several studies have demonstrated a deficiency in reduced glutathione (GSH) in the nigra of patients with Parkinson's Disease (PD). In particular, the magnitude of reduction in GSH seems to parallel the severity of the disease. This finding may indicate a means by which the nigra cells could be therapeutically supported. 2. The authors studied the effects of GSH in nine patients with early, untreated PD. GSH was administered intravenous, 600 mg twice daily, for 30 days, in an open label fashion. Then, the drug was discontinued and a follow-up examination carried-out at 1-month interval for 2-4 months. Thereafter, the patients were treated with carbidopa-levodopa. 3. The clinical disability was assessed by using two different rating scale and the Webster Step-Second Test at baseline and at 1-month interval for 4-6 months. All patients improved significantly after GSH therapy, with a 42% decline in disability. Once GSH was stopped the therapeutic effect lasted for 2-4 months. 4. Our data indicate that in untreated PD patients GSH has symptomatic efficacy and possibly retards the progression of the disease
Alpha b-crystallin-reactive T-cell lines in Sardinian multiple sclerosis and healthy controls
No full textEvidence of early childhood as the susceptibility period in multiple sclerosis: space-time cluster analysis in a Sardinian population
No full textThe authors analyzed the natural history of multiple sclerosis (MS) before onset to identify the period of susceptibility
and exogenous factors that might play a role in causing the disease. Space-time cluster analysis was
performed among northern Sardinians, a genetically stable Italian population that showed an increasing risk of MS
between 1965 and 1999. Residence changes from birth to clinical onset were recorded for all MS patients with
clinical onset between 1965 and 1999 in the province of Sassari. Closeness in space and time was defined as living
in the same municipality and differing in year of birth by 1, 2, or 5 years. Analyses were performed for the period
from birth to age 25 years or MS onset and in demographic and clinical subgroups. Clustering was substantial in
early childhood. Clustering was most marked in the most recent cases, among women, and among patients with
early age at onset, a relapsing-remitting course, and in the eastern subarea. No clustering was found when
closeness in time was defined as a fixed number of years before onset, which argues against a fixed latency
period. Early childhood seemed to be a period of increased susceptibility to MS. This evidence and the increasing
incidence of MS in northern Sardinia are compatible with a change in environmental exposure
Evidence of early childhood as the susceptibility period in multiple sclerosis. Space-time cluster analysis in a Sardinian population
No full textThe authors analyzed the natural history of multiple sclerosis (MS) before onset to identify the period of susceptibility and exogenous factors that might play a role in causing the disease. Space-time cluster analysis was performed among northern Sardinians, a genetically stable Italian population that showed an increasing risk of MS between 1965 and 1999. Residence changes from birth to clinical onset were recorded for all MS patients with clinical onset between 1965 and 1999 in the province of Sassari. Closeness in space and time was defined as living in the same municipality and differing in year of birth by 1, 2, or 5 years. Analyses were performed for the period from birth to age 25 years or MS onset and in demographic and clinical subgroups. Clustering was substantial in early childhood. Clustering was most marked in the most recent cases, among women, and among patients with early age at onset, a relapsing-remitting course, and in the eastern subarea. No clustering was found wh..
Depression, quality of life and disability in Sardinian patients suffering from multiple sclerosis (MS)
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