1,720,960 research outputs found
Progesterone preconditioning increases regenerative and immunomodulatory properties of amniotic epithelial cells in experimental model of Achilles tendon lesion
No full textPlacenta Stem Cells from Domestic Animals: Translational Potential and Clinical Relevance
Full text linkThe field of regenerative medicine is moving toward clinical practice in veterinary science. In this context, placenta-derived
stem cells isolated from domestic animals have covered a dual role, acting both as therapies for patients and as valuable cell
source on translational models. The biological properties of placenta-derived cells, comparable among mammals, make them
attractive candidates for therapeutic approaches. In particular, stemness features, low immunogenicity, immunomodulatory
activity, multilineage plasticity, and their successful capacity of long-term engrafting in different host tissues after autotransplantation,
allo-transplantation, or xenotransplantation have been demonstrated. Their beneficial regenerative effects in
domestic animals have been proven using preclinical studies as well as clinical trials starting to define the mechanisms involved.
This is, in particular, for amniotic-derived cells that have been thoroughly studied to date. The regenerative role arises from a
mutual tissue-specific cell differentiation and from the paracrine secretion of bioactive molecules that ultimately drive crucial
repairing processes in host tissues (e.g., anti-inflammatory, antifibrotic, angiogenic, and neurogenic factors). The knowledge
acquired so far on the mechanisms of placenta-derived stem cells in animal models start to represent the proof of concept of
their successful use in some therapeutic treatments such as the musculoskeletal disorders. In the next future, legislation in
veterinary regenerative medicine will be a key element in order to certify those placenta-derived cell-based protocols that
have already demonstrated their safety and efficacy using rigorous approaches and to improve the degree of standardization of
cell-based treatments among veterinary clinicians
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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