1,721,038 research outputs found
A comprehensive on-line digestion-liquid chromatography/mass spectrometry/collision-induced dissociation mass spectrometry approach for the characterization of human fibrinogen.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Low protein Z levels and risk of occurrence of deep vein thrombosis
No full textBackground Protein Z (PZ) serves as a cofactor for activated FX inhibition by protein Z-dependent protease inhibitor. In vivo and in vitro studies aimed at investigating the role of PZ levels in venous thrombosis produced conflicting results.
Objectives We have investigated whether reduced PZ levels and PZ gene common variants are associated with deep venous thrombosis.
Patients/Methods In 197 patients with deep vein thrombosis and in 197 age- and sex-matched controls, PZ plasma levels and gene polymorphisms were evaluated by means of an enzyme-linked immunosorbant assay and direct cycle sequence analysis.
Results Similar PZ levels were found in controls (1.44+0.63 μg/ml) and in patients (1.44+0.96 μg/ml). The prevalence of PZ levels below the 5.0 (0.52 μg/ml) or the 2.5 percentile of controls (0.47 μg/ml) was higher in patients (10.2 % and 8.7%, respectively) than in controls (4.1%; OR: 2.7 [95% C.I.: 1.2-7.3] and 2.0%; OR: 4.6 [95% C.I.: 1.5-13.9], respectively). This relationship was independent of the effect of age, sex, and FV Leiden and FII A20210 allele (OR: 2.8, 95% C.I.: 1.1-7.3 and 4.9, 95% C.I.: 1.4-17.3). PZ levels were associated with the intron C g–42a and the intron F g79a polymorphisms in cases (R2:0.129) and in controls (R2:0.140). However, frequencies of the PZ gene polymorphisms were similar in the two groups and were not associated with PZ very low levels .
Conclusions Present data suggest an association between very low PZ plasma levels and the occurrence of deep venous thrombosis, PZ gene polymorphisms little contributing to this relationship
In the presence of other inherited or acquired high-risk situations, the Factor V Cambridge mutation may be an additional thrombophilic risk, through its effect on APC sensitivity
No full textA new case of combined factor V and factor VIII deficiency further suggests that the LMAN1 M1T mutation is a frequent cause in Italian patients.
No full textCoexistence of beta-thalassemia and hereditary hemochromatosis in homozygosity: a possible synergic effect?
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
- …
