1,721,001 research outputs found
Sassari, Il Castello riscoperto. Primi dati sui recenti ritrovamenti a Sassari in Piazza Castello
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Dieci anni di scavi
Full text linkBreve presentazione del volume dedicato a Monteleone Rocca Doria, le cui ricerche archeologiche iniziarono nel 1998. Nei testi contenuti non si parla di sequenze e stratigrafia, di datazione e contesti ceramici: il volume non vuole essere un riferimento scientifico ma nasce come una riflessione sull'archeologia di Monteleone
Archeologia e calcolatori
Full text linkQuesto articolo non vuole essere l'ennesimo e prolisso trattato sui benefici che l'informatica porta alla moderna metodologia archeologica, bensì prende in esame una situazione che oggettivamente va creandosi nelle università di tutta Italia e che diverse voci, certamente più titolate della mia, vanno denunciando da qualche anno
Relazione sulla campagna di scavo del sito di Tudera (agro di Monteleone Rocca Doria- SS), 2008.
No full textAntiproliferative activity of Verteporfin in Embryonal and Alveolar Rhabdomyosarcoma cell lines
Full text linkRhabdomyosarcoma (RMS) is a pediatric tumor, which arises from muscle precursor cells. Recently, it has been demonstrated that Hippo Pathway (Hpo) is involved in tumorigenesis of RMS. Thanks to its kinase cascade, which activates Yes-Associated Protein 1 (YAP1-YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), Hpo is able to activate several physiological and biological features. YAP and TAZ are the heart of Hpo and they showed to have both cytoplasmic and nuclear role. In the nucleus, YAP is able to bind TEAD factors and constitute a complex that activates the transcription of several genes such as MYC, Tbx5 and PAX8 or maintains the stability of others like p73.
The key role of YAP and TAZ in cancer is leading to the development of new compounds able to block their action. One of these drugs is called Verteporfin (VP). This molecule is able to stop the formation of YAP/TEAD complex in the nucleus.
Considering that RMS is an aggressive tumor and that YAP recovers an important role on it, the aim of this project was to understand if VP is able to have a specific effect on RMS cell lines.
This work showed that VP has an antiproliferative action on RMS cell lines. VP perturbs cell cycle in a different manner depending on RMS cell lines. Through its action, VP modifies also the phenotype of RMS cells. Moreover, this drug is able to induce the activation of apoptosis mechanism through the cleavage of PARP protein in RMS cell lines. Furthermore, siRNA-induced knock down of YAP clarifies that VP induces anti proliferative action through other mechanism
Alghero. Le trasformazioni di uno spazio urbano tra XIV e XX secolo. Il progetto di ricerca e le campagne di scavo 1997/1998: relazione preliminare, in “Archeologia Postmedievale”.
No full textDocumentare l’archeologia in 3 Dimensioni: problematiche e metodologie proposte
No full textThe research examines the technique and use of digital documentation for the interpretation of archaeological contexts: they were developed through the application of multi-scale three-dimensional technologies, photogrammetry and laser scanner, on two case studies.The aim was to define a method based on the integration of available sources and to create a documentation that could follow international standards, ensuring scientific transparency and authenticity of digital sources.In both cases the integration of sources, archaeological and historical, analogical and digital, has allowed a complete 3D documentation of the sites and some reconstructive hypotheses based on the interpretation of the elements emerging from the relief.Using the same digital documents, it has been possible to reconstruct the monastic complex of Salvennor, disappeared today; a 3D and gaming modelling software was used to create an attractive virtual visit to the site of Sant'Imbenia, which may interest both the researcher and the great public
Ontologie di applicazione ed informazione geografica: la ricognizione nel territorio di Siligo (Sassari)
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