1,721,077 research outputs found
Potent and Selective Activity of Daphnane Diterpens against HIV-1, HIV-2 and Coxsackievirus
No full textProgetto e costruzione della prima Carbonia. La Città giardino razionalista (1937-38)
No full textIl libro documenta un primo esito, ancora parziale, della ricerca paziente sugli archivi – in particolare quello dell’Istituto Fascista per le Case Popolari di Carbonia – condotta non per isolare prodotti di eccellenza ma per documentare un intero progetto insediativo, quello della costruzione del distretto dell’energia “autarchica” e della sua capitale, Carbonia.
La documentazione raccolta contribuisce a delineare il profilo del più grande cantiere di architettura dell’autarchia italiana degli anni ’30, nel quale la storia materiale e costruttiva più minuta e specifica si inscrive e trova motivazioni e significati a volte inediti nello sfondo dei grandi processi istituzionali e economico-politici che l’hanno generata
La seconda fase delle fondazioni (1939-1943)
No full textLa prima Carbonia è stata appena inaugurata, alla fine del 1938, che già si comincia a progettare la “grande Carbonia” per 35 e poi 50.000 abitanti, la vera e propria capitale del distretto del carbone. La prima Carbonia, come abbiamo visto, è soprattutto la città di Gustavo Pulitzer. Ma la seconda Car- bonia, seppure capitale incompiuta, è la città di Eugenio Montuori, almeno nella nuova versione della città giardino “densificata”, e nei pochi frammenti realizzati del grande “raddoppio” oltre la valle del Rio Cannas. È lui che prima gestisce sapientemente la transizione tra l’una e l’altra nel ‘39, garan- tendo la continuità, e poi progetta una per una tutte le matrici, destinate a rimanere come prototipi isolati, della nuova periferia urbana, la “Siedlung interrotta” di Carbonia
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
STRUCTURAL REARRANGEMENTS IN THE PARAMYXOVIRUS FUSION COMPLEX IN THE PRESENCE OF A NOVEL ANTIVIRAL.
No full textHuman parainfluenza virus type 3 (HPIV3), an enveloped virus representative of human paramyxoviruses, enters cells by fusing directly with the cell membrane. The viral receptor-binding glycoprotein hemagglutinin-neuraminidase (HN) binds to cellular receptors and activates the viral fusion protein (F) to its fusion-ready state; the transition of F to its final post-fusion state enables the merger of viral and cell membranes. HN is comprised of a transmembrane domain, a stalk that interacts with F, and a globular head, and is present on the infected cell as a dimer of dimers. Crystal structures show HN either with the heads flipped down partially covering the stalk, or with heads up exposing the stalk. Our previous analysis of HPIV3 particles using negative-stain electron tomography showed that prior to receptor engagement the surface of viral particles bear a continuous coat of spikes with two layers of alternating density reflecting the configuration of complexed HN and F with the globular heads of HN oriented upwards. HN and F are complexed prior to receptor binding, and the transition to a heads-up conformation does not drive the F-activation that occurs upon HN’s receptor engagement. We aim to discover how receptor engagement activates the structural changes in HN and F that lead to membrane merger and infection.
To capture intermediate states in this process, we used a small molecule receptor-mimic (CM9) that we have shown to interact with HN and thereby induce F-triggering in the absence of receptor engagement, thus inactivating the virus. We hypothesize that in the presence of this small molecule HN and F are in contact and F is converted to its post-fusion state. To this end, purified HPIV3 preparations were incubated with CM9 and the structure and arrangement of HN/F are being analyzed by negative stain electron microscopy and cryo-electron tomography. Parallel biological and biochemical experiments demonstrate that CM9 inactivates virus and inhibits viral infectivity in cell culture, ex vivo, and in animals, and that interaction of CM9 with HN results in conversion of F to protease sensitivity as an indicator of conformational transition. We expect to observe the intermediate between pre- and post-fusion F in the presence of a lipid-conjugated peptide that binds the transitional state of F, and in future studies we aim to develop this new antiviral target while identifying the key interactions between native HN and F that result in fusion activatio
Phenyl-benzotriazoles: new potent and selective inhibitors of Respiratory Syncytial Virus and Hantaviruses
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