196,174 research outputs found
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones
No full textTwo series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL). The newly synthesized pyrazolones were also computationally investigated to analyze if their properties fit the pharmacophoric model for antitubercular compounds previously built by us. The results are in agreement with those reported by us previously for a class of pyrazole analogues and confirm the fundamental role of the p-chlorophenyl moiety at C4 in the antimycobacterial activity
Synergistic interactions in vitro between Rifabutin and newly synthesized s-alkylthiosemicarbazone derivatives against M. avium
No full textUnusual clinical presentation of Mycobacterium fortuitum infection in an immunocompetent woman
No full textThe Mycobacterium fortuitum group of rapidly growing nontuberculous mycobacteria is an uncommon cause
of renal infection, particularly in otherwise healthy hosts. We describe a case of nephritis due to M. fortuitum
in an immunocompetent woman with a clinical and radiological diagnosis of renal tuberculosis
Studio di un metodo rapido mediante riduzione di XTT per la determinazione della resistenza in Mycobacterium tuberculosis
No full textAumento della sensibilità all’AmB di biofilm di Candida albicans fluconazolo-resistente nell’impiego combinato con derivati ciclici isotiosemicarbazonici
No full textIn vitro activity of 2-cyclohexylidenhydrazo-4-phenil-thiazole compared with those of amphotericin b and fluconazole against clinical isolates of Candida spp. and fluconazole-resistant Candida albicans
No full textObjectives: The aim of this study was to investigate the in vitro antifungal activity of an isothiosemicarbazone cyclic analogue against isolates of Candida spp. including fluconazole-resistant Candida albicans.
Methods: We investigated the activity of 2-cyclohexylidenhydrazo-4-phenyl-thiazole (EM-01D2) against 114 clinical isolates of Candida spp., representing five different species, by microdilution, according to the NCCLS method 27-A. The activity against C. albicans biofilms was also investigated. Toxicity in vitro was evaluated by MTT reduction assay.
Results: EM-01D2 demonstrated low toxicity, broad spectrum, fungicidal activity and was active against C. albicans and Candida krusei at concentrations lower than those shown by amphotericin B and fluconazole (P < 0.05). It maintained potent in vitro activity against fluconazole-resistant C. albicans isolates. Fungicidal activity occurred at concentrations 1–2 doubling dilutions greater than the corresponding MICs, and time–kill analysis indicated that a 99.9% loss of C. albicans viability occurred after 6 h of incubation in the presence of EM-01D2 at concentrations equal to four times the MIC. EM-01D2 was also active in inhibiting the growth of C. albicans ATCC 10231 biofilms, even though such inhibition occurred at concentrations higher than the MICs determined under planktonic growth conditions. However, when C. albicans biofilms were pre-exposed to subinhibitory concentrations of EM-01D2, a reduction of MIC50 of amphotericin B was observed.
Conclusions: Based on these results, EM-01D2 could represent a template for the development of novel fungicidal agents
Studio della attività di una nuova classe di isotiosemicarbazoni nei confronti di Aspergillus spp. di isolamento clinico.
No full textAttività di un derivato isotiosemicarbazonico ciclico nei confronti di biofilm di Candida albicans FLC-S e FLC-R in combinazione con AMB
No full textInibizione selettiva della RNA polimerasi in isolati clinici di M. tuberculosis RMP-resistenti e MDR mediante derivati dell’acido fenazin-1-carbossilico
No full textDerivati fenazinici come potenziali agenti per il trattamento delle infezioni sostenute da M. tuberculosis resistenti e multiresistenti
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