1,438 research outputs found
Telegram from Irving Flicker, with response from Eliahu Epstein, regarding the Israeli Government
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban, Jewish garment workers, many of whom had emigrated from Europe. Mayor Irving Flicker sent a telegram to the Jewish Agency for Palenstine, to congratulate the Israeli government on its recent independence, and on the recognition by the United States of Israel as an independent country. Eliahu Epstein, Representative of the Provincial Government of Israel, sent a reply telegram to Flicker, thanking him for his message and sending his regards to the Roosevelt Community. As a predominantly Jewish community, the establishment of Israel as an independent state was a significant event that connected Jersey Homestead citizens to the global Jewish community
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Does Texas Value Reliable Energy? Texas Energy Policy with Alex Epstein
No full textAlex Epstein, author of "The Moral Case for Fossil Fuels," discusses reliable energy and Texas' energy policy with Salem Center's Gregory Salmieri and Carlos Carvalho.Salem Cente
[Letter from Albert K. Epstein to Dr. Meyer Bodansky - November 20, 1930]
No full textLetter from Albert K. Epstein to Dr. Meyer Bodansky suggesting that he read a critique an author wrote on his textbook
Epstein\u27s Premises
No full textThis Article criticizes Richard Epstein\u27s argument that Congress should repeal Title VII expressed in his book Forbidden Grounds: The Case Against Employment Discrimination. The author\u27s criticisms of Epstein\u27s argument are the product of disagreement with some of Epstein\u27s premises, and disagreement with some of Epstein\u27s choices about where to stop his analyses. The author disputes Epstein\u27s premise that governmental intervention into otherwise accessible markets is justifiable only in cases of force or fraud. The author also notes some of Epstein\u27s empirical suppositions that are inconsistent with one another
Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication.
No full textEBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 and LF3. These genes themselves consist largely of 125 and 102 bp repetitive sequences, respectively, and encode basic proteins. We have examined these genomic regions in detail in attempts to understand why lytic replication—necessary for virus survival—is so inefficient, and to identify controlling elements. Our studies uncovered a diverse family of promoters (P) for BHLF1 and LF3, only one pair of which (P1) proved sensitive to chemical inducing agents. The others (P2–P3/4), abutting the replication ‘core’ origin elements in DS and extending into 50-unique sequences, may play roles in the maintenance of viral latency. We further identified a family of overlapping small complementary-strand RNAs that transverse the replication ‘core’ origin elements in a manner suggesting a role for them as ‘antisense’ species and/or DNA replication primers. Our data are discussed in terms of alternative lytic replication models. We suggest our findings might prove useful in seeking better control over viral lytic replication and devising strategies for therapy
Unconstitutional Conditions Obscured: A Brief Response to Professor Abrams
No full textIn this Article, Professor Epstein responds to Professor Abram\u27s critique of the former\u27s article on the doctrine of unconstitutional conditions. Professor Epstein organizes his response in three parts. He first addresses Professor Abram\u27s contention that Professor Epstein has not explained why the use of monopoly power by the government constitutes a situation that requires some constitutional supervision. Second, Professor Epstein answers Professor Abram\u27s claim that the former\u27s economic analysis is flawed because it requires reliance upon motivational investigations ordinarily regarded as out of bounds by economic theory. Third, Professor Epstein answers the claim that he inadequately treated the externality problem as it arises in economic theory. The author concludes by noting that Professor Abrams\u27 article, which is critical, negative, and fundamentally misguided, adds nothing to the sum of human knowledge
Russian Spirituality and the Secularization of Culture.
No full text“Mikhail Esptein is a preeminent authority on Russian spirituality, and this fine book shows why. With his characteristic erudition Epstein brings the reader to the origins of Russian intellectual tradition, showing how it continues to inform some of the most heated debates in modern Russia. According to the author, this culture occupies a unique position on the intersection of Western and Eastern spirituality, and the tension between these powerful crosscurrents creates a space for the kind of religious, artistic, and intellectual creativity we have come to associate with Russia. Epstein treats these complex, fascinating subjects with the admirable clear-headedness and discernment that make the book valuable to experts and common readers alike"
Is There An American Woman?
No full textMaxwell D. Epstein, Iowa State's Foreign Student Advisor, wrote this article for the International Newsletter, a publication which serves as a forum for news and views of cultural and international interest. The article is reprinted here with the permission of its author and the International Newsletter.</p
Conditional immortalization of human B cells by CD40 ligation
No full textIt is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro. Here we readdress this issue, studying the long-term proliferation potential of human B cells. It was shown earlier that human B cells from peripheral blood of healthy donors can be efficiently induced to proliferate for up to ten weeks in vitro by stimulating their receptor CD40 in the presence of interleukin-4. When we applied the same stimuli under conditions of modified cell number and culture size, we were surprised to find that our treatment induced B cells to proliferate throughout an observation period of presently up to 1650 days, representing more than 370 population doublings, which suggested that these B cells were immortalized in vitro. Long-term CD40-stimulated B cell cultures could be established from most healthy adult human donors. These B cells had a constant phenotype, were free from Epstein-Barr virus, and remained dependent on CD40 ligation. They had constitutive telomerase activity and stabilized telomere length. Moreover, they were susceptible to activation by Toll-like receptor 9 ligands, and could be used to expand antigen-specific cytotoxic T cells in vitro. Our results indicate that human somatic cells can evade senescence and be conditionally immortalized by external stimulation only, without a requirement for genetic manipulation or oncoviral infection. Conditionally immortalized human B cells are a new tool for immunotherapy and studies of B cell oncogenesis, activation, and function
Epstein-Barr virus latent proteins regulate expression of the anti-apoptotic cellular bfl-1 gene
No full textThe ubiquitous and oncogenic human herpes-virus Epstem-Barr virus (EB V) establishes a latent infection and promotes the long-term survival of the infected host cell by targeting the molecular machinery that controls cell fate decisions, including apoptosis, proliferation and differentiation. These host-virus interactions are likely to play a crucial role in the development of EBV-associated malignancies such, as Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma and tumours in lmmunosuppressed individuals. It has previously been shown in our laboratory that two EBV latent proteins, latent membrane protein 1 (LMP1) and EBV nuclear antigen 2 (EBNA2), which are major effectors of cellular phenotypic change, can independently regulate expression of the cellular bfl-1 gene Bfl-1 is an anti-apoptotic protein of the Bcl-2 family, whose preferential expression in hematopoietic and endothelial cells is controlled by inflammatory stimuli. In this study, it is reported that LMP1 and EBNA2 regulate bfl-1 activity through interactions with components of the NF-kB and Notch signalling pathways respectively NF-kB composed of p65 sub-units trans-activated the bfl-1 promoter m the EBV-negative cell line DG75, and an NF-icB-like binding site at position -52 to -43 relative to the transcription start site was essential for this effect. An RBP-Jk/CBF1 mutant blocked EBNA2-mediated trans-activation of bfl-1 in DG75 cells, indicating an important role for this DNA-binding protein in bfl-1 trans-activation by EBNA2. Although RBP-Jk/CBFI is also essential for signalling by the cellular equivalent of EBNA2, mtra-cellular Notch (NotchIC), this protein was not found to trans-activate the bfl-1 promoter. Both EBNA2 and LMP1 are expressed in EBVmfected cell lines, and EBNA2 is responsible for induction of LMP1 Blocking of either EBNA2- or LMP1-mediated signalling in EBV-mfected cell lines did not dramatically affect the level of bfl-1 promoter activity. However, when both EBNA2 and LMP1 signalling were blocked simultaneously, a significant decrease in the level of bfl-1 activity was observed. These data indicate a role for both EBNA2 and LMP1 in the regulation of the promoter for the bfl-1 gene m the context of the EBV-infected cell. These findings are relevant to our understanding of EBV persistence in the infected host, and its role in malignant disease
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