1,721,039 research outputs found
ROLE OF NON IMMUNE CELLS IN THE PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE
No full textInflammatory bowel diseases pathogenesis reflects an integrated activation of signaling events within and between components of the intestine including the epithelial cells, nervous system, immune cells, endothelial cells, and the extracellular matrix [16]. All intestinal resident cells are involved in IBD [12]. Many reports have demonstrated damage to the intestinal microvasculature, epithelial barrier dysfunction, autonomic nerve fiber destruction, as well as myofibroblastic transformation of smooth muscle cells, providing solid evidence for the physical and functional involvement of non immune cells in IBD pathogenesis [18-21]. The enormous complexity of IBD pathophysiology requires a systematic approach to identify the molecular events that cause and sustain inflammation. During my three years of PhD I have focused my attention mainly on the role of two types of non immune cells in the IBD pathogenesis: epithelial cells and endothelial cells. Therefore the objectives of my thesis can be summarized in two principal aims:
1. The involvement of intestinal epithelial cells in the IBD pathogenesis
2. The involvement of intestinal endothelial cells in the IBD pathogenesis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
TMJ biomechanical constraints: the disc and the retrodiscal tissue.
No full textThe temporo-mandibular-joint is a highly particular and complex anatomical entity in terms of both its structure and functions, which include the opening, closing, protrusion and lateral movement of the jaw. On the base of some papers previously published on the anatomy and physiology of the Temporo-Mandibular-Joint, the Authors have studied the functional dynamics of the TMJ. The correct postural and functional relationships between the various components of the joint are controlled by a series of biomechanical restrictions that guide and condition its movements. The role of biomechanical restriction played by such articular components, influences decidedly the therapeutical treatment aimed to the resolution of the Temporo-Mandibular joint pathology. In this article, the authors examine and analyze the role of the Temporo-Mandibular ligament, Disk Lateral Ligament, Articular disk, Retrodiskal Zone and of the Synovial Fluid in the functional dynamics of the Temporo-Mandibular-Joint
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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