517 research outputs found
Nonlinear twisted multicore fibers with PT-symmetry
No full textWe investigate linear and nonlinear modes of parity-time (PT)-symmetric multicore fibers with a twist of peripheral cores with gain and loss around
the lossless central core. We determine the spectral properties of such a light guiding system and demonstrate that the presence of the lossless central core combined with the fiber twist may significantly change the supermode structure, as well as the PT-symmetry breaking threshold of the multicore fiber with gain and loss. We also construct stationary nonlinear modes of the fiber and verify their stabilit
DNA-abzymes in autoimmune diseases in clinic and experiment
No full textDNA-abzymes enzymes in autoimmune diseases in clinic and experiment T.E. Naumova, O.M. Durova, A.G. Gabibov, Z.S. Alekberova, S. V. Suchkov DNA-hydrolyzing autoantibodies (AAB) or DNA-abzymes can be found in autoimmune diseases in clinic and experiment. Technology of serum express screening for presence of DNA abzymes is described. Comparative study of DNA-hydrolising activity in patients with different forms of systemic and organ-specific autoimmune diseases was performed. Blood of clinically healthy donors was usually free of IgG DNA-abzymes. DNA-abzymes were most often revealed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) less often in patients with organ-specific forms of autoimmune disturbances. The results of the study confirm the hypothesis of autoimmune origin of IgG DNA abzymes and demonstrate the possibility to use them in clinical practice for monitoring to disease activity in SLE and RA
How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches
No full textStem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been conclusively demonstrated. Consequently, the focus of research in the field has since shifted to stem cell-derived paracrine factors, including cytokines, growth factors, mRNA, and miRNA. Notably, both mRNA and miRNA can enter into the extracellular space either in soluble form or packed into membrane vesicles. Stem cell-derived paracrine factors have been shown to suppress inflammation and apoptosis, stimulate angiogenesis, and amplify the proliferation and differentiation of resident cardiac stem cells (CSCs). Such features have led to exosomes being considered as potential drug candidates affording myocardial regeneration. The search for chemical signals capable of stimulating cardiomyogenesis is ongoing despite continuous debates regarding the ability of mature cardiomyocytes to divide or dedifferentiate, transdifferentiation of other cells into cardiomyocytes, and the ability of CSCs to differentiate into cardiomyocytes. Future research is aimed at identifying novel cell candidates capable of differentiating into cardiomyocytes. The observation that CSCs can undergo intracellular development with the formation of "cell-in-cell structure" and subsequent release of transitory amplifying cells with the capacity to differentiate into cardiomyocytes may provide clues for stimulating regenerative cardiomyogenesis.This work was supported by the grants from the Russian Foundation for Basic Research (Nos. 12-04-00941 and 16-04-01424) and Program of Presidium of Russian Academy of Sciences "Fundamental Sciences for Medicine" (2012-2014), by the state assignment of FASO of Russia ("The mechanisms of development of neuropsychic, metabolic, and hormonal dysfunctions in the nervous and endocrine diseases and the approaches for their correction"), and by the Government of Russian Federation, Grant 08-08.Belostotskaya, G (reprint author), Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, Grp Cytoanalysis, St Petersburg, Russia; Almazov Natl Med Res Ctr, Inst Expt Med, St Petersburg, Russia.
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Improving interoperability of catalytic sensors
No full textA huge number of combustible gas leaks occur every year at industrial and home facilities. These leaks may have grave consequences for health, environment and property. In this work we demonstrate the approach for improving the interoperability of catalytic sensors which are widely used in industrial monitoring applications for combustible gas leaks. To ensure methane detection within the broad concentration range (100 ppm–100% vol.), we propose using of two sensors with catalysts in the modified Wheatstone sensing circuit and to cover them with sealed caps with different holes to enable gas diffusion control
Compact low power wireless gas sensor node with thermo compensation for ubiquitous deployment
No full textWireless sensor networks (WSNs) have recently been applied for industrial monitoring, including combustible and flammable gases monitoring. In this work, we present a wireless gas sensor node in which a widely used Wheatstone sensing circuit based on two sensors is exchanged with a single sensor circuit, as well as the associate gas measurement procedure. The core of the measurement procedure is the four-stage heating profile, which enables low power consumption of sensing circuit and thermo compensation adjustment. A thermo compensation algorithm is capable of avoiding the effect of the environmental temperature on the measurements by keeping stable zero-offset within ±1 mV and ensuring low absolute error within 0.1% vol. The thorough design of the sensor node allows it to fit into the 5.5 cm3 packaging, which ensures its true ubiquitous deployment in outdoor and industrial environment
Modeling of Antenna System for Capsule Endoscopic Complex “Landish”
No full textAbstractThis article focuses on modeling of different options of antenna system including and in particular an antenna for the capsule endoscope (transmitter antenna) of the capsule endoscopic complex “Landish”. A helical antenna is reviewed for the transmitter, as well as a patch antenna on a curved substrate, and a quarter-wave monopole vibrator and a ceramic antenna. An experiment was conducted in order to compare the gain of the antennas at a fixed position in the space of the transmitting antennas, and the impact of the human body on the features of antennas. Recommendations on the choice of antenna systems in accordance with the simulation results are provided
Lobbies in the Making of American Foreign Policy in the South Caucdsus
No full textThe article analyzes the role of lobbies in decision-making in the U.S. toward the South Caucasus states. It also examines lobbying peculiarities of Armenia, Azerbaijan and Georgia as well as mechanisms of their influence over the Congress and American expert community. The author outlines a number of prime issues each Republic lobbies and how they refract U.S. interests in the region
Ethnocultural Factor of Inclusive Education Development (by the Examples of the Russian Federation and Kyrgyz Republic)
No full textThe article addresses the problems of inclusive education development through the prism of ethnocultural factors. A small comparative analysis of inclusive education development is given: legislative and law basis, cultural traditions in Russia and Kyrgyzstan, language and customs. The ethnocultural factor of inclusive education development is expressed through the language of “study” at schools and professional educational organizations. The author emphasizes the signs of our time – language assimilation in the countries of the former Soviet Union. It is shown that many parents in the north of Kyrgyzstan send their children, including children with disabilities, to study at Russian schools, and it causes additional barriers in learning, along with the barriers caused by physical and intellectual disabilities
Theoretical study of phase and amplitude characteristics of microwave coplanar delay line containing thin ferroelectric layer
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