1,721,395 research outputs found
sj-pdf-1-lrt-10.1177_14771535231172084 – Supplemental material for Development of a multichannel spectral simulation tool and experimental validation with different lighting scenarios
No full textSupplemental material, sj-pdf-1-lrt-10.1177_14771535231172084 for Development of a multichannel spectral simulation tool and experimental validation with different lighting scenarios by M Alwalidi, A Ganji Kheybari, S Subramaniam and S Hoffmann in Lighting Research & Technology</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Oncogenic role of cancer-associated fibroblast secretion in endometrial cancer progression in vitro and in vivo / Kavita S. Subramaniam
Get PDFCancer-associated fibroblasts (CAFs) have demonstrated tumor-promoting roles in various cancers, yet their implication in endometrial cancer (EC) has not been fully explored. CAFs and its epithelial counterpart were isolated from human EC tissues using CD90- and CD326-antibodies conjugated magnetic beads, respectively. Isolated cell populations were characterized using morphology assessment, flow cytometry, and real-time PCR. CAFs secretion increased EC cell proliferation (195.3 ± 12.9%) and enhanced motility (134.9 ± 6.5%) while benign endometrial fibroblasts inhibited proliferation (62.4 ± 21.2%) and suppressed motility (15.2 ± 8.2%). Antibody array and ELISA showed higher GRO-α, IL-6, MCP-1, VEGF and RANTES cytokines levels in CAFs, than in benign fibroblast secretion. Of note, interleukin-6 (IL-6) was secreted 4.17-folds greater in CAFs; neutralizing its effect reduced EC proliferation (36.1 ± 4.2%) while treatment of EC cells with IL-6 recombinant protein alone increased cell proliferation. Interestingly, EC cells but not CAFs expressed IL-6 receptors (IL-6R and gp-130). Upon treatment with CAFs secretion, IL-6 receptor signaling was activated as evidenced with increased phosphorylation of Erk, Akt, JAK-3 and STAT-3 proteins. Suppression of these pathways using chemical inhibitors led to reduced CAFs-mediated EC cell proliferation. Further, STAT-3 target genes (TIMP-1, PIM-1, c-Myc, SOCS-3, NFκB1 and NFκB2) were upregulated. c-Myc mRNA level was elevated 138-folds higher in CAFs-treated EC cells and c-Myc knockdown with shRNA reduced EC cell proliferation (52.7 ± 1.8%). Surprisingly, treatment with CAFs secretion did not significantly increase the cell proliferation (64.1 ± 4.7%). To observe whether CAFs modulates EC growth in vivo, epithelial and fibroblast cells were inoculated subcutaneously into nude mice. Fibroblast cells alone and co-injections of benign fibroblast with EC cells showed no induction of tumor growth. However, co-injection of CAFs with EC cells showed increased growth (1166.2 ± 59.3 mm3) compared to EC cells alone (497.6 ± 36.7 mm3). EC cells with
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reduced c-Myc expression grew into smaller tumors (293.9 ± 7.02 mm3) compared to those with high c-Myc level (748.4 ± 8.2 mm3), despite exposure to CAFs (361.9 ± 38.7 mm3). These suggest that CAFs exerts tumor-promoting effects in EC via c-Myc expression both in vitro and in vivo. Subsequent immunohistochemical analysis on human tissue specimens showed high expression of IL-6 receptors, phosphorylated STAT-3 and c-Myc protein in EC (n=9) but not in benign endometrial tissues (n=8). We further tested IL-6 receptors specific inhibitors (raloxifene and bazedoxifene acetate) and PI3K inhibitor (rapamycin) on CAFs-treated EC cells, and observed inhibition of proliferation (44.3 ± 2.6%, 46.2 ± 2.9% and 30.7 ± 12.1%, respectively), with evidence of apoptosis-mediated cell death. Our data shows that CAFs exert a growth-promoting role in EC tumor microenvironment, partly through activation of IL-6 receptors in EC cells to induce expression of c-Myc. Our study provides proof-of-principle evidence that CAFs-mediated IL-6 signaling has a direct role in EC tumorigenesis, which can be employed for novel EC therapeutic utility
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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