1,511 research outputs found
Animals and sacred bodies in early medieval Ireland: religion and urbanism at Clonmacnoise/ John Soderberg.
No full textIncludes bibliographical references and index."Clonmacnoise was among the busiest, most economically complex, and intensely sacred places in early medieval Ireland. In Animals and Sacred Bodies in Early Medieval Ireland: Religion and Urbanism at Clonmacnoise, John Soderberg argues that animals are the key to understanding Clonmacnoise's development as a thriving settlement and a sacred space"--Acknowledgments -- Figures and tables -- Introduction -- Enclosure, cattle, and sanctuary cities in early medieval Ireland -- Excavating Clonmacnoise -- Grounding the archaeology of religion -- Animals and the rise of Clonmacnoise -- Animals, tabernacles, and towns: the iconography of sanctuary -- The animals of Clonmacnoise in a new millennium -- Afterword -- Bibliography -- About the author.1 online resource
Data for: Welfare-Maximising Investors? - Utility Firm Performance with Heterogeneous Quality Preferences and Endogenous Ownership
No full textData of New Zealand's electricity distribution firms
Berättandets och läsandets konst – exemplet Hjalmar Söderberg The art of narrating and reading: the example of Hjalmar Soderberg
No full textThe issue is how narrating and reading interact in the processes of writing and reading. The ‘how’ of this double process is demonstrated by the example of a short story of the Swedish author Hjalmar Soderberg, “Tuschritnigen" [The Pen-and-Ink Drawing] (1898). The analysis shows how the textual strategies build up several different tracks of significance that conteract with one another. The basis of the analysis is reception theory (response aesthetics), but the technical terminology is limited and moved down to the critical apparatus
Cytomegalovirus-induced autoimmunity
No full textHuman cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe infections in immunocompromised patients. During active infection, the virus is able to modulate the host immune system in immunocompetent as well as immunocompromised individuals. HCMV-infected patients often develop signs of immune dysfunction, such as autoimmune phenomena. Furthermore, case reports suggest a link between primary HCMV infection and onset of autoimmune disorders. Signs of active viral infection have also been identified in a number of autoimmune diseases, which further highlights the potential role of HCMV in the genesis and/or maintenance of immunopathological phenomena. Mechanisms by which HCMV could induce host immunopathology, inflammation and autoimmunity will be discussed as well as the opportunity to administer antivirals in selected patients
The novel anti-rheumatic compound Rabeximod impairs differentiation and function of human pro-inflammatory dendritic cells and macrophages.
No full textRabeximod (9-chloro-2,3-dimethyl-6-(N,N-dimethylaminoethylamino-2-oxoethyl)-6H-indolo[2,3-b]quinoxaline) is a synthetic compound that is currently being developed for the treatment of rheumatoid arthritis (RA). Here, we investigated the effects of Rabeximod on the functionality of human antigen-presenting cells (APCs) of myeloid origin. Different subsets of professional APCs were generated from human monocytes in vitro and simultaneously treated with different doses of Rabeximod. Although Rabeximod had no effect on the differentiation of monocytes into anti-inflammatory macrophages (AI-Mφs), this compound impaired monocyte differentiation into monocyte-derived dendritic cells (MDCs) and pro-inflammatory allostimulated macrophages (Allo-Mφs). MDCs that were treated with Rabeximod resulted in a significant decrease in their ability to pinocytose antigens, while no effect was exerted by the drug on the ability of Allo-Mφs and AI-Mφs to phagocytose. Furthermore, we observed a significant reduction in the allostimulatory ability of MDCs and Allo-Mφs after treatment with Rabeximod, although this compound did not affect the low immunostimulatory capacity of AI-Mφs. Conversely, the effect of Rabeximod in influencing cytokine secretion by APCs appeared to be limited. In conclusion, Rabeximod impairs differentiation of monocytes into different pro-inflammatory APCs, leading to impaired immunostimulatory abilities of these cells. Our observations shed light on the cellular mode of action and the immunomodulatory effect of Rabeximod
Tolerance Analysis Considering form Errors in Planar Datum Features
No full textAbstractThe paper investigates the role of planar datum features in tolerance analysis problems. Mating relations between datum planes are shown to involve translational and rotational errors, which are related to form tolerances and are usually neglected in tolerance analysis. To evaluate these errors, the contact between datum planes was simulated by a stochastic model, where two surface profiles are randomly generated and then registered to reproduce a mating condition. Concepts of fractal geometry were exploited to make the generation consistent with the autocorrelation properties of actual surfaces resulting from manufacturing processes. A simulation plan allowed to predict the amount of contact errors as a function of size, tolerance and process-related assumptions on the two features. An example of 3D tolerance chain is presented to demonstrate the relevance of form errors in the variation of assembly requirements
Differential Benefit: Preschool Children, Quality of Early Childhood Education Environment and Developmental Gains Important for School Readiness
No full textThesis (Ph.D.)--University of Washington, 2014University of Washington Abstract Differential Benefit: Preschool children, quality of early childhood education environment and developmental gains important for school readiness Janet S. Soderberg Chair of the Supervisory Committee: Associate Professor Gail E. Joseph Educational Psychology This study examined children's development and learning in domains important for school readiness over the course of the 2012-2013 school year. Of particular importance was an exploration of childcare quality, school readiness, and the relationship between classroom quality characteristics and child outcomes supported by accompanying evaluative approaches. Early childhood development and the impact of classroom quality were examined in light of child and program characteristics to determine how they contribute to academic and social-emotional gains in preschool for our increasingly complex demographic of young learners. The research should help to discern the implications of current policies and practices in the state of Washington, and how best to utilize resources and build capacity in early learning communities to support children and increase their success in school. It was hypothesized that children's gains from fall to spring would be positive, and that child characteristics and classroom quality would be related to increased development and learning of children. The sample included 245 preschool children from 35 classrooms across the city of Seattle. All classrooms were included based on their participation in a citywide early learning project. Participating children were randomly selected from each classroom, with up to four boys and four girls identified for assessment. Individual child assessments included measures of language, social-emotional and cognitive skills. Classroom quality measures took the form of direct observation and record review. Hierarchical Linear Modeling was used to analyze these data, taking the nested nature of the study design into account. Results indicated a number of relationships between classroom characteristics and children's gains in the areas of letter word knowledge, math and language. Further, gains for subgroups of children, as defined by primary home language, were moderated by classroom characteristics across domains. These findings may contribute to future efforts in defining and measuring quality and school readiness as factors impacting children's successful entry into formal schooling. Through rigorous examinations of classroom quality and child outcomes, informed conclusions and decisions about Quality Rating and Improvement Systems (QRISs) can be made for determining positive trajectories for children
Detection of human cytomegalovirus in synovial neutrophils obtained from patients with rheumatoid arthritis
No full textObjectives: To examine whether signs of an active human cytomegalovirus (HCMV) infection are present in affected joints of patients with rheumatoid arthritis (RA). Method: Polymorphonuclear leucocytes (PMNLs) were obtained from synovial fluid (SF) of 17 RA patients and were analysed for HCMV-pp65 and HCMV-immediate early (IE) proteins using the antigenemia assay. Peripheral blood (PB) and SF obtained from these 17 patients and from 17 additional RA patients (n = 34) were tested for HCMV-IE and pp150 DNA with Taqman polymerase chain reaction. Plasma samples from the patients were analysed for HCMV-immunoglobulin M (IgM) and immunoglobulin G (IgG) by enzyme-linked immunosorbent assay and compared to 71 healthy gender-matched blood donors. Results: HCMV-pp65 protein was detected in 65% of synovial PMNL samples, but in only 18% of PMNLs from PB. In contrast, HCMV IE protein was not found in any of the analysed PMNL samples. On the DNA level, HCMV-IE and pp150 DNA was detected in SF of 13/32 (41%) and 14/23 (61%) of RA patients, respectively. HCMV-IE and pp150 DNA was also found in 24/33 (73%) and in 16/24 (67%) of PB samples obtained from RA patients, respectively. HCMV IgG seroprevalence was 76% in RA patients as well as in healthy controls, while only one RA patient was positive for specific IgM. Conclusions: HCMV pp65 antigen was found in PMNLs from SF of RA patients, indicating an active infection in the affected joint. Future studies are needed to determine whether HCMV infection can aggravate the inflammatory process in these patients
Recensione di Magic Mike di S. Soderbergh
No full textLa recensione evidenzia le ambiguità del film di Soderberg
Human cytomegalovirus inhibits the migration of immature dendritic cells by down-regulating cell-surface CCR1 and CCR5.
No full textDendritic cells (DC) play a key role in the host immune response to infections. Human cytomegalovirus (HCMV) infection can inhibit the maturation of DC and impair their ability to stimulate T cell proliferation and cytotoxicity. In this study, we assessed the effects of HCMV infection on the migratory behavior of human DC. The HCMV strain TB40/E inhibited the migration of immature monocyte-derived DC in response to inflammatory chemokines by 95% 1 day after infection. This inhibition was mediated by early viral replicative events, which significantly reduced the cell-surface expression of CC chemokine receptor 1 (CCR1) and CCR5 by receptor internalization. HCMV infection also induced secretion of the inflammatory chemokines CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein-1alpha (MIP-1alpha), CCL4/MIP-1beta, and CCL5/regulated on activation, normal T expressed and secreted (RANTES). Neutralizing antibodies for these chemokines reduced the effects of HCMV on chemokine receptor expression and on DC migration by approximately 60%. Interestingly, the surface expression of the lymphoid chemokine receptor CCR7 was not up-regulated after HCMV infection on immature DC, and immature-infected DC did not migrate in response to CCL19/MIP-3beta. These findings suggest that blocking the migratory ability of DC may be a potent mechanism used by HCMV to paralyze the early immune response of the host
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