659 research outputs found
Incidenza di nidi di cellule epiteliali (origine dai residui di Malassez) nei granulomi apicali.
No full textCaratterizzazione immunoistochimica delle cellule giganti multinucleate nelle epulidi a mieloplassi.
No full text
Profilo di efficacia e tollerabilità dell'escitalopram rispetto agli altri farmaci antidepressivi nel trattamento acuto della depressione maggiore: revisione sistematice e meta-analisi. [Efficacy and tolerability profile of escitalopram versus other antidepressants in the acute treatment of major depressive disorder: A systematic review and meta-analysis]
No full textAim. The aim of this study was to evaluate the efficacy and tolerability profile of escitalopram versus other commercially available antidepressants in Italy. Methods. The review was based on evidence from clinically controlled randomized trials. Studies on patients of either sex, without age limit, and with a primary diagnosis of major depressive disorder were included; exclusion criteria were psychiatric and organic co-morbidities. Efficacy was measured according to the number of treatment responders (a reduction of at least 50% in scores on a standardized scale between baseline and endpoint). Acceptability was evaluated according to the total number of study drop outs. The results are expressed as relative risk (95% confidence interval) of the total number of randomized patients (intention to treat analysis). Results. Of a total of 137 studies, only 7 controlled randomized trials met the inclusion criteria, yielding a total of 2164 patients. The efficacy of escitalopram was found to be statistically superior only to citalopram; its acceptability was marginally statistically higher than fluoxetine and citalopram. No statistically significant differences emerged versus fluoxetine and venlafaxine. Conclusion. Results suggest a statistically significant better efficacy and tolerability profile for escitalopram versus citalopram; however, owing to the small number of comparative studies conducted so far and the lack of quality evidence, it is too early to draw clinically significant conclusions about the agent's real efficacy and tolerability
Synthesis by ball milling and characterization of nanocrystalline Fe3O4 and Fe/Fe3O4 composite system
No full textThe baseline nutritional status assessed by MUST score has a low accuracy in predicting the risk of hospitalization during follow-up in patients with chronic pancreatitis: A cohort study: CP nutritional status and complications
No full textBackground: Hospitalization and death in patients with chronic pancreatitis (CP) are often due to extra-pancreatic events. Recent guidelines recommend the use of the MUST score to assess CP patients’ nutritional status, but its association with clinical outcomes has been poorly investigated. The aims of this study are to evaluate the incidence of extra-pancreatic events in patients with CP during follow-up and their association with the nutritional status. Methods: Retrospective analysis of single-centre cohort of CP patients prospectively enrolled and followed-up. Exocrine pancreatic insufficiency (EPI) was assessed by fecal elastase, MUST score calculated at diagnosis. The occurrence of hospitalizations or death were recorded. Differences between subgroups were analysed by Fisher's and T-test and hospitalization-free survival with Kaplan-Meier curves and Cox regression analysis. Results: Of 111 enrolled patients (64% male; mean age 57); 52% had alcoholic aetiology, 53% EPI, 10% severe CP and 26% a MUST score≥2 at diagnosis. During a median follow-up of 37 months, 3.6% of patients died and 34.2% needed hospitalization, in 50% of cases for extrapancreatic events (2% cardiovascular events, 8% infections and 3% cancer). There was no significant association between EPI, BMI<20 kg/m2, MUST score≥2, alcoholic aetiology and extra pancreatic events or need of hospitalization. A baseline MUST score≥2 had an accuracy of only 64.8% in predicting subsequent hospitalization. Conclusions: A sizeable portion of CP patients are at high risk of malnutrition and are hospitalized during the follow-up, often for extra-pancreatic events. The nutritional status evaluated with the MUST score lacks accuracy in predicting the risk of these events
The pathophysiology of concussion.
No full textConcussion is defined as a biomechanically induced brain injury characterized by the absence of gross anatomic lesions. Early and late clinical symptoms, including impairments of memory and attention, headache, and alteration of mental status, are the result of neuronal dysfunction mostly caused by functional rather than structural abnormalities. The mechanical insult initiates a complex cascade of metabolic events leading to perturbation of delicate neuronal homeostatic balances. Starting from neurotoxicity, energetic metabolism disturbance caused by the initial mitochondrial dysfunction seems to be the main biochemical explanation for most postconcussive signs and symptoms. Furthermore, concussed cells enter a peculiar state of vulnerability, and if a second concussion is sustained while they are in this state, they may be irreversibly damaged by the occurrence of swelling. This condition of concussion-induced brain vulnerability is the basic pathophysiology of the second impact syndrome. N-acetylaspartate, a brain-specific compound representative of neuronal metabolic wellness, is proving a valid surrogate marker of the post-traumatic biochemical damage, and its utility in monitoring the recovery of the aforementioned "functional" disturbance as a concussion marker is emerging, because it is easily detectable through proton magnetic resonance spectroscopy
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