509 research outputs found
A. Sigala, Ἱστορία τῆς ἑλληνικῆς γραφῆς
No full textS. E. A. Sigala, Ἱστορία τῆς ἑλληνικῆς γραφῆς. In: Échos d'Orient, tome 34, n°179, 1935. p. 379
Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019–2021
No full textPurpose of review comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC. Recent findings 423 studies were published between 2019 and 2021. After manual curation we summarized selected evidence in two thematic areas: Germline deoxyribonucleic acid (DNA) variations, genomic alterations and prognosis. Summary the evolving genomic landscape of ACC requires target validation in terms of prognostic and predictive value within scientific consortia. Although the existing multiple driver genes are difficult targets in the perspective of precision oncology, alterations in DNA damage repair genes or in promoter hypermethylation could open new venues for repurposing of existing drugs in ACC
Kajian Struktural dan Konflik Sosial pada Wayang Orang Balai Sigala-gala serta Relevansinya sebagai Materi Ajar Bahasa Jawa Pembentuk Sikap Sosial Siswa SMA
No full textKartika Rahmat Sari Dewi. A STRUCTURAL STUDY AND SOCIAL CONFLICT OF WAYANG ORANG BALAI SIGALA-GALA AS WELL AS ITS RELEVANCE AS THEACHING MATERIALS OF JAVANES LANGUAGE LEARNING IN SENIOR HIGH SCHOOL. Thesis, Surakarta: Javanese Language Education. Theacher Training and Education Faculty. Sebelas Maret University, July 2015. This research aimed to study structural element and social conflicts existing in Wayang Orang Balai Sigala-gala video and to find out whether or not it was relevance to be used as the teaching materials of Javanese language learning in the Senior High School. This study employed a descriptive qualitative approach with content analysis type of research by exploring structural elements and social conflicts in Wayang Orang Balai Sigala-gala and its relevance to be learning media. The information source used included reference book, video, informant as informant of interview. Techniques of collecting data used were Library Research as well as in-depth interview with data validation test using data source triangulation in which the author incorporated data obtained from interview of informant and the data obtained from reference study ad content analysis on the research object. The result of the research showed that Wayang Orang Balai Sigala-gala had complete structural elements, just like the constructive element existing in prose genre generally. The social conflict study conducted indicated that Wayang Orang Balai Sigala-gala had social conflict constituting the reflection in current social condition on society to be analyzed easily by the studied in the Senior High Schools. The consistency of conflict existing in Wayang Orang Balai Sigala-gala with the social condition made this video relevant to be a teaching materials into Javanese Language learning. Considering the result of research, it could be concluded that Wayang Orang Balai Sigala-gala was relevant to be teaching materials to Javanese Language Learning in the Senior High Schools. Key words: wayang wong, puppets, conflict, character education
Epilogue: An ecosystems framework for studying Wine Tourism-Actors, Co-creation Processes, experiences and outcomes
No full textAdrenocortical carcinoma
No full textAdrenocortical carcinoma (ACC) is an extremely rare disease, the incidence of which is 0 [...]
Should we be cautious on the use of commercially available antibodies to dopamine receptors?
No full textThe guanine nucleotide exchange factor VAV2 as a new prognostic parameter in adrenocortical carcinoma
No full textNerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism
No full textTwo different human prolactinoma phenotypes (responders and nonresponders), which are distinguished by different tumorigenic potential and different responsiveness to dopaminergic therapy, have recently been identified. Responders show low proliferation rate, low tumorigenic potential, and expression of D-2 receptors for dopamine (DA), while nonresponders are characterized by high proliferation rate, high tumorigenic potential, and lack of expression of DA D-2 receptors. In this study it has been shown that both gp140trk and gp75 components of nerve growth factor (NGF) receptor are expressed in responder prolactinoma cell lines. High levels of both NGF gene transcript and protein were also found in responders, and biologically active NGF was detectable in the media conditioned by these cells. Ablation of NGF production in responder cells by hybridization arrest of translation through NGF antisense oligonucleotides resulted in: 1) loss of secreted NGF; 2) loss of expression of gp75; 3) loss of expression of DA D-2 receptors; and 4) a remarkable increase in the cell proliferation rate. These results thus suggest that a NGF-mediated autocrine loop essential to control cell proliferation and to preserve some phenotypical characteristics of mammotroph cells is present in responder prolactinoma cell lines. Analysis of nonresponders showed that these cells express gp140trk but no detectable levels of gp75. In addition, no NGF mRNA or protein was detectable in nonresponders. Exposure of these cells to NGF resulted in the permanent expression of NGF mRNA and in the production and secretion of NGF protein, thus establishing the same NGF-mediated autocrine loop present in responders. As a result, it has been shown that nonresponder cells treated with NGF acquire and maintain most of the phenotypic characteristics of normal mammotroph cells. In conclusion, the present work reports that a NGF-mediated autocrine loop with an inhibitory role in the control of cell proliferation and tumor progression is active in the more differentiated DA-sensitive prolactinoma cell lines and is lost in the most malignant prolactinoma cells refractory to the dopaminergic therapy. Alterations in the expression of this autocrine loop thus may lead to cell transformation and tumor progression
1,25(OH)2 vitamin D(3) contributes to osteoclast-like trans-differentiation of malignant plasma cells
No full text1,25-dihydroxyvitamin D (1,25(OH)2D) exerts pleiotropic effects including bone turnover and immune system regulation. It inhibits both T and B cell proliferation while decreasing the secretion of inflammatory cytokines and immunoglobulins. 1,25(OH)2D also modulates monocyte-macrophage and osteoclast (OC) maturation. Since we have previously described that malignant plasma cells may trans-differentiate towards the myeloid lineage participating to skeletal devastation in multiple myeloma (MM), we here evaluated in vitro the role of 1,25(OH)2D in this lineage switch. We investigated the gene and protein expression of vitamin D receptor (VDR) in MM cell lines. Thus, after cell treatment with 1,25(OH)2D, we analyzed their morphology and the expression of myeloid and OC markers. Finally, we assessed their bone resorption property on calcium phosphate slices. All MM cells expressed VDR in nuclear and perinuclear sites. Treatment with 1,25(OH)2D altered their morphology from round to fusiform, while inducing paxillin focalization. 1,25(OH)2D administration also up-regulated myeloid and OC genes, including C/EBPα RANK, M-CSFR and V-ATPase, whose promoters contain potential 1,25(OH)2D responsive elements. Finally, 1,25(OH)2D increased MM cell capability to generate pits of erosion on calcium phosphate discs. This data suggest that myeloma cells may undergo a functional trans-differentiation into OCs and, under appropriate experimental conditions, 1,25(OH)2D triggers this lineage switch
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