603 research outputs found

    Advanced skills and research

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    The health organisation has recently been placing emphasis on the importance of the fundamental rights of the individual, promoting an idea of health seen not only from the biological point of view but also and above all in its psychological, relational and social aspects. [...]

    Cell proliferation and apoptosis in the pathogenesis of oesophagogastric lesions in pigs

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    Recent studies have stressed the importance of epithelial hyperproliferation in the pathogenesis of early lesions (parakeratotic hyperkeratosis) of the porcine gastric pars oesophagea (PO). In this study, immunohistochemical staining with Ki67 (clone MIB 1) and AgNOR proteins silver staining were used to evaluate, by means of image analysis, cell proliferation in normal and parakeratotic (parakeratotic hyperkeratosis) epithelia of the PO. Apoptotic activity was also assessed with the TUNEL assay and compared with cell proliferative parameters. Early lesions of the PO were characterised by a significant increase in epithelial proliferative activity while there was no difference in the apoptotic activity between normal and parakeratotic epithelia. Our data confirm the hyperproliferative nature of epithelial changes preceding degeneration and erosion/ulcer of the PO and suggest that an underlying feature of gastric ulcers in pigs is an imbalance between cell proliferation and programmed cell death. © 2000 Harcourt Publishers Ltd
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