231 research outputs found
Of Restoring Compliance, Lex Specialis and Intersecting Wrongs: the Question of ‘Remedies’ in Gabčíkovo-Nagymaros
No full textLoris Marotti and Paolo Palchetti discuss the innovative and case-specific treatment of remedies in Gabčíkovo-Nagymaros, which explains the case’s relatively limited influence specifically as regards the consequences of internationally wrongful acts. At the same time, the Court’s approach finds an echo in the flexibility of the rules on reparation adopted in the framework of the ilc codification exercise
”Ricerca sul traffico marittimo in ambito regionale: attività sperimentale V.T.S. nell'area del golfo di Cagliari”
No full textPractical tips and new trends in electrochemical biosensing of cancer-related extracellular vesicles
No full textTo tackle cancer and provide prompt diagnoses and prognoses, the constantly evolving biosensing field is continuously on the lookout for novel markers that can be non-invasively analysed. Extracellular vesicles (EVs) may represent a promising biomarker that also works as a source of biomarkers. The augmented cellular activity of cancerous cells leads to the production of higher numbers of EVs, which can give direct information on the disease due to the presence of general and cancer-specific surface-tethered molecules. Moreover, the intravesicular space is enriched with other molecules that can considerably help in the early detection of neoplasia. Even though EV-targeted research has indubitably received broad attention lately, there still is a wide lack of practical and effective quantitative procedures due to difficulties in pre-analytical and analytical phases. This review aims at providing an exhaustive outline of the recent progress in EV detection using electrochemical and photoelectrochemical biosensors, with a focus on handling approaches and trends in the selection of bioreceptors and molecular targets related to EVs that might guide researchers that are approaching such an unstandardised field
Efficient coupling of a graded index glass guide to a polymer guide by means of a tapered transition
No full textA four layer tapered coupler was designed and characterised. The designed device was able to couple the optical power guided in a commercial monomode optical fiber into an organic thin film waveguide with 3 dB overall power losses
Die notwendige Nichtaktualität des Fundaments. Anmerkungen aus der Sicht von Ernst Blochs „Naturrecht und menschliche Würde“
No full textInductive and noninductive conditions on in vitro tuberisation and microtuber dormancy in potato (Solanum tuberosum subspecies tuberosum and subspecies andigena)
No full textThe effect of growth conditions (medium and photoperiod) on in vitro tuberisation and microtuber dormancy of the cv. Désirée (Solanum tuberosum subspecies tuberosum) and Imilla Negra (Solanum tuberosum subspecies andigena) was evaluated. The short photoperiod and presence of CCC in the medium reduced the dry matter of plants as well as the size of microtubers. The two cultivars showed a difference, in favour of Désirée, in the percentage of plants having more than one tuber and in the average time of sprouting after storage. The average time of sprouting was more rapidly obtained under long days and in a medium without CCC. The CCC and short days caused the same dormancy conditions and the same K+ quantity in the microtubers. The microtubers mineral composition is involved in the dormancy status
The role of peptides in the design of electrochemical biosensors for clinical diagnostics
No full textPeptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described
Gli Spettacoli di Prosa dal 1804 al 1945
No full textIl teatro all'italiana, con i suoi palchetti, il palcoscenico in declivio da un lato e il palco reale
dall'altro, è la tipologia teatrale più diffusa nel mondo. Eppure, quando si tenta di analizzarla più
da vicino per precisarne gli elementi costitutivi, questa celebre architettura si fa sfuggente: ci sono
infatti teatri all'italiana senza palchetti, senza declivio, o magari senza palco reale
Impact of the protein corona on nanomaterial immune response and targeting ability
No full textOver the last decade nanomaterials have had a major impact on human health for the early detection and treatment of many diseases. The future success of clinically translatable nanomaterials lies in the combination of several functionalities to realize a personalized medical experience for patients. To maintain promises, concerns arising from toxic potential and off-target accumulation of nanomaterials must be addressed first. Upon introduction to a complex biological system (e.g., following systemic administration), nanomaterials interact with all the encountered biomolecules and form the protein corona, a complex coating of plasma proteins that provides them with a totally new biological identity. As the protein corona controls the nanomaterial behavior in vivo, a precise knowledge of the relationship between biological identity and physiological response is needed but not yet achieved. Based on impressive progress made thus far, this review critically discusses how the protein corona activates immune response and influences the targeted delivery of nanomaterials. Furthermore, we comment on emerging strategies to manipulate protein binding in order to promote formation of designer artificial coronas and achieve a desired therapeutic outcome. We conclude by debating challenges that must be overcome to obtain widespread clinical adoption of nanomaterials. This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Therapeutic Approaches and Drug Discovery > Emerging Technologies
Exploitation of nanoparticle-protein corona for emerging therapeutic and diagnostic applications
No full textExposure of nanoparticles (NPs) to biological fluids (e.g., plasma, interstitial fluid, and cytoplasm) leads to the absorption of proteins on the NP surface, forming a protein corona (PC) that drastically influences the NP physicochemical properties. Herein, we highlight the emerging applications of PC towards its use in therapeutics and diagnostics. In particular, special emphasis is given to the exploitation of PC for targeted delivery of nanomaterials and early cancer detection. By highlighting such recent applications of PC, we hope to demonstrate that this bio-entity has the potential to determine the success of NPs in biomedicine beyond their currently envisioned purposes
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