5,662 research outputs found
A grammar of sentiment thinking about sentimental jewellery towards making new art about love and loss.
No full textSubmitted in partial fulfilment of the requirements of the University of Wolverhampton for the Degree of Doctor of PhilosophyThis practice-led research project explores English and French sentimental jewellery of the Victorian period. ‘Sentimental jewellery’ or ‘message jewellery’ denotes jewellery created to function as a tangible expression of feeling between donor and recipient, mediated through complex narratives relating to its exchange. These artefacts codify emotion through use of complex visual languages, employing the symbolic and coded use of gems, human hair, emblems, words and wordplay. The research has expanded to encompass memorial garments known as ‘widows weeds’. The aims of the research have been threefold: firstly, to add to understanding and interpretation of aspects of Victorian sentimental jewellery and associated craft practices; secondly, to explore the metaphors and narratives inherent within them; thirdly, to test the visual and technical possibilities of knowledge thus gained to address human feeling through art. Outcomes take the form of a body of new artwork and a written thesis, which are designed to be mutually informing. Together, they articulate my response to the project’s central question: can consideration of the ‘grammar of sentiment’ at work in Victorian sentimental jewellery yield new possibilities, through fine art practice, for communicating love and loss in the 21st century? The four artworks that are a main output of the research take the forms of: REGARD:LOVEME, an artist’s book exploring gem codes and wordplay; Plocacosmos, a set of hairworking trials; The Cyanotypes, which reflect upon the materiality and aesthetic of the amatory locket; and Widows Weeds, a large format photographic installation, which considers the materiality and lineage of mourning cloth. Collectively, they explore the typology of the sentimental artefact through development of text/image vocabularies that are conceived as providing a ‘grammar of sentiment’ through which to articulate aspects of human feeling. It is this exploration that constitutes my main contribution to knowledge
THE AI REVOLUTION: TRANSFORMING INDUSTRIES AND SOCIETY
No full text<p>Author: Vinit Parmar </p><p>Designation: Founder and CEO of The Flyhyer </p><p>Affiliation: The Flyhyer </p><p>Contact Number: 9099972157 </p><p>Email Address: [email protected] </p><p>Address: At Post Bhalod, New Vashahat Parmar Faliya, House No. 1171 District: Bharuch Taluka: Jhaghadia</p>
Contact lens-based expansion and transplantation of autologous epithelial progenitors for ocular surface reconstruction: Crossover control
No full text[No abstract available]Di Girolamo N, 2009, TRANSPLANTATION, V87, P1571, DOI 10.1097-TP.0b013e3181a4bbf2; Ozbek Z, 2006, CORNEA, V25, P245, DOI 10.1097-01.ico.0000176602.49258.ea; Parmar DN, 2006, AM J OPHTHALMOL, V141, P299, DOI 10.1016-j.ajo.2005.09.0080
A Guide to BAS Controls for Educational Use
No full textThis video from the Building Efficiency for a Sustainable Tomorrow (BEST) Center features a presentation by Harpartap Parmar, Director of Product Management at Contemporary Controls. This presentation was given at the 2025 BEST Annual Institute: Ensuring Sustainability: Energy Efficient Buildings &amp; Technician Education.Contemporary Controls is a firm that &quot;designs and manufactures system building blocks&quot; for building automation processes. This presentation outlines the firm&rsquo;s open educational resources, which include an open source programming language and free software tools. Parmar details the free programming tools in the BAScontrol Toolset, the BASemulator tool, and pre-built applications. The speaker shares an example of a classroom setup using BAScontrollers, and provides examples of implementations at two community colleges.&nbsp;This video runs 00:25:14 minutes in length. Other videos in this series are available to view separately
Workflow Driven Decision Support Systems: A case of an intra-operative visualization system for surgeons
No full textInadequate visualization during Minimally Invasive Surgeries (MIS) has led several technology research labs to develop decision support systems such as Intra-operative Visualization Systems (IVS). IVS focuses on providing surgeons with real-time imaging support to improve task visualization and navigation. Though exciting, this emerging field also presents challenges in terms of design, development, implementation and integration of various technologies in the surgical workplace. While developing a technically robust IVS which integrates various imaging sources may help visualizing the patient data, it may not serve its true purpose: to adequately support surgeons in making the right decisions. Development of IVS should therefore be not just “technology intensive”; but “Knowledge Intensive Visualization System (KIVS)”. This means that these systems should aim to provide the knowledge to make informed decisions by providing the surgeon with the necessary patient information. This thesis is an example of the role design as a discipline can play in guiding the user-centered technological innovation in the area of medical informatics, especially in the case where the development depends on creating collaborative design between different scientific disciplines: surgical, technological (medical informatics) and design. Visualization of the patient information which supports surgical decision making in KIVS is dependent on knowledge of surgical workflow- which means knowledge of how surgeons solve problems and make decisions while performing the procedure. Surgical workflow depends on a dynamic information flow between the system, the surgeon, the patient, and the surgical team. Surgical workflow is also linked in time over the three surgical phases: pre-operative (before surgery), intra-operative (during surgery), and post-operative (post surgery). This thesis focuses on answering the following research questions: (a) What are the constituents or task boundaries of the surgical workspace that influence the surgical workflow or the surgical problem-solving process? (b) How can the knowledge of the surgical workflow be incorporated into the design of KIVS so as to improve decision-making and thus the performance of the surgeons?(c) In a multidisciplinary development team of surgeons, technology engineers and designers, what steps are required in the KIVS development process to facilitate collaborative design? Based on empirical studies with surgeons, this thesis proposed a design framework called “Workflow-centered design framework”. This framework assists in analyzing the surgical workflow which eventually leads to the development of the knowledge repository of surgical procedure, information and design requirements for the KIVS. This framework has been applied to support workflow driven development of two KIVS prototypes taking a case of upcoming MIS to treat cancer in liver called Radio frequency Ablation (RFA). These prototypes have been developed involving real-time image fusion between imaging modalities such as intra-operative Ultrasound (US) and pre-operative Computerized Tomography (CT) scan. The results from the evaluative study showed significant improvements in the performance of expert intervention radiologists and medical students while performing RFA using KIVS compared to US. In particular, intra-operative planning time and task accuracy of hitting the right tumor in the center showed significant improvement. The findings demonstrated the importance of workflow driven patient data visualization in improving surgical decision making. The framework proposed in this thesis serves as a means to generate the scientific knowledge required to drive user-centered development of KIVS. The contribution of this thesis is at three levels: - The framework proposed in this thesis contributes to design and ergonomics literature as a practical example of application of user centered design to drive innovative technological development of KIVS for complex workspaces such as the surgical theatre. - It contributes to the medical informatics by integrating cognitive theories as a foundation which guides the development of KIVS. - The KIVS prototype serves as a development aid to guide future technological innovation in the area of intra-operative visualization system for RFA and for MIS in general.Product Innovation ManagementIndustrial Design Engineerin
Coumarins as antioxidants.
No full textCoumarins, a well-known class of naturally occurring compounds, display a remarkable array of biochemical and pharmacological actions, some of which suggest that certain members of this group of compounds may significantly affect the function of various mammalian cellular systems. The development of coumarins as antioxidant agents has attracted much attention in recent years. Coumarins afford an opportunity for the discovery of new antioxidants with truly novel mechanisms of action. This review updates and expands the 2006 review by the same author. The review considers and incorporates the most recently published literature on coumarins as related to their antioxidant properties. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogues. Beyond doubt, a deep understanding of the mechanisms of existing synthetic and natural coumarins will build the basis for the rational design
Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in vitro and in vivo.
No full textWe have earlier conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed modifications of functional proteins such as cytochrome-P450-linked mixed function oxidases (Cyt-P450-linked MFOs), NADPH cytochrome c reductase, and glutathione S-transferase by acetoxy derivatives of polyphenols. In this study, we have investigated the comparative specificities of CRTAase to N-acetyl derivative, 7-acetamido-4-methylcoumarin (7-N-AMC), O-acetyl derivative, 7-acetoxy-4-methylcoumarin (7-AMC), S-acetyl derivative, 7-thioacetyl-4-methycoumarin (7-S-AMC) and their parent compounds in the modulation of catalytic activities of aforesaid proteins. Special attention concentrated on the comparative inhibitory effect of aforesaid acetyl moiety on Cyt-P450-linked MFOs such as 7-ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-dealkylase (PROD) and aflatoxin B1 (AFB1)-induced genotoxicity in vitro and in vivo. The results clearly indicated that N-acetyl and O-acetyl derivatives were better substrates for CRTAase while the S-acetyl was found to be a poorer substrate. Our study involving atomic charge, charge density and molecular electrostatic potential (MEP) calculations indicated the pivotal role of electronegativity and charge distribution values of O, N and S atoms of the acetyl group at C-7 position of the 4-methylcoumarins in CRTAase activity. These facts reinforce our hypothesis that the CRTAase catalyzed modifications of the catalytic activities of aforesaid proteins by acetyl derivative of 4-methylcoumarins is probably due to acetylation of these proteins. © 2012 Elsevier Ltd
Royston−Parmar flexible parametric survival model to predict the probability of keratoconus progression to corneal transplantation
No full textPurpose: To assess a Royston−Parmar flexible parametric survival model to generate a personalised risk profile for keratoconus progression. Methods: We re-analysed a historic database of 2723 individuals with keratoconus. A Royston−Parmar survival model was fitted to predict the likelihood of the worse eye progressing to corneal transplantation. We used a backwards selection multivariable fractional polynomial procedure to assist with selection of covariates and identify appropriate transformation(s) to retain in the final model. Time-dependent receiver operating characteristic (ROC) curves from censored survival data using the Kaplan−Meier (KM) method were computed to visually assess how well the model identified eyes likely to progress. Results: In all, 5020 eyes from 2581 patients were available for model development. This included 2378 worst affected eyes, and 313 eyes that progressed to transplantation. The best fitting model [df = 1: Bayes information criterion (BIC) = 1573] included three variables, keratometry [hazard ratio (HR) 0.36: 95% confidence limits (CI) 0.32–0.42], age at baseline [HR 0.97: CI 0.95–0.99] and ethnicity [HR 3.92: CI 2.58–5.95]. Specificity at 1 year was 92.8% (CI 90.4−95.2%) with a corresponding sensitivity of 64.6% (CI 58.9−60.0%). These three prognostic factors account for 41.3% (CI 33.6 – 48.2%) of the variation among the survival curves. Conclusion: Researchers should consider the Royston−Parmar model as an alternative to the Cox model. We illustrate the concepts and our results may lead to better tools that identify individuals at high risk of keratoconus progression.</p
Highlights of Library Automation related documents in the INSPEC
No full textThe paper has attempted to analyse the Library Automation related records in the INSPEC (1969 to July 2004). The growth of Library Automation related literature, country of input, scattering of literature in different publication types, core journals publishing Library Automation related publications, language-wise proportion of the literature, content analysis through keywords/descriptors, availability of URLs (Universal Resource Locator) for full text articles as alternative locations were the main focus of the study. After the year 1984, the literature grows approximately linearly with a growth rate of about 600 items per year. The USA is the predominant publishing country of Library Automation related literature. Journals are the most preferred publication media, followed by Conference/Proceedings-Papers, Book-Chapters, and Reports publications. Most productive journals are: Library Hi Tech, followed by Computers in Libraries, VINE, Information Technology and Libraries, and Program. English articles constitute 91.83% of the total literature. That means the non-English articles constitute only 8.17%. The keyword analysis indicates that the key areas of Library Automation were cataloguing; academic-libraries; information-retrieval; Internet; and information-services. The most occurred URL was http://www.dlib.org/ as alternative locations in the availability notes of Library Automation related records
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