703 research outputs found
A data report on the effect of terrain types on the windcatcher's performance
No full textThree-dimensional steady CFD simulations were conducted to produce the numerical raw data, including the ventilation performance indexes, to investigate the natural ventilation capability of a bidirectional windcatcher in the presence of the free wind stream disturbed by the different types of terrain. In order to produce the data, a step-by-step process was followed. The generated geometry of the building model along with its two-sided windcatcher (in Rhino) was imported into the Hexpress software to build up the computational grid and finally it was fed to ANSYS Fluent to run the simulations following the predefined numerical solution settings. The calculated simulations produced the flow field and temperature distribution inside the generic building exposed to the wind flow with a reference wind speed of 3.1 m/s at the reference height of 10 m (wind condition of the city of Nottingham, the UK). The effect of four various ground surface features (open, rough, suburban and urban areas) and two different thermal scenarios (outdoor temperatures of 21.5 ºC and 26 ºC) on the wind flow and indoor thermal conditions was studied. The reported numerical data contributes to future numerical and experimental investigations toward aerodynamic design improvements for the windcatchers
Das osmanische Reich in seinen Archivalien und Chroniken : Nejat Göyünç zu Ehren / hrsg. von Klaus Kreiser und Christoph K. Neumann
No full textBeitr. teilw., dt., teilw. engl., teilw. türk. - Bibliogr. N. Göyünç S. XI - XXIIIIntermediärsprache: EnglischIntermediärsprache: TürkischIl
Correction to: High genetic heterogeneity of leukodystrophies in Iranian children: the first report of Iranian Leukodystrophy Registry (neurogenetics, (2023), 10.1007/s10048-023-00730-y)
No full textThe published online version of the original article contains a mistake. The authors would like to correct the affiliation of Dr. Nejat Mahdieh as linked above. His work affiliations are listed below. 26Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran 31Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. The authors would like to apologize for any inconvenience caused. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature
Potential genetic risk factors are associated in young and old patients gruops with thrombosis
No full textAccording to The World Health Organization (WHO)?s data, cardiovascular diseases the leading cause of death With respect to WHO?s estimate, worldwide 17,5 million people has lost their lifes because of cardiovascular diseases in 2005. In Turkey cardiovascular diseases is one of the deadly diseases as all over the world. Thrombosis is a disease with many factors where inherited and acquired factors is acting together or alone. The aim of this study was to evaluate the effect of some cardiovascular, thrombotic risk factors on longevity such as FV 1691 G-A, PT 20210 G-A, MTHFR 677 C-T and ACE I/D and to determine the role of combination of mutations in young and old groups.In our study as a clinical thrombosis of age between 0?18, 362 individual, 70 years and over 209 individual, with 332 individual in the 0?18 age range do not have thrombosis 70 years and over 266 individuals were included. DNA was extracted by classical phenol-clorofrom method and genotyping of FV 1691 G-A, PT 20210 G-A, MTHFR 677 C-T polymorphisms were performed by Real-Time PCR technique. Genotyping of ACE I/D polymorphism, perfect- matched primers used to amplify the target region and agarose gel electrophoresis was performed for the identification of this polymorphism.In the two age groups between healty 8 patient groups FV 1691 G-A, PT 20210 G-A, MTHFR 677 C-T and ACE I/D polymorphisms were not found statistically significant when analyzed one by one. But our study showed that when analyzed together these polymorphisms are thrombotic risk factor in the studied groups.Tez No İndirme Tez Künye Durumu
275445 Pdf dosyası
Genç ve yaşlı trombozlu hasta gruplarında olası genetik risk etmenlerinin değerlendirilmesi / Potential genetic risk factors are associated in young and old patients gruops with thrombosis
Yazar:DİLARA FATMA AKIN
Danışman: PROF. DR. NEJAT AKAR
Yer Bilgisi: Ankara Üniversitesi / Biyoteknoloji Enstitüsü / Temel Biyoteknoloji Ana Bilim Dalı
Konu:Genetik = Genetics ; Hematoloji = Hematology
Dizin: Onaylandı
Yüksek Lisans
Türkçe
2010
115 s.
Dünya Sağlık Örgütünün (WHO) verilerine göre kalp damar hastalıkları ölüm sebeplerinin ilk sırasında yer almaktadır. Tahminlere göre 2005 yılında Dünya genelinde 17.5 milyon insan kalp ve damar hastalıkları nedeni ile yaşamını yitirmiştir. Türkiye'de de kalp ve damar hastalıkları tüm Dünya da olduğu gibi ölümcül hastalıkların ilk sırasında gelmektedir. Bu hastalıklar içinde bulunan tromboz çok sayıda kalıtsal ve edinsel etmenin tek başına ya da birlikte seyrettiği çok etmenli bir hastalıktır. Bu çalışma; FV 1691 G-A gen değişimi ile birlikte, PT 20210 G-A, MTHFR 677 C-T ve ACE I/D gen değişimlerinin genç ve yaşlı çalışma gruplarında tromboza ve dolaylı olarak da uzun yaşama olan etkisinin, Türk toplumunda değerlendirilmesi amacı ile gerçekleştirilmiştir.Çalışmamıza klinik olarak tromboz geçiren 0?18 yaş aralığında 362, 70 yaş ve üzeri 209 birey, tromboz geçirmeyen 0?18 yaş aralığında 332, 70 yaş ve üzeri 266 birey dâhil edilmiştir. Klasik fenol- klorofrom yöntemi ile ayrılan DNA örneklerinde FV 1691 G-A, PT 20210 G-A ve MTHFR 677 C-T gen değişimlerinin tespiti için Real- Time PCR tekniği kullanılmış ve erime eğrisi incelemesi yapılmıştır, ACE I/D polimorfizmi tespiti için ise uygun primerler kullanılarak istenilen bölge Klasik PCR tekniği ile çoğaltılmış ve agaroz jel elektroforezinde sonuçlar değerlendirilmiştir.FV 1691 G-A MTHFR 677C-T, PROTROMBİN 20210 G-A ve ACE I/D gen değişimleri tek başına incelendiğinde, yaş gruplar
A Novel Effective Lightweight Homomorphic Cryptographic Algorithm for data security in cloud computing
No full textCloud computing is a technology in which the resources are delivered as services. Users can access them anywhere, anytime via the Internet without any need to know the infrastructure knowledge, experience, or even authority that provides such services. It has become an important medium for enterprises to develop their networks because of these resources. With the growing need for cloud computing, security is becoming important for both individuals and business needs. Many researchers have studied the security of cloud computing. Still, security gaps or threats are increasing as the demand for cloud computing connectivity increases. Because a third party mostly provides cloud platforms to the cloud client, data protection in the cloud is the primary issue. This paper presents a novel, effective lightweight homomorphic cryptographic algorithm which contains two layers of encryption. The first layer uses the new effective, light-weight cryptographic algorithm and the second layer multiplicative homomorphic schemes considered for improving security data in cloud computing. This approach offers both symmetric and asymmetric cryptography features. The proposed approach's performance is evaluated using a variety of metrics, including memory, computational time and (key sensitivity), statistical analysis, image histogram, and entropy change analysis. The proposed algorithm's experimental findings showed a high level of security and an apparent improvement in encryption execution time, memory usage, and throughput. When compared to the cryptographic systems widely used in cloud computing. © 2022 The Author
Noncooperative Foundations of the Area Monotonic Solutions.
No full textGiven a finite set of alternatives, players alternate making offers. Player one offers some alternative that player two can accept or veto. If player two accepts, it is enforced and the game ends. Otherwise, player two makes a counteroffer among the remaining alternatives and so on. If all alternatives are vetoed, a disagreement alternative is enforced. First, the author characterizes the unique outcome of any subgame perfect equilibrium of this game. Then, the author shows tha t this outcome converges to the area monotonic solution if the alternatives are uniformly distributed over the bargaining set and a s the number of alternatives tends to infinity. Copyright 1993, the President and Fellows of Harvard College and the Massachusetts Institute of Technology.
Genetic Deletion of the Heat Shock Protein DNAJB3 Exacerbates Diet-Induced Obesity and Associated-Metabolic Dysfunctions
No full textThe escalating prevalence of obesity and its associated metabolic disorders, including Type 2 Diabetes (T2D), poses a significant global health challenge with profound economic implications. These metabolic diseases have both genetic, environmental and gene x environment etiologies. This dissertation investigates the role of a specific gene product, the DNAJB3, a member of the heat shock protein family, in modulating dietary obesity-related outcomes. Additionally, it aims to elucidate the complex interplay between genotype, diet, and sex effects on metabolic parameters. Individuals with obesity and T2D were found to express reduced DNAJB3 expression levels, which was partly restored by physical activity. Accordingly, we hypothesized, the lack of DNAJB3 will lead to increased body weight, fat mass, aggravated glucose intolerance and heightened inflammation in diet-induced obese mice. To test this hypothesis, we used a comprehensive methodology, including the generation of DNAJB3 knockout (KO) mice (KO 30, 44 and 47) via CRISPR-Cas9 technology and metabolic phenotyping. In our initial animal study, we observed that compared with Wild type (WT) mice, male and female KO 47 mice demonstrated higher body weight and fat mass. Additionally, KO 47 mice exhibited a diminished rate of glucose clearance in the Glucose Tolerance Test (GTT), consistent with decreased mRNA expression of the glucose transporter 4 (Glut4) gene in white adipose tissue (WAT), but not in the muscle. Both male and female KO 47 mice exhibited elevated mRNA levels of the pro-inflammatory marker tumor necrosis factor (Tnf ) in WAT only. Furthermore, increased mRNA levels of the monocyte chemoattractant protein 1(Mcp1) and the ER stress marker immunoglobulin binding protein/glucose regulated protein (Bip/Grp78) were observed solely in male KO 47 mice, with no such changes observed in females. However, above alterations were not observed in the other KO lines. The above study reveals critical involvement of DNAJB3 in metabolic dysfunctions associated with obesity. Specifically, DNAJB3 deficiency (KO 47) exacerbated adverse metabolic outcomes, including glucose intolerance and fat mass, particularly under Texas Tech University, Shadi Nejat, May 2024 X obesogenic conditions. Notably, these effects were more pronounced in female mice, highlighting the influence of sex on metabolic regulation. Since the KO 47 line had the largest DNA deletion generated by CRISPER-Cas9, which also resulted in the elimination of the start codon, we designed the next experiments using KO 47 to compare responses to low fat vs. high fat diets and sex differences. Moreover, we used KO 47 as its phenotype was also consistent with previous observations reported in the human studies. We demonstrated that, KO mice females exhibited elevated body weight and fat mass compared to their WT littermates under the same dietary conditions Moreover, in both males and females, HF-fed KO mice demonstrated slower rates of glucose clearance, as by GTT, compared to the other groups. Interestingly, these findings were more significant across the board in the female HF-KO group, compared to the other groups. Leptin levels in serum were significantly higher in female HF KO groups compared to LF groups and HF WT group (P<0.0001). In males the HF KO had a significantly higher leptin level compared to HF WT (P=0.0036), LF KO (P=0.0002) and LF WT (P<0.0001). Additionally, in females, the mRNA expression level of Glut 4was significantly lower in WT fed LF diet compared to KO fed the same diet (P<0.0001), and significantly lower in the HF fed groups compared to LF KO (KO: P=0.0009) (WT:P=0.0065). Our findings not only underscore the translational relevance of DNAJB3 in metabolic health but also offer potential therapeutic targets for obesity-related disorders. By unraveling the intricate molecular mechanisms underlying DNAJB3-mediated metabolic regulation, we identify pathways such as glucose homeostasis, insulin signaling, and lipid metabolism as potential targets for therapeutic interventions beyond gene therapy using DNAJB3. To further investigate whether the metabolic phenotype observed in female KO 47 were due to direct effects of the DNAJB3 deficiency on adipose tissue, we isolated stroma vascular cells from WAT and cultured them. Undifferentiated preadipocytes and differentiated adipocytes from these stroma vascular cells of WT and KO mice were then treated with lipopolysaccharide (LPS) to induce inflammation then interleukin 6 (IL 6) secretion from adipocytes was measured in culture media. However, no differences were detected between WT and KO mice in their response to LPS. Texas Tech University, Shadi Nejat, May 2024 XI Overall, our findings hold profound implications for translational research and future investigations aimed at developing personalized therapeutic approaches for obesity and related metabolic disorders. In addition to exploring gene therapy, it is imperative and practical to prioritize the identification of dietary or pharmacological interventions capable of upregulating DNAJB3 expression for therapeutic purposes. By advancing our understanding of DNAJB3's role in metabolic regulation, we pave the way for the development of innovative therapeutic strategies to alleviate the global burden of obesity and improve metabolic health. Collaboration between researchers, clinicians, and pharmaceutical industries is essential to translate these findings into effective clinical interventions and address the pressing public health challenge posed by obesity. Despite the significant insights gained, limitations, including the absence of mechanistic data on differential responses of WT and KO to insulin in stromal vascular cells are lacking and may provide insights into the underlying mechanisms by which DNAJB3 affects glucose homeostasis. Future studies should address these limitations and delve deeper into the nuanced mechanisms underlying complex DNAJB3 metabolic actions, including sex-specific regulations
Curing Cholera: Pathogens, Places and Poverty in South Asia
No full textIn this paper I will seek to provide a new understanding of endemicity of disease in India. Through a study of cholera research in the twentieth century I will argue that disease and its endemicity has to be understood in biological factors as well as within a wider social and economic context. I will discuss the medical efforts at locating the causality of cholera from the nineteenth century in Indian climate, water bodies and human anatomy to show that cholera is no more a biological phenomena than water is an ecological or environmental problem. Both are essentially political and economic questions
Hydrodesulfurization of crude oil over Co-Mo catalysts in a slurry reactor
No full textNoIn this paper, hydrodesulfurization
(HDS) of crude oil in the three-phase slurry reactor
over cobalt – molybdenum catalyst (CoMo / ɣ-
AL2O3) is studied. Effects of space velocity and
length of reactor on the conversion rate and
catalyst effectiveness for HDS process have been
investigated. Kinetics of the reaction rate for this
process is primarily and Arrhenius equation for
the rate constant is used. The results show that
the effectiveness factor for catalyst along the
length of reactor is decreased about 83%.
By increasing liquid velocity from 4 to 10 1/s,
the conversion of sulfur components is decreased
about 22% at the temperature of 523 K. At the
same temperature, by increasing liquid velocity
from 36 to 84 1/s conversion is reduced to 25%.
The results of the variation of the dimensionless
reaction rate against conversion show that with
increasing conversion, the reaction rate
decreases and the reaction is stopped when the
conversion is 100%
Overview of phytoplasma diseases in Asian countries
No full textPhytoplasmas have emerged as one of the most severe constraints in the production of several crops all around the Asian countries
during the past two decades. All-important crops that are cultivated mainly in South and East Asian countries are reported to be
infected with phytoplasmas with severe losses in yield and quality every year. Significant progress on the identification and
characterization of phytoplasmas, epidemiology, complete genome sequencing, and management of phytoplasma strains has
been achieved in the past two decades in Asia. A significant genetic diversity of phytoplasma strains associated with different
crops was also reported. So far, 17 ribosomal groups and 36 subgroups of phytoplasmas have been identified on about 250
plant species in Asia. The most widespread phytoplasma species are ‘Candidatus Phytoplasma asteris,’ ‘Candidatus
Phytoplasma australasia,’ ‘Candidatus Phytoplasma aurantifolia,’ ‘Candidatus Phytoplasma ziziphi,’ ‘Candidatus Phytoplasma
trifolii,’ ‘Candidatus Phytoplasma sacchari,’ and ‘Candidatus Phytoplasma cynodontis’ belonging to the RFLP groups 16SrI,
16SrII, 16SrV, 16SrVI, 16SrXI, and 16SrXIV. Sugarcane, bamboo species, sesame, vegetables, legumes, brassicas, palms,
stone fruits, seasonal ornamentals, and tree species are the major crops infected by phytoplasmas in Asia. Members of 14
‘Candidatus Phytoplasma’ species were also identified, and the great majority of them were only detected in the Asian
continent. Several leafhoppers, plant hoppers and psyllid and over 50 weed species were identified as vectors or potential
vectors and reservoirs, respectively, of phytoplasma strains in Asia. This chapter provides a comprehensive overview
concerning the diversity of phytoplasma strains associated with the major crops in Asian countries. This updated knowledge
and literature review about the geographical distribution of phytoplasma diseases in different countries of Asia would help
focusing on the most important diseases for developing management strategies in the respective countries and also alarm about
emerging phytoplasma diseases of quarantine concern
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