1,721,179 research outputs found
Targeting NGF system to fight neuropathic pain behavioral and immunohistochemical evidence in mice
Full text linkBackground and Aims: it has been demonstrated that the anti-NGF αD11 and the anti-TrkA MNAC13 counteract neuropathic pain in mice. The aim of this study was to evaluate the duration of the action of the two antibodies and the structural and morphological alterations induced in central and peripheral nervous system.
Methods: Chronic Constriction Injury (CCI) of the sciatic nerve was performed in C57BL/6J mice. Mice were administered with αD11 or MNAC13 (70 or 100 μg/mouse/day) from day 3 until day 10 post-CCI. Analgesic effects were tested through Dynamic Plantar Aesthesiometer from day 3 to day 90. Spinal cords and sciatic nerves were collected at D3, D11, D24 and D90 for immunohistochemistry.
Results: αD11 and MNAC13 induce significant dose- and time-dependent analgesic effects: the antiallodynic effect was still present at D90 following the highest doses of both antibodies. Immunohistochemical analysis show significant differences in inflammatory and myelination markers between treated and control animals, treated animals showing reduced glial and mast cells activation and a better nerve regeneration.
Conclusions: Data obtained prove that: i) the analgesic effect of the antibodies αD11 and MNAC13 are extremely long-lasting, being observable more than two months after the end of the treatment and ii) the antiNGF and antiTrkA antibodies reduce inflammation and facilitate the regenerative processes. Therefore, our results strongly support the importance of considering the NGF system in the development of novel therapies to modulate and control neuropathy
Ornamental stone finished product aesthetic inspection and characterization through a digital spectrophotometric approach
No full textMany manufactured good products present different market characteristics according to their pictorial aspects. Such aspects usually depends from many factors: in some cases they are related to the adopted production process, in other cases they are intrinsically linked to the handled material characteristics. Ornamental stone represent a typical example, where both the two previous mentioned factors have to be considered. Both the aspects, in fact, are of primarily importance to certify, in pictorial terms, the aesthetic attributes of slabs, tiles and, in general, of ornamental and/or dimensional stone based products. The study was mainly addressed to investigate the possibility to develop a methodology and a technique to measure the quality of the polished stone samples, evaluating at the same time, the effect of polishing on the final detected stone surface pictorial attributes. To reach such a goal a specially designed probe holder, together with computer generated spectrum analysis techniques, has been developed and measurements were made on various rock samples to quantify, independently from stone surface pictorial attributes, as color and texture, stone surface degree of polishing. The obtained results allowed to quantify the correlation existing between stone characteristics (constituting minerals, texture, structure) and surface status after different polishing actions
Contributi della psicoanalisi allo studio del gruppo
No full textCome la psicoanalisi teorica e clinica ha contribuito allo studio psicoanalitico dei grupp
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Venise l'art de la Serenissima- Dessins italiens des XVII et XVIIIe siècles, catalogo della mostra (Montpellier, Musée Fabre, 14.10.2006-14.1.2007)
No full textArte antica e contemporanea. Le collezioni della fondazione Cariverona e della fondazione Domus
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