1,721,066 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
REGULATION OF THE E3 LIGASE NEDD4
No full textNedd4 is the prototype member of the HECT E3 ubiquitin ligase family involved in signalling and cancer and is the subject of this work. In humans, there are nine members of this family that are implicated in a range of biological processes such as endocytosis, protein transport, viral budding, signalling, cellular growth and proliferation. Among them Nedd4 is involved in the intracellular trafficking of the epidermal growth factor receptor (EGFR), either directly or indirectly through its action on endocytic adaptors such as eps15 and epsins.
In this thesis we elucidated the mechanisms that regulate the activity of this E3 ligase. We addressed this issue with two approaches: i) protein interaction studies, crystallization analysis and mutagenesis approach were used to determine the intra-molecular interaction between ubiquitin and the HECT domain and between the C2 and the HECT domains and their biological relevance ii) mass spectrometry analysis was conducted on Nedd4 purified from cells in order to identify post-translational modifications induced by EGF stimulation.
We provided structural data on the ubiquitin-binding domain present in the HECT domain of the ligase and we demonstrated that it is critically required for the processivity of the enzyme. In addition, we found that the intra-molecular interaction between C2 and HECT domain maps very close to the ubiquitin-binding site in the HECT, inhibiting its activity. Finally, we identified an additional level of complexity exerted by post-translational modifications (ubiquitination and phosphorylation) in the context of the EGFR signalling cascade. The results described in this thesis suggest a model whereby in resting condition the ligase is inactive due to an intra-molecular interaction that limits the ubiquitin binding ability and the activity of the ligase; ubiquitination and phosphorylation induced by EGF stimulation may regulate the release of this auto-inhibition, leading to ligase activation and its membrane relocalization via the displaced C2 domain
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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