1,721,119 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Histological assessment of lipid deposition in tissues from genetically modified mice with deficiency or overexpression of apolipoprotein A-I
No full textThe reverse cholesterol transport is a multistep process whereby excess cholesterol is transported by HDL from the peripheral tissues to the liver for excretion. In this study, the impact of genetic manipulation of HDL/apoA-I levels on lipid deposition in liver and kidney was investigated.
Mice with extremely low plasma HDL levels, deficient for both murine apoA-I and apoE (DKO), were compared with mice characterized by elevated HDL, deficient for both apoA-I/apoE, but overexpressing human apoA-I (DKO/hA-I). Mice, both female and male, were fed a standard rodent diet until one year of age. Plasma lipids were quantified by enzymatic methods. Liver and kidney morphology was evaluated by light microscopy on frozen sections.
Plasma total cholesterol concentration in DKO mice was comparable with that of wild type mice and 3-fold lower than that observed in DKO/hA-I mice. Plasma HDL-C was almost absent in DKO mice and strongly elevated in DKO/hA-I mice. The H&E-stained sections did not reveal the presence of steatosis in liver parenchyma as well as of foam cells in renal glomeruli of both genotypes. The neutral lipid-specific staining with Oil Red O showed instead interesting differences. In the hepatic parenchyma, an increased accumulation of lipids around the centrilobular vein was observed only in DKO/hA-I mice. In addition, within the glomeruli of DKO/hA-I mice, lipid accumulation was significantly higher than in DKO, both in females and males.
Although DKO mice are almost completely devoid of HDL and prone to atherosclerosis development, they do not exhibit steatosis or other signs of abnormal lipid accumulation in the liver and do not develop glomerular lipidosis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Induction of anti-DNA antibodies in pre-autoimmune NZBxNZW F1 mice by immunization with a DNA-DNase I complex
No full textRecent studies suggest that anti-DNA antibodies may arise from the immune response to a complex of DNA and a DNA-binding protein. One of the protein targets frequently recognized by anti-DNA antibodies is the enzyme DNase I. To investigate the possible role of DNase I in the induction of anti-DNA antibodies, we immunized preautoimmune NZBxNZW F1 mice with a complex of DNA and DNase I emulsified in complete Freund's adjuvant. Control mice received DNA or DNase in adjuvant. IgG anti-dsDNA antibodies were induced in 50% of the mice immunized with DNA-DNase, in 25% of the mice immunized with DNase and in 6% of the mice immunized with DNA. However, immunized mice that produced anti-DNA antibodies did not develop renal disease. These data show that a DNA-binding protein like DNase may act as carrier in the immune response that leads to anti-DNA antibodies production in an autoimmune strain, but the induced anti-dsDNA antibodies have a low pathogenic potential
Interazione tra innervazione arteriosa e dislipidemia nella patogenesi dell'aterosclerosi = Cross-talk between arterial innervation and dyslipidemia in the pathogenesis of atherosclerosis
No full textÈ nota da tempo una relazione tra neurotrasmissione simpatica e ipercolesterolemia. La tonaca avventizia ospita ramificazioni del sistema simpatico, la cui ablazione può aumentare i livelli plasmatici di colesterolo e favorire l’aterosclerosi. A sua volta, l’ipercolesterolemia è in grado di inibire la neurotrasmissione simpatica. Nuovi approcci di trascrittomica e analisi ultrastrutturali dei vasi arteriosi potranno chiarire le basi molecolari dell’interazione tra sistema ner voso simpatico e metabolismo lipidico.A relationship between sympathetic neurotransmission and hypercholesterolemia has been established. The adventitia hosts sympathetic ner ve endings that, once ablated, cause hypercholesterolemia and promote atherosclerosis. On the other side, hypercholesterolemia can inhibit sympathetic neurotransmission. Novel transcriptomic approaches and ultrastructural analyses of the arterial vessel will be able to clarify the molecular bases of the cross-talk between sympathetic ner vous system and lipid metabolism
Chronic rupatadine treatment worsens atherosclerosis progression in apolipoprotein Eknockout mice fed Western-type diet
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