1,720,961 research outputs found
Morte e invalidità nel lavoro agricolo. 5 anni di infortuni in una provincia italiana: cronaca dell'intervento istituzionale.
No full textDetermination of morphine in the hair of heroin addicts by high performance liquid chromatography with fluorimetric detection
No full textA procedure has been presented for the quantitative determination of morphine contained in the hair of heroin addicts, by means of heat-acid hydrolysis, pre-column dansyl derivatization, straight phase liquid chromatography, and fluorescence detection. External standardization was used. Intra-assay and day-to-day variation coefficients were 5.6 and 7.8%, respectively (n = 10), when hair containing 1 ng/mg of morphine was assayed. Hair samples of 22 heroin addicts showed positive results in the range 0.08 to 15.7 ng/mg. No false positive results were found in 20 control subjects. A close correlation was shown between high performance liquid chromatography and radioimmunoassay results (y = 0.97x + 0.26)(r = 0.997, n = 15). Morphine hair content results significantly correlated with the grade of heroin use roughly estimated by means of serial determinations of morphine in urines during the last months before hair sampling
Calcitonin serum levels in heroin addicts: effects of methadone and clonidine detoxication treatments
No full textCalcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular 'C' cells of the thyroid which derive from the ultimobranchial body and, ultimately, from the neural crest. In man, the main role of this hormone is to protect the skeleton during periods of physiological stress, such as growth, pregnancy and lactation by reducing calcium loss [1]. Nevertheless, some recent data, such as the finding of immunoreactive CT-like material (iCT) in the central nervous system [2] and in the cerebrospinal fluid and the demonstration of its analgesic action in rabbits [4] and in man [5] indicate a relationship between CT and the neuroendocrine system. The purpose of the present study is to evaluate the levels of CT in a group of addicts to heroin both before and during detoxication treatment with methadone or a non-opioid drug like clonidine
Free and bound testosterone in male heroin addicts
No full textThe plasma levels of the active (free) fraction of testosterone (Te) and of Te Binding Globulin (TeBG) in a group of 42 heroin addicts with similar sexual difficulties were investigated for almost 2 years. Plasma levels of free Te were significantly low and TeBG were significantly high not only in the addicts with low total Te concentrations, but also in the addicts with normal values of total Te
Determination of morphine in biological fluids after immunoextraction and dansyl derivatisation.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Sviluppo di sistemi di sorveglianza epidemiologica in Sanità Pubblica.
No full textOBIETTIVI
Lo sviluppo delle tecniche di miniaturizzazione
dell’informazione ha reso in pratica illimitata la quantità di informazioni archiviabili in ogni settore mentre limitate sono le esperienze in atto nel settore
sanitario a livello di popolazione.
L’obiettivo del nostro studio è stato di costituire presso l’ASL 12 Veneziana della Regione Veneto
un Sistema Epidemiologico Integrato (SEI) che è
sostanzialmente un archivio permanente e continuamente aggiornato che integra le diverse fonti informative attraverso operazioni di record-linkage, utilizzando l’anagrafe sanitaria come matrice, e applicando algoritmi di definizione della casistica.
MATERIALI E METODI
I records utilizzati a questo scopo nel periodo
1998-2005 sono stati 16,606,850 per una popolazione annuale media di assistibili di circa 320,000 soggetti nel periodo considerato individuati attraverso
l’anagrafe sanitaria attraverso procedure di recordlinkage. Sono stati elaborati ed applicati algoritmi
patologia-specifici.
RIASSUNTO DEI RISULTATI
Sono state selezionate 50 patologie o aggregazioni di patologie seguendo la IX classificazione ICD
per le quali sono stati calcolati tassi grezzi e standardizzati di incidenza nei due sessi, nei diversi periodi di tempo, e nelle due diverse agglomerazioni urbane: Venezia,
e Mestre. Attraverso la georeferenziazione degli assistibili è stato possibile mappare le diverse patologie secondo i 17 quartieri/sestieri/aree in cui è suddivisa.
CONCLUSIONI
Questo primo insieme di risultati prodotti dal (SEI)
ha dimostrato la fattibilità di costruire, utilizzando i dati
sanitari correnti, sistemi di sorveglianza dell’intera popolazione degli assistiti. Il modello deve essere considerato, nelle sue scelte metodologiche, ancora sperimentale e richiederà ulteriori aggiornamenti e modifiche nelle successive revisioni. Il sistema consente la
creazione un sistema di sorveglianza di tipo longitudinale creando una coorte di assistibili utile sia per testare le ipotesi eziologiche che per analizzare la storia
naturale delle malattie. È attualmente in corso la sua
estensione all’ASL 18 di Rovigo (Regione Veneto)
Record of hospitalized acute intoxication cases: a proposed statistical-epidemiological card (Abstracts)
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