9 research outputs found
Title: Limits of Software Reuse Author(s): L. Holenderski
No full textAbstract: Software reuse is considered one of the main techniques to increase software productivity. We present two simple mathematical arguments that show some theoretical limits of reuse. It turns out that the increase of productivity due to internal reuse is at most linear, far from the needed exponential growth. Even worse, the linear increase can only be sustained during the first several years of applying internal reuse (later it saturates to a constant). With external reuse one can achieve exponential increase of productivity, at least in theory. Unfortunately, the price paid for the exponential growth is diminishing innovation. In fact, the innovation ratio due to external reuse diminishes exponentially fast to zero. Conclusions: Software reuse, either internal or external, cannot solve the software productivity problem, if employed as the only technique to increase software productivity. At least, not in a longer term. This is due to some fundamental theoretical limitations. We show that internal reuse saturates, leading to a constant growth that is far from the needed exponential growth. On the other hand, external reuse leads exponentially fast to diminishing innovation ratio
[S] Investigation of both thermal parameters and applications of closed-cell plastic thermal insulation foams with building energetic aspects
No full textNowadays, if one wants to renovate or build a building, the question of thermal insulation is an essential construction process. Polyurethane is a key thermal insulation material that belongs to plastic foams. It can be applied as a spread or board heat-insulating material. Its thermal insulation properties are superior compared to polystyrene, but still a bit neglected. In this article, we would like to perform thermal investigations executed on a new type of polymeric foam such as polyisocyanurate. We will present acceptably low thermal conductivity (~ 0.022 W m-1 k-1), raised specific heat capacity (~ 1400 J kg-1 K-1) and calorimetric (bomb and differential) measurement results completed with optical microscopic images. Moreover, scanning electron microscopic analysis and X-ray diffractometry will be also presented. The results will be used for cost calculations applied by buildings and will show justified reasons for its application based on structural measurements too. The results are extremely encouraging. © 2023, The Author(s).L
Animal welfare research – progress to date and future prospects
No full textpeer-reviewedRECORDABSTRACTARTICLE
Animal welfare research – progress to date and future prospects
OTHER
Author(s): L. Boyle 1 , M. Conneely 1 , E. Kennedy 1 , N. O’Connell 2 , K. O’Driscoll 1 , B. Earley 3 ,
Publication date (Electronic): 26 February 2022
Journal: Irish Journal of Agricultural and Food Research
Publisher: Compuscript
Keywords: Animal welfare, beef, dairy, pig, poultry, welfare assessment
Abstract
The welfare status of an animal is dependent on its ability to cope and exist in harmony with its environment, such that good physical and psychological health is maintained. Improving animal welfare is an increasingly important aspect of livestock production systems due, in a large extent, to increased consumer concerns about animal production practices. Animal welfare is an integrated part of quality assurance programmes for sustainable animal production, considering that welfare, health, management, economy, consumer acceptance and environmental impact are interdependent. The major welfare concerns in the livestock industry in recent years relate to the rearing and management of dairy calves, the welfare of the dairy cow, effect of husbandry management procedures on the welfare of beef cattle, rearing of sows in gestation and farrowing crates, and the broiler (meat) chicken sector. The paper will focus on scientific research underpinning these welfare concerns, with a particular focus on research conducted on the island of Ireland
Metabolic Analysis of Escherichia coli in response to Environmental and Genetic Alterations
No full text九州工業大学博士学位論文 学位記番号:情工博甲第145号 学位授与年月日:平成16年9月30日対象論文(1)：p.10-37収録論文「Applied Microbiology and Biotechnology」Vol.61, issue 2, pp.163-178,Springer Berlin / Heidelberg, 2003.4.掲載-[Title]：Global metabolic regulation analysis for Escherichia coli K12 based on protein expression by 2-dimensional electrophoresis and enzyme activity measurement[Author(s)]:L. Peng and K. Shimizu@@@対象論文(2)：p.38-55当該部分削除（著作権規定不明のため当該部分を削除）収録論文「Proceedings of Asian Pacific Biochemical Engineering Conference」8,Asian Pacific Biochemical Engineering Conference, 2003掲載-[Title]：Effect of ppc gene knockout on the metabolism of Escherichia coli in view of gene expressions, enzyme activities and intracellular metabolite concentrations[Author(s)]:Peng, Lifeng|Shimizu, Kazuyuki@@@対象論文(3)：p.80-99 当該部分削除（著作権規定不明のため当該部分を削除）収録論文 Vol.235, issue 1, pp.17-23 FEMS Microbiology Letters © 2008 Federation of European Microbiological Societies/Blackwell Publishing Ltd , 2004 掲載-[Title]：Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurements[Author(s)]:Peng, Lifeng|Arauzo-Bravo, Marcos J|Shimizu, KazuyukiThe final publication is available at www.springerlink.com平成16年
Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture
No full textIn a population-based study of older Swedish women, we investigated if clinical vertebral fracture was associated with lower health-related quality of life (HRQoL) and determined whether the association remained over time. Clinical vertebral fracture was associated with lower HRQoL and the effect persisted for up to 18.9 years. Introduction Vertebral fractures are often associated with back pain and reduced physical function, which might result in isolation and depression. As a result, women with vertebral fractures often have lower health-related quality of life (HRQoL), but during what time frame the decrease lingers is unclear. Therefore, the aim of this study was to investigate if clinical vertebral fracture and hip fracture were associated with lower HRQoL and to determine whether the associations remained over time. Methods Vertebral fracture assessments (VFA) were performed using dual-energy X-ray absorptiometry. Data regarding prior fractures, medications, medical history, and physical activity was collected using a questionnaire. Self-rated physical HRQoL was assessed using the 12-Item Short-Form Health Survey (SF-12). Women with clinical vertebral fractures were divided into tertiles according to time since fracture onset and their HRQoL was compared with non-fractured women. Results In a population-based cross-sectional study of 3028 women aged 77.8 ± 1.63 (mean ± SD), a total of 130 (4.3%) women reported at least one clinical vertebral fracture. Women with a clinical vertebral fracture, divided into tertiles (T1–T3) depending on time since the fracture occurred, had lower HRQoL (T1: 36.3 ± 10.8; T2: 41.0 ± 9.94; and T3:41.6 ± 11.4) than women without fracture (46.2 ± 10.6; p < 0.001). Using linear regression analysis, clinical vertebral fracture was associated with reduced physical HRQoL for up to 18.9 years, independently of covariates (age, height, weight, smoking, prior stroke, mental HRQoL, grip strength, and lumbar spine BMD). Conclusions Clinical vertebral fracture was associated with lower self-rated physical HRQoL, for up to 18.9 years after time of fracture. © 2019, The Author(s).L. Johansson and H. K. Svensson contributed equally to this work. Funding: This study was funded by the ALF/LUA grant from the Sahlgrenska University Hospital, the Swedish Research Council (VR), the Lundberg foundation, Agneta Prytz-Folk’s and Gösta Folke’s Foundation, and King Gustaf V’s and Queen Victoria’s Freemason Foundation.SUPER
Development of phenotypic indexes for the description of morphological injury in breast cancer cell mitochondria.
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Development of phenotypic indexes for the description of morphological injury in breast cancer cell mitochondria.
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Sub-category:
Tumor/Cell Biology
Category:
Tumor Biology
Meeting:
2009 ASCO Annual Meeting
Session Type and Session Title:
This abstract will not be presented at the 2009 ASCO Annual Meeting but has been published in conjunction with the meeting.
Abstract No:
e22055
Citation:
J Clin Oncol 27, 2009 (suppl; abstr e22055)
Author(s):
L. Putignani, S. Raffa, R. Pescosolido, F. Signore, D. Menichella, R. Boldrini, M. Torrisi, P. Grammatico; Bambino Gesù, Rome, Italy; S. Andrea Hospital, Rome, Italy; S. Camillo-Forlanini Hospital, Rome, Italy; Bambino Gesù Hospital, Rome, Italy; S. Andrea Hospital, University Sapienza, Rome, Italy
Abstract Disclosures
Faculty and Discussant Disclosures
Annual Meeting Planning Committee Disclosures
2009 Annual Meeting Proceedings Part I Errata
Abstract:
Background: Mitochondriopathy has been recently rekindled as new cancer theory. We report on structural damage of breast-infiltrating ductal carcinoma (IDC) mitochondria characterised by reduced expression levels of the oxidative phosphorylation system (OXPHOS). Methods: Mitochondria from HMC-1 (human mammary carcinoma) and HMEC (human mammary epithelial cell) cultures, traced by Mitotracker, were assayed for OXPHOS expression levels using cryo-immunoelectron microscopy (CIEM) quantitative labelling and fluorescence immunolabelling on unfractionated HMC-1 and HEMC cells. Convolution degeneration was established by transmission electron microscopy (TEM). Twenty different cell sections for both HMC-1 and HEMC cells, including 65 and 72 mitochondria, respectively, were randomly recorded and quantitatively analyzed for the percentage of area occupied by intact cristae to provide a grading of mitochondrial damage (cristae loss index). Results: Depressed expression levels were detected for all HMC-1 OXPHOS complexes by CIEM. Normalized labelling density (HEMC/HMC-1), expressed as colloidal gold particles/mitochondrial area (ρ) provided the following values: 1.77 for the NADH-ubiquinone oxidoreductase complex I NDUFS3; 1.86 for the succinate- dehydrogenase complex II SDH-B protein; 1.63 for the ubiquinol cytochrome c reductase complex III UQCRC2; 4.88 and 1.58 for the cytochrome-oxidase complex IV (CO) subunit I and IV, respectively; 2.70 for the ATP-synthase complex V F1β protein. Fluorescence immunolabelling confirmed CIEM quantitative data. MitoTracker's co-staining showed altered membrane potential and permeability. Injury grading was categorised assigning three levels of morphological damage: i) severe, ii) moderate, iii) slight, corresponding to 0 % (6.2 % and 1.4 % for HMC-1 and HMEC, respectively), 1-50 % (21.5 % and 2.8 % for HMC-1 and HMEC, respectively) and 51-75 % (44.6 % and 15.3 % for HMC-1 and HMEC, respectively) of area occupied by intact cristae (p<0.0001, χ2 Test). The entire HMC-1 mitochondrial damage resulted 3.7 times higher than that observed for HMEC cells (72.3HMC-1 %/19.5HMEC %). Conclusions: New phenotypic harm indexes for IDC cell mitochondria might provide new hallmarks in breast cancer cell biology
HWA Health Workforce Academy Virtual Health Workforce Academy Conference 2021. Beyond the research: Impact and translation to practice. Title Index
No full textPeer reviewed title and author list presented at the HWA Health Workforce Academy Virtual Health workforce Academy Conference 2021. Beyond the research: Impact and translation to practice."The effectiveness of trauma care systems at different stages of development in reducing mortality: a systematic review and meta-analysis protocol." Author/s - Alharbi R J; Lewis V; Shrestha S; Miller C - La Trobe University, School of Nursing & Midwifery"Limits to local-led innovation in rural health systems: exploring the ‘other side’ of responses to covid19 in Australia, Sweden, Canada and the United States of America." Author/s - Carson D.B - Central Queensland University, Australia; Petrie S - Carleton University, Canada.“What now?: Exploring the emergency healthcare response to domestic violence” A Grounded Theory Study within Regional Queensland Hospitals." Author/s - Dr. Shannon Dhollande & Professor Annabel Taylor - Central Queensland University, School of Nursing, Midwifery & Social Sciences, Associate Professor Silke Meyers - Monash University, Gender and Family Violence Prevention Centre, Dr. Mark Scot - Queensland Health, Metro North HHS, Caboolture Emergency Department"In or Out: Conducting cross-disciplinary research in three countries during COVID-19."Author/s - Kaphle, S & Preston, R - Central Queensland University, School of Health, Medical and Applied Sciences"From problem gambling to gambling problems: The assessment and measurement of gambling related harm." Author/s - Rawat V; Browne M - Central Queensland University, School of Health, Medical and Applied Sciences"The interpersonal and communication skills of care providers from the perspective of older patients’ with diabetes: Lithuanian case." Author/s - Bartkeviciute B & Prof. Lesauskaite V - Lithuanian University of Health Sciences, Lithuania (LUHS), Faculty of Nursing, Clinical Department of Geriatrics. Prof. Riklikiene O - Lithuanian University of Health Sciences, Faculty of Nursing, Nursing and care department"What are the experiences of Registered Nurses working in Residential Aged Care Facilities." Author/s - Channell P & Harvey C - Central Queensland University, School of Nursing, Midwifery & Social Sciences, De Bellis A - Flinders University, Adelaide."Understanding Aged Care Workforce arrangements - a research agenda." Author/s - Colley, L, Amarakoon, U & Khan, S - Central Queensland University, School of Business and Law"Stress of conscience among nurses caring of older people with delirium in hospitals." Author/s - Jokwiro, Y; Bish, M - Rural Department of Nursing and Midwifery, La Trobe Rural Health School, La Trobe University. Wilson E - Rural Department of Community Health, La Trobe Rural Health School, La Trobe University."Giving families a voice: it's only after you visit them that you discover things are going wrong." Author/s - Monson, A, Harvey, C & Baldwin, A - CQUniversity, School of Nursing, Midwifery and Social Sciences"Research into the continued use of restraint in Residential Aged Care Facilities." Author/s - Mulvogue J - Central Queensland University, School of Nursing, Midwifery and Social Sciences"Exploring the Impact of Employee Wellbeing on the Quality of Care Services in the Australian Aged Care Sector." Author/s -Perera A - Central Queensland University, School of Business and Law, Management and Commerce, Khan S.I - Central Queensland University, School of Business and Law, Business and Management, Amarakoon U - Central Queensland University, School of Business and Law, Human Resource Management"Healthcare educators assuming simulated patient roles in practice: A grounded theory study." Author/s - Rhodes J - Central Queensland University, School of Nursing, Midwifery and Social Sciences; Southern Institute of Technology, School of Nursing. Reid-Searl K - Central Queensland University, School of Nursing, Midwifery and Social Sciences. Baldwin A - Central Queensland University, School of Nursing, Midwifery and Social Sciences. Levett-Jones T - University of Technology Sydney, School of Nursing and Midwifery."Assessing student paramedics measurements of fatigue and quality of CPR on a simulated cardiac arrest case: A pilot study." Author/s - Weber A - Central Queensland University, School of Business and Law, Delport S; Delport A - Central Queensland University, School of Health, Medical and Applied Sciences"The Efficacy of Near Peer Teaching in paramedicine education: A literature Review." Author/s - Steve Whitfield - Griffith University School of Medicine (paramedicine)"Spiritual quality of life and well-being of paediatric patients: is a holistic care a declaration or reality?" Author/s - Juskauskiene E & Riklikiene O - Lithuanian University of Health Sciences, Faculty of Nursing, Department of Nursing and Care"Intercultural teaching, clinical practice and research experience in Australian Indigenous health. An Auto-ethnography." Author/s - Monica Lawrence - Flinders University of South Australia"The cultural approach towards advanced care planning in Japan: Policy recommendation." Author/s - Yumi Naito - Flinders University, College of Nursing and Health Sciences"Association of spiritual well-being with the healthy behavior in pregnancy." Author/s - Ruseckiene D - Lithuanian University of Health Sciences, Department of Obstetrics and Gynaecology, Riklikiene O - Lithuanian University of Health Sciences, Faculty of Nursing and Care."Applying Critical Discourse Analysis to Nursing Research." Author/s - Amy-Louise Byrne - Central Queensland University, School of Nursing, Midwifery and Social Science"Midwives and nurses use of early warning tools in hospital settings." Author/s - Ferguson B – Central Queensland University"Exploration of Experiences of Self-Management of a person living with Chronic Obstructive Pulmonary Disease: A Structured Literature Review." Author/s - McGoldrick C, Bradshaw J & Williamson M - Central Queensland University; Hendricks J"The influence of the move from fee-for-service payments to bundle payments on the role of the practice nurse." Author/s - Claire Verrall - Flinders University of South Australia College of Nursing and Midwifery"Planning for change: improving the use of sensory interventions in psychiatric units through knowledge translation models and frameworks." Author/s - L. Wright - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia P. Meredith - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, Australia S. Bennett - The Prince Charles Hospital, Metro North Mental Health Hospital and Health Services, Brisbane, Australia"Representation of acquired disabilities within disability employment research and policy: a literature review of models and their translation to service delivery practices." Author/s - Alan Zana - Central Queensland University, School of Nursing, Midwifery and Social Sciences</p
