374 research outputs found
Kitahata, S.
No full textPassport photo of man. Negative scan.In 1922, Kinso Ninomiya opened the Ninomiya Studio in Little Tokyo, Los Angeles. Due to Executive Order 9066 in 1942, the studio was forced to close but was reopened by Kinso and his son, Elwin Ichiro, in 1949. The studio operated in Little Tokyo until its final closing in 1986. The Ninomiya Studio Collection captures slices of Japanese American life in Los Angeles from the 1950s through the 1980s. The collection contains formal portraiture and candid photography in black and white and color as well as commercial photography for local businesses and reproductions of older photographs. The negatives come in a variety of sizes, including 8 x 10 inch negatives and panoramic negatives on Cirkut film. Each negative scanned has been selected out of multiple negatives and prints from a set. The title of the negative scan reflects the purchaser’s name
Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
No full textRyosuke Kitahata,1 Shinichiro Nakajima,1–4 Hiroyuki Uchida,1,3 Tetsu Hayashida,5 Maiko Takahashi,5 Shintaro Nio,1 Jinichi Hirano,1 Maki Nagaoka,1 Takefumi Suzuki,1 Hiromitsu Jinno,6 Yuko Kitagawa,5 Masaru Mimura1 1Psychopharmacology Research Program, Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; 2Multimodal Imaging Group – Research Imaging Centre, 3Geriatric Mental Health Division, Centre for Addiction and Mental Health, 4Department of Psychiatry, University of Toronto, Toronto, Canada; 5Department of Surgery, School of Medicine, Keio University, 6Department of Surgery, School of Medicine, Teikyo University, Tokyo, Japan Purpose: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy.Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions.Results: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions.Conclusion: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions. Keywords: breast cancer, chemotherapy, subjective cognitive function
Card from Kintaro Kitahara to Mitzi Naohara, December 1943
No full textAn invitation card to the wedding ceremony for Tayeko Kitahata and Sgt. Ray Kikumi Umade held at Third Christian Church Chapel 1 in the Poston camp in Arizona at 7:00 on Tuesday December 14, 1943. The caption reads: Tykies wedding announcement. An item from: Mitzi Naohara scrapbook (csudh_nao_0400), page 6.The George and Mitzi Naohara Papers consists of photo albums and scrapbooks compiled by George and Mitzi Naohara, and other documents pertaining to the Naohara and Masukawa family. Contained are photographs, correspondence, documents, and memorabilia depicting their experiences during World War II. George Nobuo Naohara is a Kibei Nisei, and his experiences include his farm labor in Idaho and Utah, incarceration in the Manzanar, Jerome, and Tule Lake camps, and the U.S. Army language school training and Korean War. He also engaged in Buddhist activities for his whole life and there are moving images depicting Gardena Buddhist Church activities after the war. Mitzi Masukawa Naohara was a preschool teacher at the Poston camp, Arizona, and also a member of a young Nisei women's club, "Sigma Debs.” Her collected materials depict her life as a teacher and social events in the Poston camp during the war
Theoretical study on the translation and rotation of an elliptic camphor particle
No full textThe spontaneous motion of an elliptic camphor particle floating on water is studied theoretically and experimentally. Considering a mathematical model for the motion of an elliptic camphor particle in a two-dimensional space, we first investigate the asymptotic solutions with numerical computation. We then introduce a small parameters into the definition of the particle shape, which represents an elliptic deformation from a circular shape and, by means of perturbation theory, we analytically calculate the travelling solution to within O(epsilon). The results show that short-axis-directed travelling solutions primarily bifurcate from stationary solutions and that long-axis-directed ones are secondary which means that elliptic camphor particles are easier to move in the short-axis direction. Furthermore, we show that rotating solutions bifurcate from stationary solutions and that the bifurcation point changes with 0(82), which suggests that elliptic camphor disks easily exhibit translational motion, rather than rotational, within the small deformation. Finally, our theoretical suggestions are confirmed by an experiment
Reaction-Induced Molecular Dancing and Boosted Diffusion of Enzymes
No full textA novel mechanism of reaction-induced active molecular motion, not involving any kind of self-propulsion, is proposed and analyzed. Because of the momentum exchange with the surrounding solvent, conformational transitions in mechano-chemical enzymes are accompanied by motions of their centers of mass. As we show, in combination with rotational diffusion, such repeated reciprocal motions generate an additional random walk - or molecular dancing - and hence boost translational diffusion of an enzyme. A systematic theory of this phenomenon is developed, using as an example a simple enzyme model of a rigid two-state dumbbell. To support the analysis, numerical simulations are performed. Our conclusion is that the phenomenon of molecular dancing could underlie the observations of reaction-induced diffusion enhancement in enzymes. Major experimental findings, such as the occurrence of leaps, the anti-chemotaxis, the linear dependence on the reaction turnover rate and on the rate of energy supply, become thus explained. Moreover, the dancing behavior is possible in other systems, natural and synthetic, too. In the future, interesting biotechnology applications may be developed using such effects
Hydrodynamic collective effects of active proteins in biological membranes
No full textLipid bilayers forming biological membranes are known to behave as viscous two-dimensional fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it was shown [A. S. Mikhailov and R. Kapral, Proc. Natl. Acad. Sci. USA 112, E3639 (2015)] that such active proteins should induce nonthermal fluctuating lipid flows leading to diffusion enhancement and chemotaxislike drift for passive inclusions in biomembranes. Here, a detailed analytical and numerical investigation of such effects is performed. The attention is focused on the situations when proteins are concentrated within lipid rafts. We demonstrate that passive particles tend to become attracted by active rafts and are accumulated inside them
Interaction of non-radially symmetric camphor particles
No full textIn this study, the interaction between two non-radially symmetric camphor particles is theoretically investigated and the equation describing the motion is derived as an ordinary differential system for the locations and the rotations. In particular, slightly modified non-radially symmetric cases from radial symmetry are extensively investigated and explicit motions are obtained. For example, it is theoretically shown that elliptically deformed camphor particles interact so as to be parallel with major axes. Such predicted motions are also checked by real experiments and numerical simulations. (C) 2017 Elsevier B.V. All rights reserved
Impact of the structures of macrocyclic Michael acceptors on covalent proteasome inhibition
No full textA systematic analysis of the structure–activity relationship of a series of syringolin analogues, which are irreversible covalent inhibitors of proteasomes.</p
Prolonged Culture of Mast Cells with High-Glucose Medium Enhances the FcεRI-Mediated Degranulation Response and Leukotriene C<sub>4</sub> Production
No full text<i>Background:</i> Mast cell-released chemical mediators such as histamine, leukotriene (LT) C<sub>4</sub> and prostaglandin (PG) D<sub>2</sub> lead to the onset of allergic disorders. ATP provided from glycolysis is essential for histamine release and LTC<sub>4</sub> secretion from mast cells upon Fc&#917;RI cross-linking, indicating that glucose is a primary environmental factor for mast cell activation. In this study, we investigated whether increases in concentrations of glucose in culture media affect the activation of bone marrow-derived mouse mast cells (BMMCs) upon Fc&#917;RI cross-linking. <i>Methods:</i> BMMCs were cultured in RPMI-1640 supplemented with varying concentrations (5.5, 11, 16.5, 22, 27.5 and 33 m<i>M</i>) of <i>D</i>-glucose for 3 h, or 1, 3 or 7 days. <i>D</i>-Mannitol was added to the medium containing 5.5 m<i>M</i><i>D</i>-glucose for osmotic control. After culturing, these cells were sensitized with anti-TNP IgE and then stimulated with TNP-BSA. <i>Results:</i> We found that long-term culture (7 days) of BMMCs with 33 m<i>M</i><i>D</i>-glucose increases the Fc&#917;RI-dependent release of β-hexosaminidase and LTC<sub>4</sub> without affecting surface expression levels of Fc&#917;RI, intracellular ATP levels or calcium signaling. Biochemical analyses demonstrated that Fc&#917;RI-dependent phosphorylation of cytosolic phospholipase A<sub>2</sub> (cPLA<sub>2</sub>) at the Ser505 residue was significantly increased by culturing with 33 m<i>M</i> glucose. <i>Conclusions:</i> Taken together, our data suggest that glucose can augment Fc&#917;RI-mediated mast cell activation, particularly the degranulation response and LTC<sub>4</sub> secretion after prolonged culture of mast cells with high-glucose medium. Moreover, it is suggested that increased phosphorylation of cPLA<sub>2</sub> at the Ser505 residue contributes to the enhancement of LTC<sub>4</sub> secretion.</jats:p
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