1,400 research outputs found
M. Kritou tou Patzē Tipoukeitos : sive Librorum LX Basilicorum summarium.
No full textVols. 4-5 have imprint: Città del Vaticano, Biblioteca Apostolica Vaticana.[v.1] Libros I-XII / graece et latine ediderunt C. Ferrini [et J. Mercati -- [2] Libros XIII-XXIII / ed. F. Doelger -- [3] Libros XXIV-XXXVIII / ed. S. Hoermann et E. Seidl -- [4] Libros XLIX-LX / ed. S. Hoermann et E. Seidl -- 5. Libros XXXIX-XLVIII / ed. S. Hoermann et E. Seidl.Mode of access: Internet
Writing on the Move: How Walking, Running, or Other Forms of Forward Movement Support the Writing Process
No full textA growing number of writers have been able to articulate how regular walking and running practices improve their writing practices. In this short presentation, Dr. Jackie Hoermann-Elliott introduces relevant theory on embodied learning's role in the writing, and reflects briefly on how and why she adapted the instructional language of this embodied exercise to support students who are not able to walk.Presentation will become available on August 17, 202
Bogue Donald J., Shryock Jr., Henry S. et Hoermann Siegfried A. — Subregional Migration in the United States 1935-1940. Volume I. Streams of Migration between Subregions. A Pilot Study of Migration Rows between Environments
No full textH. J. Bogue Donald J., Shryock Jr., Henry S. et Hoermann Siegfried A. — Subregional Migration in the United States 1935-1940. Volume I. Streams of Migration between Subregions. A Pilot Study of Migration Rows between Environments. In: Population, 13ᵉ année, n°2, 1958. p. 328
Ebner als Diagnostiker des linguistischen Verfalls
No full textL'analisi del filosofo austriaco del linguaggio e del decadimento linguistico della contemporaneità, con richiami a Wittgenstein e Karl Kraus
Variation in the Thyrotropic Activity of Human Chorionic Gonadotropin in Chinese Hamster Ovary Cells Arises from Differential Expression of the Human Thyrotropin Receptor and Microheterogeneity of the Hormone.
No full textThe role of hCG as a stimulator of the human thyroid has been a subject of controversy, because discrepant results have been obtained in different in vitro assays. In an attempt to explain the variation observed in the thyroid response to hCG, we investigated the ability of hCG and that of its isoforms and glycosylation variants to inhibit [125I]bovine (b) TSH binding and stimulate adenylate cyclase in two clones, JP09 and JP26, of Chinese hamster ovary cells stably transfected with the human TSH receptor (hTSHr). The two clones differed with respect to the number of hTSHr expressed per cell (34,000 in JP09 and 2,000 in JP26 cells). Both responded extremely well to bTSH; the cAMP response to 0.001 IU/L bTSH was distinguishable from basal values. Interestingly, JP09 cells were readily stimulated by hCG (20-100 mg/L; 0.52-2.6 x 10(-6) mol/L) to release cAMP, whereas JP26 cells showed little if any response. Also, cAMP stimulation produced by asialo-hCG was 12-fold in JP09 cells and only 4-fold in JP26 cells compared to 45- and 67-fold stimulations by bTSH, respectively. Stimulation by asialo-hCG was approximately 30% that of bTSH in JP09 cells, but less than 6% in JP26 cells. When assessing the thyrotropic activity of the microheterogeneous isoforms of hCG, more alkaline pI forms were found to be more active than those of a more acidic pI regardless of whether they were derived from normal or molar pregnancy urine. Further studies with hCG, asialo-hCG, asialoagalacto-hCG, and deglycosylated hCG revealed that removal of sialic acid caused a marked increase in both its affinity for hTSHr and its cAMP-releasing potency, whereas removal of further carbohydrate, although it slightly enhanced receptor binding, was detrimental to adenylate cyclase activation. In conclusion, differences in hTSHr expression may cause a variation in the cAMP response to hCG or its glycosylation variants, as does the microheterogeneity of the hormone itself. These mechanisms may be responsible at least in part for the divergent responses of different cell types to hCG and render interpretation of the physiological meaning of the data obtained in recombinant receptor systems difficult
Interaction of Human Chorionic Gonadotropin (hCG) and Asialo-hCG with Recombinant Human Thyrotropin Receptor.
No full texthCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma cell line (HTC) lacking endogenous TSHr with the full-length cDNA of the hTSHr. Unlike the wild type, the transfected cells, termed HTC-TSHr cells, were able to bind bovine TSH (bTSH) with high affinity and increase cAMP production in response to bTSH stimulation. Of the hCG forms, intact hCG displayed a weak activity to inhibit [125I] bTSH binding to HTC-TSHr cells, with 100 mg/L (2.6 x 10(-6) mol/L) producing maximally a 20% inhibition, whereas asialo-hCG achieved half-maximum binding inhibition at a concentration of 8 mg/L (2.3 x 10(-7) mol/L). The inhibitory constant (Ki) of asialo-hCG for recombinant hTSHr was calculated from saturation experiments in the presence of variable doses of bTSH and a fixed concentration of asialo-hCG to be approximately 8 x 10(-8) mol/L. The interaction of asialo-hCG with TSHr was further assessed by studies of the direct binding of the radioactively labeled hormone to both HTC and HTC-TSHr cells. [125I]Asialo-hCG binding to HTC-TSHr cells was 4.7%, compared to 1.5% in the wild-type cells lacking TSHr and was displaceable by bTSH (0.1-100 IU/L), indicating specific binding of the tracer to TSHr. Functionally, hCG (up to 100 mg/L; 2.6 x 10(-6) mol/L) proved unable to evoke any significant cAMP response over basal values in HTC-TSHr cells, as did asialo-hCG. Asialo-hCG, but not hCG, inhibited bTSH-stimulated adenylate cyclase activity in the cells in a dose-dependent manner. In conclusion, the present data show that intact hCG binds only weakly to HTC-TSHr cells and produces no significant cAMP stimulation, which is at variance with data obtained in FRTL-5 and Chinese hamster ovary-TSHr cells, but in good accord with previous findings in human thyroid membranes. Asialo-hCG, on the other hand, strongly binds to recombinant TSHr and inhibits the cAMP response to bTSH in HTC-TSHr cells, indicating that the desialylated hCG variant directly interacts with the receptor and truly is an antagonist of the hTSHr
Urban and Peri-urban Agriculture in Kyiv (Ukraine): "Crisis Induced Strategy" versus Recreational Resource
No full textFor the study 240 Kyiv households with urban and peri-urban agriculture (UPA) have been surveyed in 2005. Quotas were assigned to four different types of plots. A standardized questionnaire was developed to collect data on crop and animal production, inputs, sales of produce for income, importance of the plot for self-sufficiency, recreation and leisure time. A factor analysis is employed to reduce attitudinal data. Based on factor scores a cluster analysis is conducted to segment the respondents into more homogeneous groups and to show multiple purposes of UPA. Four clusters labeled as “Seekers of leisure activities”, “UPA-dependent growers”, “Recreation-oriented growers” and “Little engaged growers” are created. Multiple purposes of UPA are shown by profiling the clusters due to demographic, socioeconomic and other selected characteristics. The results show that depending on the type of plot the importance of UPA shifts from livelihood necessity to recreational resource or combines both.Urban and peri-urban agriculture, livelihood, Ukraine, Farm Management,
The Psychomotor Vigilance Test: Sources of State and Trait Variance
No full textWithin the context of pilot and air traffic controller selection tests the Psychomotor Vigilance Test (PVT, Dinges & Powell, 1985) was evaluated for its underlying sources of variance. The PVT is a simple visual reaction time task, which is well established as a measure of alertness during sustained operations. It provides scores for mean reaction times and number of lapses. While the PVT has proven sensitivity for temporary states of fatigue and other stressors in withinsubjects designs, validation studies are lacking to examine it for potential sources of trait variance, which could lead to confounding effects. This paper presents results from a validation study of the PVT with N = 247 air-traffic controller applicants. The PVT was administered in the morning before and in the evening after the selection tests. Lapses and mean reaction times show a different pattern of stability coefficients and inter-correlations with other tests. PVT-lapses appear to be more sensitive to state changes than mean reaction times. However, the change scores of the lapses seem to be confounded with individual personality traits. The PVT reaction time scores show significant correlations to selection tests of psychomotor skills, response orientation and vigilance. Implications for using the PVT as a potential selection test for pilots or air-traffic controllers are discussed
Type 2 allostatic load and thyroid function: supplementary S script
No full textS script accompanying the publication "The two faces of Janus: Why thyrotropin as a cardiovascular risk factor may be an ambiguous target."
This script is compatible with R 3.5 or newer. It uses original data of the NHANES study, which are available from https://www.cdc.gov/nchs/nhanes/
The following libraries, some of them coming with R, others being available from CRAN, are necessary for execution:
MASS
foreign
visreg
SPINA
Die Tochter Tehuan's oder Texas im vorigen Jahrhundert
No full textvon P. Alto S. Hörmann, O.S.B. Missionär in AmerikaTexas im vorigen Jahrhunder
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