72 research outputs found
Proyecto de edificio de bajos con bajos comerciales para D. Moisés Hadida y D. Salomón Serfaty.
No full textExpediente que recoge el proyecto de construcción de un inmueble, situado en el cruce de las calles General Aranda y 17 de Julio, de cuatro plantas y un ático, además de dotar a la baja de una entreplanta de tipo comercial. El expediente incluye memoria y ocho planos firmados por el arquitecto Alfonso de Sierra Ochoa. La memoria del arquitecto detalla la situación, descripción del proyecto, materiales de construcción, viabilidad, avances de presupuesto, condiciones de la construcción, y estilo de las fachadas. El proyecto es promovido pro Moise´s Hadida y Salomón Serfaty, tetuaníes judíos, promotores inmobiliarios de la ciudad, en la que han construido varios edificios de viviendas. El proyecto es diseñado por Alfonso de Sierra Ochoa, arquitecto teórico de la modernicación de la vivienda tetuaní, y responsable municipal de 1945 a 1949. Destaca por su labor urbanística, aunque diseña también proyectos privados de viviendas colectivas en el Ensanche. La edificación se sitúa en el Ensanche, en la calle General Aranda esquina con la calle 17 de Julio, correspondiente a la consolidación de la zona Sur-Este, que tuvo lugar durante la segunda mitad de los años cuarenta. Actualmente solo están construidos los bajos comerciales, no hay más plantas. El inmueble es un conjunto plurifamiliar, organizado con tres viviendas por planta. El diseño tipológico responde a una distribución racional de las cinco viviendas por planta, con agrupación de los espacios húmedos, la minimización de la distribución, y la diferenciación del uso de las habitaciones. El tamaño de las viviendascon tres dormitorios tiende hacia una normalización de las superficies y la proliferación de una clase media acomodada. En cierta medida, es de los primeros ejemplos de apertura hacia el estilo internacional, con una utilización racional de los materiales y huecos en la fachada
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A partially ordered semigroup of Boolean spaces.
No full textIn this thesis we are concerned with arithmetic in a certain partially ordered, commutative semigroup D. The first chapter investigates the class of countable Boolean algebras from which this semigroup arises. The elements of D correspond to the isomorphism classes of the Boolean algebras under consideration. In Chapter 2 we begin the study of the semigroup structure of D. D is axiomatically described by three groups of axioms. It is proved that these axioms are categorical. The ordering of D is used to investigate the multiplication. The set of T of torsion elements of D (elements with only finite many distinct powers), form a subsemigroup whose structure is studied. There is a natural torsion free quotient D/T whose structure is also investigated. In Chapter 3, the axioms are used to characterize elements s of T in terms of the arithmetic in the subsemigroup generated by the elements that are smaller than s. The characterization is used to determine elements of T that cover a single element. In the last part of Chapter 3, we obtain some sufficient, purely combinatorial conditions for an element to have infinite order
'The Face as a Battlefield' by Ygal Bursztyn
No full textThis text transposes, in the form of an article, the main themes tackled by the director Ygal Bursztyn in his book Face, Battlefield (Tel Aviv, Hakibbutz Hameuhad, 1990). Daniel Dayan thanks the author and the translator Sonia Hadida for their collaboration on this adaptation, reproduced with the kind permission of the review Hermes.</jats:p
Molecular heterogeneity and immunosuppressive microenvironment in Glioblastoma
No full textCopyright © 2020 DeCordova, Shastri, Tsolaki, Yasmin, Klein, Singh and Kishore. Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor prognosis, despite surgical resection combined with radio- and chemotherapy. The major clinical obstacles contributing to poor GBM prognosis are late diagnosis, diffuse infiltration, pseudo-palisading necrosis, microvascular proliferation, and resistance to conventional therapy. These challenges are further compounded by extensive inter- and intra-tumor heterogeneity and the dynamic plasticity of GBM cells. The complex heterogeneous nature of GBM cells is facilitated by the local inflammatory tumor microenvironment, which mostly induces tumor aggressiveness and drug resistance. An immunosuppressive tumor microenvironment of GBM provides multiple pathways for tumor immune evasion. Infiltrating immune cells, mostly tumor-associated macrophages, comprise much of the non-neoplastic population in GBM. Further understanding of the immune microenvironment of GBM is essential to make advances in the development of immunotherapeutics. Recently, whole-genome sequencing, epigenomics and transcriptional profiling have significantly helped improve the prognostic and therapeutic outcomes of GBM patients. Here, we discuss recent genomic advances, the role of innate and adaptive immune mechanisms, and the presence of an established immunosuppressive GBM microenvironment that suppresses and/or prevents the anti-tumor host response
Anti-Spike Antibodies Present in the Milk of SARS-CoV-2 Vaccinated Mothers Are Complement-Activating
No full textAlthough only 0.8–1% of SARS-CoV-2 infections are in the 0–9 age-group, pneumonia is still the leading cause of infant mortality globally. Antibodies specifically directed against SARS-CoV-2 spike protein (S) are produced during severe COVID-19 manifestations. Following vaccination, specific antibodies are also detected in the milk of breastfeeding mothers. Since antibody binding to viral antigens can trigger activation of the complement classical - pathway, we investigated antibody-dependent complement activation by anti-S immunoglobulins (Igs) present in breast milk following SARS-CoV-2 vaccination. This was in view of the fact that complement could play a fundamentally protective role against SARS-CoV-2 infection in newborns. Thus, 22 vaccinated, lactating healthcare and school workers were enrolled, and a sample of serum and milk was collected from each woman. We first tested for the presence of anti-S IgG and IgA in serum and milk of breastfeeding women by ELISA. We then measured the concentration of the first subcomponents of the three complement pathways (i.e., C1q, MBL, and C3) and the ability of anti-S Igs detected in milk to activate the complement in vitro. The current study demonstrated that vaccinated mothers have anti-S IgG in serum as well as in breast milk, which is capable of activating complement and may confer a protective benefit to breastfed newborns
ChemInform Abstract: Tris(2-(perfluorohexyl)ethyl)tin Hydride: A New Fluorous Reagent for Use in Traditional Organic Synthesis and Liquid Phase Combinatorial Synthesis.
No full textUpper Cenomanian – Lower Turonian (Cretaceous) calcareous algae from the Eastern Desert of Egypt: taxonomy and significance
No full textAn assemblage of calcareous algae (dasycladaleans and halimedaceans) is described from the Upper Cenomanian to Lower Turonian of the Galala and Maghra el Hadida formations (Wadi Araba, northern Eastern Desert, Egypt). The following taxa have been identified: Dissocladella sp., Neomeris mokragorensis RADOIČIĆ & SCHLAGINTWEIT 2007, Salpingoporella milovanovici RADOIČIĆ 1978, Trinocladus divnae RADOIČIĆ 2006, Trinocladus cf. radoicicae ELLIOTT 1968, and Halimeda cf. elliotti CONARD & RIOULT, 1977. Most of the species are recorded from the first time from Egypt. Three of the identified algae (T. divnae, S. milovanovici and H. elliotti) also occur in Cenomanian limestones of the Mirdita zone, Serbia, suggesting a trans-Tethyan distribution of these taxa during the early Late Cretaceous. The abundance and preservation of the algae suggest an autochthonous occurrence which can be used for the characterization of the depositional environment. The recorded calcareous as well as the sedimentologic and palaeontologic context of the Galala Formation support an open-lagoonal (non-restricted), warm-water setting. The Maghra el Hadida Formation was mainly deposited in a somewhat deeper, open shelf setting. Calcareous algae (Halimeda cf. elliotti CONARD & RIOULT) are restricted to one level in the uppermost Lower Turonian which indicates a brief return to shallow-water deposition after a significant deepening with maximum flooding during the early Early Turonian
ChemInform Abstract: Palladium-Catalyzed Heteroarylation of 1-(tert-Butyldimethylsilyl)-3- indolylzinc Chloride. Efficient Synthesis of 3-(2-Pyridyl)indoles.
No full textSíntese de tiol ésteres promovidos por óxido de cobre nanoparticulado, na presença de líquido iônico e irradiação de microondas
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2011No presente trabalho desenvolveu-se uma metodologia sintética para a obtenção de tiol ésteres a partir de cloretos de ácidos, dissulfetos de diorganoíla e óxido de cobre nanoparticulado. Além disso, utilizou-se líquidos iônico como solvente e irradiação de micro-ondas. Nesta metodologia, não está envolvido o uso de bases/agentes redutores, caracterizando o processo ambientalmente adequado. Além disso, utilizou-se dissulfetos de dioganoíla como material de partida, o que torna a metodologia atraente, pois evitou-se o uso de tióis que apresentam odores desagradáveis. Adicionalmente, sintetizou-se tiocarbonatos contendo interessantes funcionalidades. Quando se utilizou cloroformiato de benzila e cloroformiato de 9- fluorenilmetila os correspondentes tiocarbonatos foram obtidos em rendimentos satisfatórios. Ao término da síntese dos tiol ésteres, foi realizada a reciclagem do líquido iônico, onde observou-se que ele pode ser reutilizado até 3 vezes com perda mínima no rendimento da reação. Também foi realizado o trabalho de recuperação do catalisador CuO nano e o estudo de seu desempenho em nesta metodologia, com o passar dos ciclos. A recuperação do catalisador foi eficiente, uma vez que se mostrou efetivo até a 2ª recuperação. Os tiol ésteres sintetizados por esta metodologia foram obtidos com rendimentos satisfatórios que variaram de 15 até 96%.In the present work, we developed a new synthetic methodology for the synthesis of thiol esters , starting from acid chloride, diorganyl disulfides and copper nanoparticle. In addition, we used ionic liquid as solvent and microwave irradiation. In this metodology, there is not involving the use of bases/reducing agents, characterizing the process environmentally sound. In addition, we used the diorganyl disulfides as starting material, which makes our approach attractive because it avoided the use of thiols that have unpleasant odors. Additionally, summed up thiocarbonates containing interesting features. When we used benzyl chloroformate and 9-fluorenylmethyl chloroformate the corresponding thiocarbonates were obtained in satisfactory yields. At the end of the synthesis of thiol esters, was performed the recover of the ionic liquid , where we can observe that it can be reused up to 3 times with minimal loss in yield of the reaction. Was also carried out work on recycling the catalyst CuO nano and performance study for our methodology, over the cycles. The recovery of the catalyst was efficient, since it was effective until the 2nd cycle. The thiol esters synthesized by this method were obtained with satisfactory yields ranging from 15 to 96 %
A MODIFIED APPROACH TO THE LATTICE BOLTZMANN MODEL (LBM) BASED ANALYSIS OF RADIATIVE HEAT TRANSPORT
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