782 research outputs found
First record of Wayanad shieldtail Melanophidium wynaudense (Beddome, 1863) from the Central Western Ghats, India
No full textS. R. Ganesh, P. Gowri Shankar, R. Sreeka
Inhibition of Proliferation of HeLa Cells by Pulsed Electric Field Treated Mentha piperita (Mint) Extract
No full textIn this research, the effectiveness of Mentha piperita (M. piperita) leaf extract against HeLa, a human cervical cancer cell line was investigated. We assessed the phytochemicals present in this extract by phytochemical screening tests and analysed the free radical scavenging activity and anticarcinogenic activity using without Pulsed Electric Field (PEF). The methanolic M. piperita extract was prepared by the Soxhlet extraction method, and was treated by PEF using 50 unipolar pulses, 10 kV/cm, 100 mu s and the effect of PEF on the antioxidant and anticarcinogenic activities of M. piperita extract was investigated and compared to Soxhlet extraction (70 degrees C for 8 h). The preliminary phytochemical analysis indicated the presence of phenols, tannins, flavonoids, alkaloids, steroids, reducing sugars and the absence of saponins, anthocyanins, catechins, terpenoids, carotenoids, and anthraquinones. The free radical scavenging activity of both PEF treated and untreated extract was determined by 2,2-Diphenyl-1-Picrylhydrazyl assay. Compared to untreated extract, 7.36% greater antioxidant activity was obtained from PEF treatment. The anticarcinogenic activity of both extracts were determined by MTT proliferation assay against Hela cells. The results indicated a viability of 34.77% for the PEF treated M. piperita extract (compared to 41.2% for the Soxhlet extract and 100% for the control). This indicates that the PEF-treated M. piperita extract showed higher antioxidant activity and anticarcinogenic activity than the other extracts. Hence, the application of PEF may be appropriate to achieve antioxidant rich extract and maximal cell death could be achieved with PEF treatment thereby, reducing the concentration of extract required for treating cancer
Taxonomic revision of the king cobra Ophiophagus hannah (Cantor, 1836) species complex (Reptilia: Serpentes: Elapidae), with the description of two new species
No full textThe taxonomy of king cobras (Ophiophagus) was reevaluated using qualitative, mensural and meristic characters, based on 148 entire and five skeletal specimens, and supported by a recent molecular phylogenetic analysis. We provide nomenclatural synopses of both the genus and species-series nomina. We restrict the concept of Ophiophagus hannah s. str. to populations from eastern Pakistan, northern and eastern India, the Andaman Islands, Indo-Burma and Indo-China, south to central Thailand. The nomen Ophiophagus bungarus (Schlegel, 1837) comb. nov. is revived for the populations inhabiting the Sunda Shelf area, including the Malay Peninsula, the Greater Sunda Islands and parts of the southern Philippines. We describe two new species, Ophiophagus kaalinga Gowri Shankar, Das & Ganesh sp. nov. endemic to the Western Ghats of south-western India and Ophiophagus salvatana Gowri Shankar, Das & Wüster sp. nov., inhabiting the island of Luzon in northern Philippines. For the purpose of nomenclatural stability, we designate a neotype for Hamadryas hannah Cantor, 1836. A dichotomous identification key to the four species recognized here is provided
Clinical trials in dentistry in India: Analysis from trial registry
No full textIntroduction: Evidence-based practice requires clinical trials to be performed. In India, if any clinical trial has to be performed, it has to be registered with clinical trial registry of India. Studies have shown that the report of clinical trials is poor in dentistry. Hence, the present study has been conducted to assess the type and trends of clinical trials being undertaken in dentistry in India over a span of 6 years.
Methodology: All the clinical trials which were registered with the Central Trial Registry of India (CTRI) (www.ctri.nic.in) from January 1, 2007 to March 3, 2014 were evaluated using the keyword “dental.” Following information were collected for each of the clinical trials obtained from the search; number of centres (single center/multicentric), type of the institution undertaking the research (government/private/combined), study (observational/interventional), study design (randomized/single blinded/double-blinded), type of health condition, type of participants (healthy/patients), sponsors (academia/commercial), phase of clinical trial (Phase 1/2/3/4), publication details (published/not published), whether it was a postgraduate thesis or not and prospective or retrospective registration of clinical trials, methodological quality (method of randomization, allocation concealment). Descriptive statistics was used for analysis of various categories. Trend analysis was done to assess the changes over a period of time.
Results: The search yielded a total of 84 trials of which majority of them were single centered. Considering the study design more than half of the registered clinical trials were double-blinded (47/84 [56%]). With regard to the place of conducting a trial, most of the trials were planned to be performed in private hospitals (56/84 [66.7%]). Most (79/84, 94.1%) of the clinical trials were interventional while only 5/84 (5.9%) were observational. Majority (65/84, 77.4%) of the registered clinical trials were recruiting patients while the rest were being done in healthy participants. From 2011, some of the postgraduate thesis trials had also been registered (2011-8; 2012-8; 2013-13; 2014-6). Inadequacy in reporting the method of randomization and allocation concealment was observed in 37/67 (55.2%) and 31/67 (46.2%) clinical trials respectively. A considerable number of postgraduate theses was also registered with CTRI in dentistry and majority of the clinical trials despite being completed are not yet published.
Conclusion: The number of clinical trials in dentistry are low in India, and more focus should be placed by dental investigators regarding the reporting standards. Furthermore, researchers and trial sponsors should aim at publication of the research findings so that it is made publically available for use. A clear-cut need exists for an increase in both the quantity and quality of clinical trials in dentistry
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study
No full textAims/hypothesisCirculating succinate and 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) were recently shown to promote brown adipocyte thermogenesis and protect against metabolic disorders in rodents. This study aimed to evaluate the associations between plasma levels of these metabolites and adiposity and metabolic profile in humans.MethodsFasting plasma succinate and 12,13-diHOME levels were quantified using ultra HPLC-tandem MS in 2248 individuals (50% female, mean age 41.3 ± 5.9 years, mean BMI 26.1 ± 4.6 kg/m2) in addition to fasting plasma biochemistry. Total and regional adiposity were assessed with dual-energy x-ray absorptiometry. An age- and sex-adjusted linear regression model was used to determine the associations between succinate and 12,13-diHOME levels and body composition and metabolic profile. Two-sample Mendelian randomisation was used to assess the associations between genetically determined BMI and metabolic traits with circulating plasma succinate and 12,13-diHOME.ResultsA one-SD higher plasma succinate and 12,13-diHOME concentration was associated with a 0.15 SD (95% CI 0.28, 0.03) and 0.08 SD (0.15, 0.01) lower total fat mass respectively. Additionally, a one-SD higher plasma 12,13-diHOME level was associated with a 0.09 SD (0.16, 0.02) lower fasting plasma insulin and 0.10 SD (0.17, 0.04) lower plasma triacylglycerol. In Mendelian randomisation analyses, genetically determined higher BMI, fasting hyperinsulinaemia and elevated lipid levels were not associated with changes in either plasma succinate or plasma 12,13-diHOME concentrations. No indications of bias due to directional pleiotropy were detected in the Mendelian randomisation analyses.Conclusions/interpretationOur findings tentatively suggest that plasma succinate and 12,13-diHOME may play a role in the regulation of energy metabolism and brown adipose tissue activation in humans. Further studies encompassing direct assessment of brown adipose tissue activity and dietary supplementation are necessary to investigate the potential beneficial effects of these metabolites on systemic metabolism
Isolation and Characterization of Pediocin PA-1 Producing Lactic Acid Bacteria
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Evaluation of effectiveness of intraoral delivery tip on single step impressions using monophase and two-phase impression materials: An in vivo study
No full textBackground and Rationale: The precise fit of prosthesis depends on the impression materials and the technique used. Addition silicone impression materials being the user-friendly material are used in monophase and two-phase techniques. Considering the paucity of data on the effectiveness of intraoral delivery tip (IODT) on void, tear and bubble formation using monophase impression technique in stock tray and two-phase impression technique in custom tray the present study was initiated.
Materials and Methods: A total of 50 patients requiring single complete veneer crowns were enrolled. Monophase and two-phase impressions with and without IODT were made. Evaluation of the impression were made for tears, voids, and bubbles and alpha, beta, delta scores were given.
Results: A significant reduction in the total number of voids was observed with two-phase technique either with or without IODT. No significant differences were observed in the proportion of overall evaluation into alpha, beta and delta between monophase and two-phase with and without IODT. No significant association was seen in the overall evaluation between the two groups (monophase and two-phase) as compared using Chi-square test for independency and a trend in association between overall evaluation as tested using Chi-square for linear trend analysis.
Conclusion: Two-phase impression technique with the use of IODT produced decreased number of voids
Carbohydrate Profile of Basmati and Non-Basmati Rice Varieties
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
A Review on Performance of Toll Plaza by using Queuing Theory
No full textOne of the key problems in the study of any stream of traffic system is the analysis of delay. Delay is a more delicate concept. It may be well defined as the difference between the actual travel time on a given section and some ideal travel time of that section. This raises the question as what is the ideal travel time. In practice, the ideal travel time chosen will depend on the situation. There are two particular travel times that seem best suited as benchmarks for assessment with the actual performance of the system. These are the travel times under free flow conditions and travel time at capacity. Most recent research has found that for highway systems, there is reasonably little difference between these two speeds. The analysis of delay normally focuses on the delay when demand exceeds its capacity. Such delay is known as queuing delay, and may be studied by means of queuing theory. This theory involves the analysis which is known as a queuing system, which is composed of a server, a stream of customers who demand service, and a queue or line of customers waiting to be served. A. N. V. Ravindra | Mr. S. Siva Gowri Prasad "A Review on Performance of Toll Plaza by using Queuing Theory" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd28068.pd
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