3,131 research outputs found
Free jet millimeter wave spectroscopy of oxazolidinone compounds.
No full text2-Oxazolidinone (systematic name 1,3-oxazolidin-2-one) is a five-member heterocyclic ring exhibiting potential medicinal roperties. It is the pharmacophore of a class of antimicrobial agents which have a unique structure and good activity gainst Gram-positive pathogenic bacteria (e.g. linezolid, the first in clinical use 2-oxazolidinone antibiotic). Often the functionality of drugs is related to their conformational flexibility and ability to form non covalent interactions with ts urroundings. In order to understand how substitution affect these properties, a series of oxazolidone compounds has been studied by means of millimeter wave free jet Stark modulated absorption spectroscopy [1] and quantum mechanical
calculations. The achieved data will be presented. [1] C. Calabrese, A. Maris, L. Evangelisti, L.B. Favero, S. Melandri and W. Caminati, J. Phys. Chem. A, 117, 13712 (2013)
Una chiesa sopra i colli di S. Pietro
No full textIllustra beni storico - artistici, poco noti, della chiesa di San Pietro di Fonte (presso Bassano del Grappa): Opere di Jacopo Bassano, Giambattista Canal
Artificial pancreas: A review of fundamentals and inpatient and outpatient studies
No full textThe artificial pancreas (AP) is a device for automated modulation of insulin infusion that aims to maintain blood glucose in a nearly normal range. The core of the AP is the control algorithm, which is in charge of computing an effective insulin dose on the basis of continuous glucose monitoring readings. In the last 6 years, AP prototypes based on subcutaneous glucose sensing and subcutaneous insulin delivery have been extensively studied in clinical trials first on hospitalized patients and, more recently, in an outpatient setting. In this chapter we review the state of the art of the field, starting with a description of the various AP system components. In particular, we focus on the control techniques employed in the AP and on the principles on which they are based. We then move to AP testing: The preclinical stage (mostly done in silico), the inpatient clinical studies, and finally the outpatient studies. We also discuss the technological requirements for an ambulatory AP
Research methodology for ethnostatistics in organization studies: towards a historical ethnostatistics
No full textPurpose: While quantification and performance measurement have proliferated widely in academia and the business world, management and organization scholars increasingly agree on the need for a more in-depth focus on the complex dynamics embedded in the construction, use and effects of quantitative measures (pertaining to the thread of research called ethnostatistics). This paper develops a pluralistic method for conducting ethnostatistical research in organizational settings. Whilst presenting practical techniques for conducting research in live settings, it also discusses how historical approaches which focus on source criticism and contextual reconstruction could overcome the limitations of ethnostatistics.
Design/methodology/approach: The methodological approach of this paper encompasses an in-depth discussion of the ethnostatistical method, its underlying assumptions and its methodological limitations. Based on this analysis, the authors propose a pluralistic method (model) for conducting ethnostatistical research in organizational settings based on the integration of 1) research practices employed by one of the authors conducting ethnostatistical research in a large multinational organization and 2) best practices from ethnographic and historical research.
Findings: This paper suggests how historical approaches can successfully join ethnostatistical enquiries in an attempt to overcome some limitations in existing conventional methods. The developed framework explores four levels of analysis (ethnography, statistics at work, rhetoric of statistics and history of statistics) and suggests practical approaches for each level that can contribute to strengthening the research output and overcoming limitations when using ethnostatistics.
Originality/value: This paper contributes to the ethnostatistical field by discussing the intersection between history and ethnography and the ways for their complementary use in organizational and management research on quantification processes. As such it offers unique insights and hands-on experience from conducting ethnostatistical enquiries in live organizational settings
Venezia dopo Venezia: Economia e demografia urbana nel Novecento.
No full textSubject of this paper is the relationship between the urban population, the inhabitants (many or few, young or old, male or female) who live in the Venice island, and the economic functions that the city has taken or has been assigned during the twentieth century. The author in fact believes that the answer to some crucial questions concerning the city of today, asking how Venice could become what it is today, should be researched exactely in the interplay between projects of displacement and resettlement of the population, related to an idea of the historical city that becomes unchangeable in its own structure in the mid century
PROTON DONOR/ACCEPTOR PROPENSITIES OF AMMONIA: ROTATIONAL STUDIES OF ITS MOLECULAR COMPLEXES WITH ORGANIC MOLECULES
No full textB.~M.~Giuliano, M.~C.~Castrovilli, A.~Maris, S.~Melandri, W.~Caminati and E.~A.~Cohen, \textit{Chem.Phys.Lett.B.~M.~Giuliano, S.~Melandri, A.~Maris, L.~B.~Favero and W.~Caminati, \textit{Angew.Chem.Int.Ed.Author Institution: Dipartimento di Chimica "G. Ciamician" dell'Universita, Via Selmi 2, I-40126 Bologna, ItalyWe studied the rotational spectra of the adducts of ammonia with several organic molecules, namely \textit{tert}-butanol,, 2008, 463, 330} glycidol,, 2009, 48, 1102} ethyl alcohol, anisol and 1,4-difluorobenzene. The adducts with glycidol and ethanol have been observed for both conformers of the substrate molecule. Based on the rotational and N quadrupole coupling constants of the various complexes, we found a considerably different behaviour of ammonia, with respect to water, in its proton donor/acceptor double role. In the interaction with the three alcohol molecules, NH acts as a proton acceptor and the OH groups as a proton donor. However, in the case of glycidol-NH, a secundary N-HO interaction occurrs between ammonia and the ether oxygen. This interaction generates a sizable \textit{V} barrier to the internal rotation of the NH moiety, while NH undergoes a free rotation in \textit{tert}-butanol-NH and in ethanol-NH. As to the anisole-NH and 1,4-difluorobenzene-NH complexes, the NH group explicits its double proton donor/acceptor role, although through two weak (C-HN and N-H) H-bonds. There is, however, an important difference between the two complexes, because in the first one NH lies out of the aromatic plane, while in the second one it is in the plane of the aromatic ring
Importance of the hydrogen bond in tautomeric equilibria and in molecular complex formation. Rotational spectroscopy in supersonic expansions
No full textThe importance of weak interactions, especially inter and intramolecular hydrogen bonds, is recognized in all areas of chemistry and biology and the understanding of their role is essential to explain and model many phenomena.
In our studies the detailed nature of such interactions is revealed by high resolution spectral data on isolated molecules and molecular complexes observed in free jet expansions. The interpretation of these data is assisted by high level quantum chemical calculations and other models to help justify and rationalize the results.
We report microwave spectroscopy studies on molecules isolated in supersonic expansions: 4-hydroxypyrimidine,1 methylsalycilate and erythritol, and show the importance of hydrogen bond formation on the shape of the tautomeric and conformational potential energy surface and on the geometry of the stable structures.
The study of small molecular hydrogen bonded complexes such as dimers or trimers is also very interesting and can be considered a starting point towards the understanding of bulk properties.
Weak and strong intermolecular hydrogen bonds (C-H...F, C-H...N, O-H...N) can be observed in the structures of the trimer of difluoromethane,2 pyridine- CHF3 or pyridine-water. These molecular complexes are stabilized by more than one hydrogen bond but they are also highly dynamical.
1. Sanchez, R.; Giuliano, B.M.; Favero ,L.B.; Caminati, W., J. Am. Chem. Soc., 2007, 129, 6287-6290
2..Blanco, S.; Melandri, S.; Ottaviani, P.; Caminati, W.; J. Am. Chem. Soc.; 2007; 129(9), 2700 – 270
Allergic Rhinitis and Asthma: Relationship with Transverse Maxillary Contraction and Transverse Expansion Stability in Children
No full textBackground: Allergic rhinitis is a frequent cause of nasal obstruction in the pediatric population. The effect of prolonged mouth breathing on craniofacial growth continues to be a controversial topic in the orthodontic literature. This study investigates both the role of allergic rhinitis/asthma in the etiology of posterior crossbite and ogival palate and the influence of allergic rhinitis/asthma on the long-term stability produced by transverse expansion treatment. Methods: A retrospective analysis of the clinical records of 319 subjects between 5 and 12 years, presenting for an orthodontic evaluation was performed. The sample was divided into study and control groups depending on the presence/absence of posterior crossbite and/or ogival palate. Data regarding the subjects’ breathing patterns and allergic respiratory diseases were collected. The relapse rate of transverse expansion treatment was evaluated. Results: An association (p = 0.05) was found between posterior crossbite/ogival palate and the presence of allergies. Multivariate analyses uncovered that both allergic rhinitis and younger ages were associated with posterior crossbite/ogival palate (p = 0.029890; p = 0.000283, respectively). No association was found between allergies and/or asthma and relapse following orthodontic treatment. Conclusions: Although data analysis suggests that allergies can induce transverse maxillary contraction in children, their presence did not seem to affect the outcome of orthodontic expansion treatment
Due storie della statistica in Italia
No full textDiscussione sulla storia della statistica in Italia a partire dalla pubblicazione dei volumi monografici di S. Patriarca, Numbers and Nationhood: Writing Statistics in 19th Century Italy, Cambridge University Press 1996, e di D. Marucco, L'amministrazione della statistica nell'Italia unita, Laterza 1996
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