386 research outputs found
A Cryogenic 1024-Channel Mixed-Signal ASIC for SiPM Readout in 110 nm CMOS for the GRAIN Detector at DUNE
No full textM.T. Beonio Brocchieri Fumagalli, Durando di S. Porziano. Elementi filosofici della terza redazione del « Commento alle Sentenze »
No full textPattin Adriaan. M.T. Beonio Brocchieri Fumagalli, Durando di S. Porziano. Elementi filosofici della terza redazione del « Commento alle Sentenze ». In: Revue Philosophique de Louvain. Quatrième série, tome 70, n°5, 1972. p. 159
Accuracy assessment of analysis of a free-fall gravimeter data
No full textThe measurement of the local acceleration due to gravity is based on the orbit reconstruction of the free fall in vacuo of a test mass [1]. In the set-up of the Istituto di Metrologia “G. Colonnetti” the test mass, which embeds a retroreflector, is tossed up and its ascent and descent are tracked and timed by a laser interferometer and a rubidium clock. The data actually supplied by the instrument is time versus fixed fringe number and the gravity value is obtained by fitting time-height pairs to a parabolic motion model. In order to overcome the limits of this procedure, to assess data processing, and to achieve full information about the test mass orbit, traveling interference fringes have been digitized by means of a fast Analog to Digital (AD) converter with 8-bit resolution and the entire interferometer signal is recorded for subsequent analysis [2]. The present article deals with the reconstruction of the test mass orbit and error propagation through gravity calculation. Owing to timing errors and noise correlation, the uncertainty resulting from conventional error propagation through least squares calculation is smaller than the actual one. To avoid underestimation, noise characterization and modeling was carried out and asymptotic formulae expressing the measurement uncertainty were obtained and verified against experimental data
The Nootropic Drug Α-Glyceryl-Phosphoryl-Ethanolamine Exerts Neuroprotective Effects in Human Hippocampal Cells
No full textBrain aging involves changes in the lipid membrane composition that lead to a decrease in membrane excitability and neurotransmitter release. These membrane modifications have been identified as contributing factors in age-related memory decline. In this sense, precursors of phospholipids (PLs) can restore the physiological composition of cellular membranes and produce valuable therapeutic effects in brain aging. Among promising drugs, alpha-glycerylphosphorylethanolamine (GPE) has demonstrated protective effects in amyloid-injured astrocytes and in an aging model of human neural stem cells. However, the compound properties on mature neuronal cells remain unexplored. Herein, GPE was tested in human hippocampal neurons, which are involved in learning and memory, and characterized by a functional cholinergic transmission, thus representing a valuable cellular model to explore the beneficial properties of GPE. GPE induced the release of the main membrane phospholipids and of the acetylcholine neurotransmitter. Moreover, the compound reduced lipid peroxidation and enhanced membrane fluidity of human brain cells. GPE counteracted the DNA damage and viability decrease observed in in vitro aged neurons. Among GPE treatment effects, the autophagy was found positively upregulated. Overall, these results confirm the beneficial effects of GPE treatment and suggest the compound as a promising drug to preserve hippocampal neurons and virtually memory performances
Parsonage–Turner syndrome following coronavirus disease 2019 immunization with ChAdOx1-S vaccine: a case report and review of the literature
No full textBackground: Parsonage–Turner syndrome is an acute peripheral neuropathy that affects the upper brachial plexus region. Previously published reports demonstrate that the condition can be triggered by surgery, infection, autoimmune diseases, strenuous exercise, trauma, radiation, and vaccination. Parsonage–Turner syndrome has already been reported in three other patients who were vaccinated against coronavirus disease 2019. Case presentation: We report the case of a 51-year-old Caucasian man without comorbidities who received the first dose of the ChAdOx1-S recombinant vaccine (Vaxzevria, AstraZeneca, Oxford, UK) against coronavirus disease 2019 and was diagnosed with Parsonage–Turner syndrome. A few days after getting vaccinated, the patient reported a progressive increase in pain in the region of vaccine administration. One month later, the shoulder pain was followed by symptoms of hypoesthesia and muscle weakness on abduction and elevation of the left upper limb. Neurological examination revealed an atrophy of the proximal muscles of the left upper limb, accompanied by paresis of the left deltoid, biceps brachii, triceps brachii, and infraspinatus muscles. Electroneuromyography carried out 3 months after the onset of symptoms showed signs consistent with brachial plexus neuritis. The adverse reaction has been properly reported to the Italian Pharmacovigilance System (Italian Medicines Agency—Agenzia Italiana del Farmaco. Conclusion: The increased awareness of such association is essential for early identification and diagnosis and, thus, better clinical outcomes
Multi-body numerical simulation of the distribution drive system in an internal combustion engine
No full textV clanku je predstaven vyvoj metodiky pro vypocet dynamiky mechanismu motoroveho rozvodu. Vyuzity jsou techniky simulaci
vicehmotovych soustav; pouzit byl software AVL/Tycon. Objektem vyzkumu byl vliv pracovnfho rezimu motoru na dynamiku
retezoveho rozvodu s jednim (SOHC) a dvema (DOHC) vackovymi hndeli v hiave motoru. Analyza obsahuje dukaz, ze retezovy
prevod zavadi (di'ky kinematickemu zaberu) vysokou frekvenci s velmi malou amplitudou v porovnani s harmonickymi frekvencemi
od externi sil. Metodika umozhuje urdt zati'zeni vstupni'ho a pomocnych hridelu, zatizeni na strukturu motoru indukovane pres
operne a napmaci kladky. Diky tomu se predstavena metodika stava vyznamnym nastrojem pro predvidani zatizeni; a navic
umoznuje i detailni vypocet trecich ztrat v jednotlivych castech retezoveho rozvodu.The purpose of the present work is the development of a methodology to study the dynamic behavior of the drive distribution
system, based on the techniques of multi-body numerical simulation using AVL/Tycon code. Chain drive systems with both
single cam shaft (SOHC) and double cam shaft (DOHC) are studied to investigate how the dynamic behavior varies with the
engine working rate. The analysis includes evidence that the chain transmissions introduce a high frequency due to kinematic
engagement (polygon effect), with a very low amplitude with regard to the harmonics of external forces. The methodology permits
the evaluation of the loads on the drive shaft, on the distribution shafts, and loads acting on the engine structure through the
supports and constraint points. It represents an important forecasting tool; moreover, it also permits the detailed calculation of
the friction lost in the interaction between the chain components
Infodemiological data concerning silicosis in the USA in the period 2004–2010 correlating with real-world statistical data
No full textAbstractThis article reports data concerning silicosis-related web-activities using Google Trends (GT) capturing the Internet behavior in the USA for the period 2004–2010. GT-generated data were then compared with the most recent available epidemiological data of silicosis mortality obtained from the Centers for Disease Control and Prevention for the same study period. Statistically significant correlations with epidemiological data of silicosis (r=0.805, p-value <0.05) and other related web searches were found. The temporal trend well correlated with the epidemiological data, as well as the geospatial distribution of the web-activities with the geographic epidemiology of silicosis
Vaccine-preventable diseases : From paediatric to adult targets
No full textThe morbidity and mortality related to many communicable infectious diseases have significantly decreased in Western countries largely because of the use of antibiotics, and the implementation of well-planned vaccination strategies and national immunisation schedules specifically aimed at infants and children. However, although immunisation has proved to be highly effective for public health, more effort is needed to improve the currently sub-optimal rates of vaccination against various diseases among adults who may be at risk because of their age, medical condition or occupation. The vaccines currently licenced in Western countries are safe, immunogenic and effective against many infectious diseases and their complications, but the availability of newer vaccines or vaccines with new indications, the evolving ecology and epidemiology of many infections, population ageing, and other demographic changes (i.e. the increasing prevalence of chronic comorbidities and immunodeficiencies, mass migration, new working relationships, and widespread international tourism) require changes in the approach to immunisation. There is now a need for appropriate preventive measures for adults and the elderly aimed at protecting people at risk by using every possible catch-up opportunity and recommending specific age-related schedules on the basis of local epidemiology
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